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A large prospective, hospital-based case-control study assessed whether regular low-dose aspirin use (80 mg, 5–7 tablets/week) is associated with PDAC risk. The analysis included PDAC cases and sex- and age-matched controls, adjusting odds ratios for key demographic and lifestyle confounders.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/aspirin-use-and-risk-of-pancreatic-ductal-adenocarcinoma-a-large-case-control-study/386500/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/aspirin-use-and-risk-of-pancreatic-ductal-adenocarcinoma-a-large-case-control-study/386500.png","ImageObject",300,407,{"name":92,"@type":93},"Mary Man","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main objective of the study?","Question",{"text":112,"@type":113},"To evaluate the association between regular low-dose aspirin use and the risk of pancreatic ductal adenocarcinoma (PDAC).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was low-dose aspirin use defined in the study?",{"text":117,"@type":113},"As 80-mg aspirin tablets taken 5–7 tablets per week.",{"name":119,"@type":110,"acceptedAnswer":120},"Did aspirin use reduce PDAC risk in the results?",{"text":121,"@type":113},"No. Ever aspirin use was not associated with PDAC risk (OR 1.01, 95% CI 0.89–1.14).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},386500,1790363007,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7421720224475,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","ARCHIVES OF  \nArch Iran Med. April 2023;26(4):181-185  IRANIAN  \ndoi 10 .34172/aim.2023.28 [http://journalaim.com](http://journalaim.com MEDICINE)[ MEDICINE](http://journalaim.com MEDICINE)  \n Original Article Open  \nAccess  \nAspirin Use and Risk of Pancreatic Ductal   \nAdenocarcinoma: A Large Case-Control Study  \nZahra Momayez Sanat, MD1 ID ; Sahar Masoudi, MSc1; Seidamir Pasha Tabaeian, MD2; Maryam Jameh Shorani, MD3;  \nMajid Soruri, MD1; Akram Pourshams, MD, MPH1,4,5* ID  \n1 Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran  \n2 Department of Internal Medicine, School of Medicine, Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran  \n3 Department of Internal Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran 4 Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran  \n5Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran  \nAbstract  \nBackground: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with a five-year survival rate of approximately 5% . The incidence and mortality rates of PDAC are increasing, and the results of medical treatments remain unsatisfactory. Some conflicting evidence suggests that aspirin intake may reduce the risk of PDAC. This study aimed to evaluate the association between regular low-dose aspirin use (80-mg aspirin tablets, 5-7 tablets/week) and the risk of PDAC.  \nMethods: This prospective, hospital-based, case-control study was performed on 470 PDAC patients (case group) and 526 sexand age-matched controls, in Tehran, Iran from 2011 to 2018. The participants were interviewed regarding the patterns of aspirin use. Data are expressed as mean ± SD or frequency and percentage as appropriate. Differences in frequency between the case and control groups were evaluated based on the analysis of the contingency table (χ2 test and Fisher’s exact test) . Propensity score models were designed to calculate odds ratios (OR) and 95% confidence intervals (95% CIs) for PDAC with respect to aspirin use, adjusted for age, sex, smoking status, opium use, diabetes mellitus, place of residence, and family history of cancer in first-degree relatives.  \nResults: About 60% of PDAC patients were male in this study. Also, 25.2% of PDAC patients had a family history of cancer in oneof their first-degree relatives, 21.99% were smokers, 13.9% were opium users, and 11.7% had a history of diabetes. Aspirin was used by 22.77% of PDAC patients and 18.25% of the controls. Ever aspirin use (OR: 1.01, 95% CI: 0.89 – 1.14) was not associated with PDAC.  \nConclusion: Overall, aspirin use was not associated with a reduced risk of PDAC.  \nKeywords: Aspirin, Case-control study, Pancreatic cancer, Pancreatic ductal adenocarcinoma  \nCite this article as: Momayez Sanat Z, Masoudi S, Tabaeian SP, Jameh Shorani M, Soruri M, Pourshams A. Aspirin use and risk of pancreatic ductal adenocarcinoma: a large case-control study. Arch Iran Med. 2023;26(4):181-185 . doi: 10.34172/aim.2023.28  \nReceived: October 4, 2022, Accepted: February 25, 2023, ePublished: April 1, 2023  \nIntroduction  \nPancreatic ductal adenocarcinoma (PDAC) is a deadly cancer, with rising incidence and mortality rates worldwide.1 In 2017, nearly 441000 deaths caused by PDAC were reported worldwide.1 There was a 2.3-fold increase in the global incidence and mortality of PDAC from 1990 to 2017, indicating both the aging and growth of the population and the increased prevalence of obesity and diabetes, which are two main risk factors for PDAC.2-4 The five-year survival rate of PDAC has slightly improved in the past four decades from 3% in 1970 to 5% today.5,6 PDAC is diagnosed frequently at an advanced stage when surgical resection is not possible, and chemoradiation is not effective enou","cbCaicoSBFvjDooS","https://ap.wps.com/l/cbCaicoSBFvjDooS","pdf",255469,"English","# Abstract\n# Introduction\n# Materials and Methods\n# Results\n# Conclusion","[{\"question\":\"What was the main objective of the study?\",\"answer\":\"To evaluate the association between regular low-dose aspirin use and the risk of pancreatic ductal adenocarcinoma (PDAC).\"},{\"question\":\"How was low-dose aspirin use defined in the study?\",\"answer\":\"As 80-mg aspirin tablets taken 5–7 tablets per week.\"},{\"question\":\"Did aspirin use reduce PDAC risk in the results?\",\"answer\":\"No. Ever aspirin use was not associated with PDAC risk (OR 1.01, 95% CI 0.89–1.14).\"}]","Aspirin Use and Risk of Pancreatic Ductal Adenocarcinoma - A Large Case-Control Study | PDF",1790274040,13]