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Design: Prospective study in children aged 5–9 receiving pulpectomy, with longitudinal follow-up until primary molar exfoliation and successor premolar eruption. Outcomes included enamel developmental defects, ectopic eruption, and crown rotation, analyzed using logistic regression. Results and conclusion summarize the observed alteration frequencies and lack of significant associations with evaluated variables.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/assessment-of-alterations-in-permanent-premolars-after-endodontic-treatment-of-predecessor-primary-molars-prospective-study/468128/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/assessment-of-alterations-in-permanent-premolars-after-endodontic-treatment-of-predecessor-primary-molars-prospective-study/468128.png","ImageObject",300,407,{"name":42,"@type":43},"Liam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What clinical alterations were assessed in permanent premolars after pulpectomy of primary molars?","Question",{"text":63,"@type":64},"The study assessed developmental defects of enamel, ectopic eruption, and crown rotation in the successor permanent premolars.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the pulpectomy performed in the primary molars?",{"text":68,"@type":64},"Root canals were instrumented and obturated with a zinc oxide-eugenol paste after pulpectomy.",{"name":70,"@type":61,"acceptedAnswer":71},"Did the endodontic treatment variables show an association with later premolar alterations?",{"text":72,"@type":64},"No statistically significant associations were found between the assessed alterations and demographic or treatment-related variables, including pulp status, interradicular lesion, root resorption, or root overfilling (p > 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Alterations in Permanent Premolars After Endodontic Treatment of Predecessor Primary Molars: A Prospective Study  \nRafaela Lourdes de Sousa | Elisa Varela de Oliveira | Josiane Pezzini Soares  | Nashalie Alencar  | Jéssica Barasuol  | Pablo Silveira Santos  | Mariane Cardoso | Michele Bolan  \nDepartment of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil Correspondence: Michele Bolan ([michelebolan@hotmail.com](michelebolan@hotmail.com))  \nReceived: 10 January 2025 | Revised: 5 June 2025 | Accepted: 21 July 2025  \nFunding: This study was supported in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.  \nKeywords: deciduous tooth | developmental defects of enamel | ectopic tooth eruption | endodontics  \nABSTRACT  \nBackground: The relationship between primary teeth and their successors involves complex interactions that may influence the development of permanent teeth.  \nAim: To evaluate alterations in permanent premolars after endodontic treatment of their primary molar predecessors.  \nDesign: A prospective study was conducted with children initially aged 5 to 9 years, who were submitted to pulpectomy of a primary molar. The protocol involved instrumentation of root canals and obturation with a zinc oxide-eugenol paste. Follow-up examinations were performed until exfoliation of the primary molars and full eruption of the successor premolar. Permanent premolars were assessed for developmental defects of enamel, ectopic eruption, and crown rotation. Logistic regression was used to explore variables associated with these outcomes.  \nResults: Forty-seven children were followed up for approximately 6 years. Among the successor permanent premolars, 21.3% presented crown rotation, 10.6% ectopic eruption, 6.4% enamel hypomineralization, and 2.1% enamel hypoplasia. No statistically significant association was observed between the assessed alterations and demographic or treatment-related variables, including pulp status, interradicular lesion, root resorption, or root overfilling (p >0.05) .  \nConclusion: Eruptive alterations were the most frequent findings. No association was identified between variables related to the endodontic treatment of primary molars and subsequent clinical alterations in permanent premolars.  \n1 | Introduction  \nThe occurrence of early childhood caries and traumatic dental injuries is the main cause leading to pulpal damage, which affects a significant number of children in the primary dentition phase [1] . These conditions often lead to repercussions for the permanent successor tooth germ due to its close proximity to the affected primary tooth [2] . Such consequences typically arise from pulpal infection [2] or the direct impact of trauma [3, 4] .  \nWhen apical periodontitis in primary teeth extends to the developing permanent germ, it may interfere with odontogenesis, resulting in a range of sequelae, including enamel hypomineralization or hypoplasia, arrested development of the permanent tooth, formation of dentigerous cysts, germ expulsion resembling bone sequestration in osteomyelitis, and alterations in the follicular structure [1, 5, 6] . These changes may affect the reduced enamel epithelium, the gubernacular canal, and ultimately disrupt the eruption process [7] .  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Author(s). International Journal of Paediatric Dentistry published by BSPD, IAPD and John Wiley & Sons Ltd.  \nInternational Journal of Paediatric Dentistry, 2026; 36:33–39 33  \n[https://doi.org/10.1111/ipd.70024](https://doi.org/10.1111/ipd.70024)  \nSummary  \n• Why this paper is important to pediatric dentists  \n○ Provides long-term clinical evidence on de","cbCaikE2fIsoC8r1","https://ap.wps.com/l/cbCaikE2fIsoC8r1","pdf",379655,"English","# Abstract\n## Background\n## Aim\n## Design\n## Results\n## Conclusion","[{\"question\":\"What clinical alterations were assessed in permanent premolars after pulpectomy of primary molars?\",\"answer\":\"The study assessed developmental defects of enamel, ectopic eruption, and crown rotation in the successor permanent premolars.\"},{\"question\":\"How was the pulpectomy performed in the primary molars?\",\"answer\":\"Root canals were instrumented and obturated with a zinc oxide-eugenol paste after pulpectomy.\"},{\"question\":\"Did the endodontic treatment variables show an association with later premolar alterations?\",\"answer\":\"No statistically significant associations were found between the assessed alterations and demographic or treatment-related variables, including pulp status, interradicular lesion, root resorption, or root overfilling (p \\u003e 0.05).\"}]","Assessment of Alterations in Permanent Premolars After Endodontic Treatment of Predecessor Primary Molars - Prospective Study | PDF",1790773788,18]