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Procedure time, intraoperative events, postoperative pain/fever, pathology, and 17-month follow-up outcomes were assessed. No recurrence, metastasis, or esophageal inlet stenosis was observed. 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Postoperatively, postoperative pain occurred in 5 patients and fever in 1 patient.",{"name":74,"@type":61,"acceptedAnswer":75},"What did follow-up show regarding recurrence or progression?",{"text":76,"@type":64},"The mean follow-up was 17 months, and no recurrence, metastasis, or esophageal inlet stenosis was observed in any patient.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},353081,1790480061,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,114,119,124,127,131],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},7,40,"healthcare",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},8,"Research & Report",30,"research-report",{"id":120,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":122,"slug":123},9,"Religion & Spirituality",20,"religion-spirituality",{"id":122,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":122,"slug":126},"World Cup","world-cup",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":128,"slug":130},10,"Lifestyle","lifestyle",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":133,"show_sort_weight":101,"slug":134},19,"General","general",{"code":4,"msg":86,"data":136},{"doc_id":83,"user_id":137,"nickname":42,"user_avatar":138,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":144,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":12,"update_tm":148,"read_time":122},2336477974920,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","TYPE Original Research PUBLISHED 29 May 2026  \nDOI 10.3389/fonc.2026.1738370  \nOPEN ACCESS  \nEDITED BY  \nMohamed El-Sherbiny,  \nAlmaarefa University, Saudi Arabia  \nREVIEWED BY  \nMohammad El-Nablaway, Mansoura University, Egypt Priyanka Rawat,  \nChildren ’s Hospital of Philadelphia Research Institute, United States  \n*CORRESPONDENCE  \nTingsheng Ling  \n [chinalts2024@163.com](chinalts2024@163.com)  \n†These authors share first authorship  \nRECEIVED 03 November 2025  \nREVISED 13 April 2026  \nACCEPTED 20 April 2026  \nPUBLISHED 29 May 2026  \nCITATION  \nLiu C, Zhang Q, Wang Y and Ling T (2026) Assessing the effectiveness of endoscopic submucosal dissection for hypopharyngeal lesions-a comprehensive evaluation.  \nFront. Oncol. 16:1738370 .  \ndoi: 10.3389/fonc.2026.1738370  \nCOPYRIGHT  \n© 2026 Liu, Zhang, Wang and Ling. This isan open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nAssessing the effectiveness of endoscopic submucosal dissection for hypopharyngeal lesions-a comprehensive evaluation  \nChangen Liu 1†, Qiang Zhang 2†, Yaohui Wang 3 and Tingsheng Ling 2*  \n1 Department of Gastroenterology and Hepatology, Central Hospital, Tianjin University /Tianjin Third Central Hospital, Tianjin Institute of Geriatrics, Tianjin Third Central Hospital Branch, Tianjin, China, 2 Digestive Endoscopy Center, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine), Nanjing, China, 3 Pathology Department, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine),  \nNanjing, China  \nBackground: Superficial hypopharyngeal carcinoma typically presents with no obvious clinical manifestations but poses significant management challenges due to its unique anatomical location and potential aggressiveness.  \nObjective: To evaluate the clinical efficacy and safety of endoscopic submucosal dissection (ESD) in the treatment of superficial hypopharyngeal carcinoma. Methods: We retrospectively analyzed the clinical data of 11 patients with 13 superficial hypopharyngeal carcinomas who underwent ES D at the Gastrointestinal Endoscopy Center of Jiangsu Provincial Hospital of Traditional Chinese Medicine from November 2022 to November 2023 .  \nResults: All 11 patients were male, with 13 lesions located as follows: left pyriform fossa (53.8%), right pyriform fossa (23.1%), posterior hypopharyngeal wall (15.4%), and posterior cricoid region (7 .7%) . The average lesion diameter was 1 .79 cm (range: 0 .1–3. 9 cm) . The procedure took an average of 34 minutes (range: 10–90 minutes) . Intraoperatively, subcutaneous cervicothoracic emphysema occurred in 1 patient (7 .7%) . Postoperatively, 5 patients (38 . 5%) reported postoperative pain, and 1 patient (7 .7%) developed postoperative fever. During follow-up, choking symptoms were noted in 2 cases (18.2%), and hoarseness occurred in 4 cases (36 .4%) . The average length of hospitalization was 7 .3 days (range: 5–10 days) . Postoperative pathology revealed intraepithelial high-grade neoplasia in 46.2% of lesions, carcinoma in situ in 7 .7%, and invasive carcinoma in 46 . 2% . One case ofsquamous cell carcinoma had positive vertical margins, requiring additional radiotherapy and chemotherapy, while the remaining lesions had negative peripheral and basal margins. The mean follow-up period was 17 months (range: 9–25 months), with no recurrence, metastasis, or esophageal inlet stenosis observed in any patient.  \nConclusion: ESD is a safe and effective treatment for superficial hypopharyngeal carcinoma and can be considered a viable option for the m","cbCaikgRFRm8oKHS","https://ap.wps.com/l/cbCaikgRFRm8oKHS","pdf",2048496,"English","# Background\n## Objective\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What was the primary objective of the study?\",\"answer\":\"To evaluate the clinical efficacy and safety of endoscopic submucosal dissection (ESD) for superficial hypopharyngeal carcinoma.\"},{\"question\":\"How many patients and lesions were included, and how were they selected?\",\"answer\":\"Eleven male patients with superficial hypopharyngeal carcinoma and 13 lesions were retrospectively included; all underwent ESD from November 2022 to November 2023.\"},{\"question\":\"What were the key safety outcomes after ESD?\",\"answer\":\"Intraoperatively, subcutaneous cervicothoracic emphysema occurred in 1 patient. Postoperatively, postoperative pain occurred in 5 patients and fever in 1 patient.\"},{\"question\":\"What did follow-up show regarding recurrence or progression?\",\"answer\":\"The mean follow-up was 17 months, and no recurrence, metastasis, or esophageal inlet stenosis was observed in any patient.\"}]","Assessing the effectiveness of endoscopic submucosal dissection for hypopharyngeal lesions-a comprehensive evaluation | PDF",1790102904]