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This study examined whether hyperglycemia combined with hyperinsulinemia promotes breast cancer cell progression by profiling gene dysregulation in MCF7 cells using microarray expression analysis. The treatment produced a distinct 45-gene signature, and public GEO data showed 15 genes upregulated in diabetic breast tumor tissues. Key genes SLC26A11, ALDH1A3, MED20, PABPC4 and SCP2 appeared among top upregulated candidates across datasets. Results suggest monitoring diabetes-associated metabolic alterations could support improved breast cancer outcomes, with further studies needed to define the highlighted genes across glycemic statuses.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/assessing-the-link-between-diabetic-metabolic-dysregulation-and-breast-cancer-progression-article/380231/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/assessing-the-link-between-diabetic-metabolic-dysregulation-and-breast-cancer-progression-article/380231.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main goal of the study described in the abstract?","Question",{"text":113,"@type":114},"To identify the molecular mechanism by which hyperglycemia combined with hyperinsulinemia may influence breast cancer cell progression.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were gene dysregulation changes assessed?",{"text":118,"@type":114},"Gene dysregulation was analyzed using a microarray gene expression assay after exposing MCF7 breast cancer cells to hyperglycemia or to the combined condition.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the study find about gene expression in diabetic breast tumor tissues?",{"text":122,"@type":114},"In silico analysis using the GEO dataset (GSE150586) showed differential upregulation of 15 genes in breast tumor tissues from diabetic patients, with several genes overlapping between datasets.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},380231,1790682255,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Article  \nAssessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression  \nSamrein B. M. Ahmed 1,2,3,*, Nada Radwan 1, Sara Amer 1, Narjes Saheb Sharif-Askari 1,2, Amena Mahdami 1, Kamel A. Samara 2, Rabih Halwani 1,2 and Herbert F. Jelinek 4  \nCitation: Ahmed, S.B.M.; Radwan, N.; Amer, S.; Saheb Sharif-Askari, N.; Mahdami, A.; Samara, K.A.; Halwani, R.; Jelinek, H.F. Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression. Int. J. Mol. Sci. 2023, 24, 11816. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms241411816  \nAcademic Editor: Jean-François Tanti  \nReceived: 5 July 2023  \nRevised: 19 July 2023  \nAccepted: 20 July 2023  \nPublished: 23 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates; [md_saleema@outlook.com](md_saleema@outlook.com) (S.A.); [rhalwani@sharjah.ac.ae](rhalwani@sharjah.ac.ae) (R.H.)  \n2 College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates  \n3 College of Health, Wellbeing and Life Sciences, Department of Biosciences and Chemistry, Sheffield Hallam University, Sheffield S1 1WB, UK  \n4 Department of Biomedical Engineering and Health Engineering Innovation Center, Khalifa University, Abu Dhabi 127788, United Arab Emirates  \n* Correspondence: [samrein.ahmed@shu.ac.uk](samrein.ahmed@shu.ac.uk)  \nAbstract: Diabetes mellitus is a burdensome disease that affects various cellular functions through altered glucose metabolism. Several reports have linked diabetes to cancer development; however, the exact molecular mechanism of how diabetes-related traits contribute to cancer progression isnot fully understood. The current study aimed to explore the molecular mechanism underlying the potential effect of hyperglycemia combined with hyperinsulinemia on the progression of breast cancer cells. To this end, gene dysregulation induced by the exposure of MCF7 breast cancer cells to hyperglycemia (HG), or a combination of hyperglycemia and hyperinsulinemia (HGI), was analyzed using a microarray gene expression assay. Hyperglycemia combined with hyperinsulinemia induced differential expression of 45 genes (greater than or equal to two-fold), which were not shared by other treatments. On the other hand, in silico analysis performed using a publicly available dataset (GEO: GSE150586) revealed differential upregulation of 15 genes in the breast tumor tissues of diabetic patients with breast cancer when compared with breast cancer patients with no diabetes. SLC26A11, ALDH1A3, MED20, PABPC4 and SCP2 were among the top upregulated genes in both microarray data and the in silico analysis. In conclusion, hyperglycemia combined with hyperinsulinemia caused a likely unique signature that contributes to acquiring more carcinogenic traits. Indeed, these findings might potentially add emphasis on how monitoring diabetes-related metabolic alteration as an adjunct to diabetes therapy is important in improving breast cancer outcomes. However, further detailed studies are required to decipher the role of the highlighted genes, in this study, in the pathogenesis of breast cancer in patients with a different glycemic index.  \nKeywords: breast cancer; diabetes; hyperglycemia; hyperinsulinemia; gene dysregulation  \n1. Introduction  \nAberrant glucose metabolism has been linked to poor breast cancer outcomes [1,2] . It is well established that diabetic/hyperglycemic metastatic cancer patients have a decreased overall survival compared to a nondiabetic/normoglycemic control group [3] . Previous reports have ","cbCaicEWxgnvhvIO","https://ap.wps.com/l/cbCaicEWxgnvhvIO","pdf",2337148,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"What is the main goal of the study described in the abstract?\",\"answer\":\"To identify the molecular mechanism by which hyperglycemia combined with hyperinsulinemia may influence breast cancer cell progression.\"},{\"question\":\"How were gene dysregulation changes assessed?\",\"answer\":\"Gene dysregulation was analyzed using a microarray gene expression assay after exposing MCF7 breast cancer cells to hyperglycemia or to the combined condition.\"},{\"question\":\"What did the study find about gene expression in diabetic breast tumor tissues?\",\"answer\":\"In silico analysis using the GEO dataset (GSE150586) showed differential upregulation of 15 genes in breast tumor tissues from diabetic patients, with several genes overlapping between datasets.\"}]","Assessing the Link between Diabetic Metabolic Dysregulation and Breast Cancer Progression - Article | PDF",1790239314,48]