[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-383388-105":59,"doc-detail-383388-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","arsenic-causing-gallbladder-cancer-disease-in-bihar","Arsenic causing gallbladder cancer disease in Bihar","","Gallbladder cancer incidences in India are increasing, with reports linking cases to arsenic hotspots in Bihar. The study evaluates arsenic exposure and gallbladder carcinogenesis using biological samples from 200 control volunteers and 152 confirmed gallbladder cancer cases, assessing gallbladder tissue, stone, bile, blood, and hair, alongside arsenic testing in blood from 512 cancer patients. Significantly higher arsenic concentrations appear in patient samples than controls, supporting a strong association between arsenic contamination and increased gallbladder cancer risk in exposed areas of Bihar.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/arsenic-causing-gallbladder-cancer-disease-in-bihar/383388/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/arsenic-causing-gallbladder-cancer-disease-in-bihar/383388.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study aiming to establish in relation to gallbladder cancer in Bihar?","Question",{"text":112,"@type":113},"The study aims to establish an association between arsenic exposure and gallbladder carcinogenesis in Bihar’s arsenic-exposed populations.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which biological samples were analyzed to estimate arsenic in gallbladder cancer patients?",{"text":117,"@type":113},"Gallbladder tissue, gallbladder stones, bile, blood, and hair samples were collected from gallbladder cancer patients and controls for arsenic estimation.",{"name":119,"@type":110,"acceptedAnswer":120},"What overall evidence did the study find about arsenic levels in patients compared with controls?",{"text":121,"@type":113},"Significantly higher arsenic concentrations were detected in blood and in multiple patient biological samples, indicating raised arsenic exposure in the studied gallbladder cancer cases.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383388,1790451258,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nArsenic causing gallbladder cancer disease in Bihar  \nArun Kumar1*, Mohammad Ali1, Vivek Raj1, Arti Kumari2, Mahesh Rachamalla3, Som Niyogi3, Dhruv Kumar4, Ashok Sharma5, Amit Saxena6, Ghanish Panjawani1, Preeti Jain1, Ajay Vidyarthi1, Navin Kumar1, Mukesh Kumar1, Pintoo Kumar Niraj1, Md. Samiur Rahman1, Akhouri Bishwapriya7, Ranjit Kumar8, Maiko Sakamoto9, Santosh Kumar10, Manisha Singh1 & Ashok Kumar Ghosh1  \nIn recent times Gallbladder cancer (GBC) incidences increased many folds in India and are being reported from arsenic hotspots identified in Bihar. The study aims to establish association between arsenic exposure and gallbladder carcinogenesis. In the present study, n = 200 were control volunteers and n = 152 confirmed gallbladder cancer cases. The studied GBC patient’s biological samples-gallbladder tissue, gallbladder stone, bile, blood and hair samples were collected for arsenic estimation. Moreover, n = 512 gallbladder cancer patients blood samples were also evaluated for the presence of arsenic to understand exposure level in the population. A significantly high arsenic concentration (p \u003C 0.05) was detected in the blood samples with maximum concentration 389 µg/Lin GBC cases in comparison to control. Similarly, in the gallbladder cancer patients, there was significantly high arsenic concentration observed in gallbladder tissue with highest concentration of 2166 µg/kg, in gallbladder stones 635 µg/kg, in bile samples 483 µg/L and in hair samples 6980 µg/ kg respectively. Moreover, the n = 512 gallbladder cancer patient’s blood samples study revealed very significant arsenic concentration in the population of Bihar with maximum arsenic concentration as  \n746 µg/L. The raised arsenic concentration in the gallbladder cancer patients’ biological samples—gallbladder tissue, gallbladder stone, bile, blood, and hair samples was significantly very high in the arsenic exposed area. The study denotes that the gallbladder disease burden is very high in the arsenic exposed area of Bihar. The findings do provide a strong link between arsenic contamination and increased gallbladder carcinogenesis.  \nAbbreviations  \nGBC Gall bladder cancer  \nICMR Indian Council of Medical Research  \nMMA Monomethylarsonous acid DMA Dimethylarsinic acid TMA Trimethylarsine  \nROS Reactive oxygen species  \nUSEPA U.S Environmental Protection Agency WHO World Health Organisation  \nGF-AAS Graphite Furnace Atomic Absorption Spectrophotometer PCA Principal component analysis  \nGallbladder cancer (GBC) is one of the rarest biliary tract malignancies with high mortality rate with relatively less survivability of 5 years1,2. Globally in year 2020, out of total cancer cases of 19,292,789, new GBC cases reported in the year was 115,949 while number of deceased cases were 84,6953. India accounts for 10% of global GBC cases, about one million new cancer cases every year with mortality rate as high as 33% every year4.  \n1Mahavir Cancer Sansthan and Research Centre, Patna, Bihar 801505, India. 2Department of Biotechnology, Patna Women’s College, Patna, Bihar, India. 3University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada. 4School of Health Sciences & Technology, UPES University, Dehradun, Uttrakhand, India. 5All India Institute of Medical Sciences, New Delhi, India. 6Centre for Development of Advanced Computing (C-DAC), Pune, Maharashtra, India. 7Geological Survey of India, Patna, Bihar, India. 8Central University of Himachal Pradesh, Kangra, India. 9University of Tokyo, Kashiwa, Japan. 10Delft University of Technology, Delft, The Netherlands. *email: [drarunk31@gmail.com](drarunk31@gmail.com)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \nAccording to Indian Council of Medical Research (ICMR), it is estimated that by the year 2025, there will be fivefold increase in cancer incidences in India, in which there will be 2 .8-fold increase due to tobacco whi","cbCaio258YGoQFzg","https://ap.wps.com/l/cbCaio258YGoQFzg","pdf",3479356,16,"English","# Background and study purpose\n## Study design and sample collection\n## Arsenic measurements and key findings\n## Disease burden and association conclusions\n## Abbreviations\n## Epidemiology and risk context","[{\"question\":\"What is the study aiming to establish in relation to gallbladder cancer in Bihar?\",\"answer\":\"The study aims to establish an association between arsenic exposure and gallbladder carcinogenesis in Bihar’s arsenic-exposed populations.\"},{\"question\":\"Which biological samples were analyzed to estimate arsenic in gallbladder cancer patients?\",\"answer\":\"Gallbladder tissue, gallbladder stones, bile, blood, and hair samples were collected from gallbladder cancer patients and controls for arsenic estimation.\"},{\"question\":\"What overall evidence did the study find about arsenic levels in patients compared with controls?\",\"answer\":\"Significantly higher arsenic concentrations were detected in blood and in multiple patient biological samples, indicating raised arsenic exposure in the studied gallbladder cancer cases.\"}]","Arsenic causing gallbladder cancer disease in Bihar | PDF",1790256473]