[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458798-105":59,"doc-detail-458798-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","association-between-anaemia-and-osteoporosis-a-systematic-review-and-meta-analysis","Association between anaemia and osteoporosis - a systematic review and meta-analysis","","Osteoporosis significantly contributes to global morbidity, while emerging evidence indicates anaemia may affect osteoporosis risk. This systematic review and meta-analysis examines the association between anaemia and osteoporosis, using searches across PubMed, Scopus, EBSCO, and ScienceDirect. Eighteen studies with 861,540 participants show anaemia significantly increases osteoporosis risk (OR 1.62; 95% CI 1.33–1.98; p \u003C 0.001) with high heterogeneity, and multivariate results remain significant (OR 2.01; 95% CI 1.26–3.21; p = 0.004).",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/association-between-anaemia-and-osteoporosis-a-systematic-review-and-meta-analysis/458798/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/association-between-anaemia-and-osteoporosis-a-systematic-review-and-meta-analysis/458798.png","ImageObject",300,407,{"name":92,"@type":93},"Fans","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the purpose of the systematic review and meta-analysis?","Question",{"text":113,"@type":114},"To investigate whether anaemia is associated with osteoporosis risk, based on observational studies and pooled effect estimates.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which databases and time range were searched?",{"text":118,"@type":114},"PubMed, Scopus, ScienceDirect, and EBSCO were searched comprehensively up to 9 May 2025, without language or publication-year restrictions.",{"name":120,"@type":111,"acceptedAnswer":121},"How many studies and participants were included, and what was the main finding?",{"text":122,"@type":114},"Eighteen studies involving 861,540 participants were analyzed, and anaemia significantly increased osteoporosis risk in univariate and multivariate analyses.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},458798,1790819013,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},5909892330395,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","AnnAls of Medicine  \n2026, Vol. 58, no. 1, 2610878  \n[https://doi.org/10.1080/07853890.2025.2610878](https://doi.org/10.1080/07853890.2025.2610878)  \nRESEARCH ARTICLE     \nAssociation between anaemia and osteoporosis: a systematic review and meta-analysis  \nAlveron Andreas Teara , Florencia Anastasia Tesnoa, Haneira Shofiadeitaa, Gading Marcell Bungaa, Hamidah Nur Taqiyaa, Najwa Audrey Sandithaa, Ayesha Humayra Fayyazaa, Samantha Kerenhapukh Tiurlina Tambunana, Gisela Kayla Wangsaa, Qanita Reezqi Fatimaha, Istiqomah Istiqomahb, Widya Wibawantyb and Leonardo Lubisb   \nafaculty of Medicine, Universitas Padjadjaran, Bandung, indonesia; bdepartment of Biomedical sciences, faculty of Medicine, Universitas Padjadjaran, Bandung, indonesia  \nABSTRACT  \nBackground: Osteoporosis significantly impacts global morbidity. Recent evidence suggests anaemia may contribute to osteoporosis risk. This systematic review and meta-analysis investigates this association.  \nMethods: PubMed, Scopus, EBSCO, and ScienceDirect were searched for papers. Studies with definition of anaemia and assessing osteoporosis outcomes were included. Meta-analysis utilized random-effects models (DerSimonian-Laird method), and study quality was assessed via Newcastle-Ottawa Scale (NOS). Analyses were performed using R Studio.  \nResult: Eighteen studies (861,540 participants) were analyzed. Anaemia significantly increased osteoporosis risk in univariate analysis (OR 1.62; 95% CI 1.33–1.98; p \u003C 0.001), despite high heterogeneity (I2 = 92.7%). The results remain significant in studies that reported multivariate analysis (OR 2.01; 95% CI 1.26–3.21; p = 0.004). Sensitivity analyses confirmed the robustness of our result.  \nConclusion: Anaemia significantly associated with osteoporosis, emphasizing the need for targeted screening in anaemic individuals. Further studies should consider incorporating anaemia into osteoporosis and fracture prediction tools.  \nIntroduction  \nARTICLE HISTORY  \nReceived 25 August 2025 Accepted 24 December 2025  \nKEYWORDS  \nAnaemia; haemoglobin; osteoporosis; risk factor  \nOsteoporosis is a systemic skeletal disorder characterized by reduced bone mineral density (BMD) and altered bone microarchitecture, increasing bone fragility and fracture risk [1–3] . Globally, over 200 million individuals are affected, with approximately 9 million osteoporotic fractures occurring annually [4] . Osteoporotic fractures significantly reduce quality of life and increase morbidity and mortality, especially among older adults [1] .  \nHaemoglobin (Hb), the primary protein transporting oxygen to tissues, is suggested to influence bone health. Anaemia is one of the most common blood disorders worldwide, contributing to significant morbidity and mortality. Globally, it affects nearly a quarter of the population, approximately 1.9 billion people [5] . It is highly prevalent in older adults, which are populations with higher osteoporosis risk and increased fracture susceptibility [6] . Chronic anaemia can induce hypoxaemia, increasing osteoclastic activity and disrupting bone remodelling, thereby accelerating bone mass loss [7] .  \nRecent studies support this association; increased Hb levels correlate with reduced osteoporosis risk, whereas anaemia significantly increases osteoporosis incidence [7] . Low Hb levels are linked to reduced BMD and nearly double the risk of osteoporotic fractures. Thus, haemoglobin status may be a valuable  \nCONTACT leonardo lubis  [leonardo@unpad.ac.id](leonardo@unpad.ac.id)  department of Biomedical sciences, Universitas Padjadjaran, Bandung, West Java, 40161, indonesia  \n supplemental data for this article can be accessed online at [https://doi.org/10.1080/07853890.2025.2610878](https://doi.org/10.1080/07853890.2025.2610878) .  \n© 2026 The Author(s) . Published by informa UK limited, trading as Taylor & francis Group  \nThis is an open Access article distributed under the terms of the creative commons Attribution license ([http://creativecommo","cbCaifU5LZ7XAwf8","https://ap.wps.com/l/cbCaifU5LZ7XAwf8","pdf",1137424,"English","# Abstract\n# Background\n# Methods\n## Search strategy\n## Study selection\n## Data extraction and quality assessment\n# Result\n# Conclusion\n# Introduction\n# Article history\n# Keywords","[{\"question\":\"What is the purpose of the systematic review and meta-analysis?\",\"answer\":\"To investigate whether anaemia is associated with osteoporosis risk, based on observational studies and pooled effect estimates.\"},{\"question\":\"Which databases and time range were searched?\",\"answer\":\"PubMed, Scopus, ScienceDirect, and EBSCO were searched comprehensively up to 9 May 2025, without language or publication-year restrictions.\"},{\"question\":\"How many studies and participants were included, and what was the main finding?\",\"answer\":\"Eighteen studies involving 861,540 participants were analyzed, and anaemia significantly increased osteoporosis risk in univariate and multivariate analyses.\"}]","Association between anaemia and osteoporosis - a systematic review and meta-analysis | PDF",1790754471,28]