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High-frequency ARID1A alterations in human cancers underline its role in tumorigenesis, but its function varies by tumor type and context, acting as either tumor suppressor or oncogene. ARID1A is mutated in about 10% of tumor types, where loss can correlate with progression and worse prognostic features, though exceptions exist. The review summarizes evidence across cancers and discusses treatment strategies for ARID1A-mutated disease, including approaches based on synthetic lethality.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/arid1a-in-cancer-friend-or-foe-mini-review/385550/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/arid1a-in-cancer-friend-or-foe-mini-review/385550.png","ImageObject",300,407,{"name":92,"@type":93},"moss~","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is ARID1A’s physiological role in cells?","Question",{"text":112,"@type":113},"ARID1A is part of chromatin regulation machinery that helps maintain accessibility at promoters and enhancers, thereby regulating gene expression. Chromatin remodeling processes are required for activation or repression of gene expression during cell life, including development and differentiation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can ARID1A alterations influence cancer differently?",{"text":117,"@type":113},"The role of ARID1A varies by tumor type and context. ARID1A alterations may act as tumor suppressive or oncogenic, and ARID1A loss is often associated with disease progression, with some cancers showing worse prognostic features while exceptions have been reported.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is ARID1A loss considered relevant for therapeutic strategies?",{"text":121,"@type":113},"ARID1A loss of function is considered conducive to inhibitory drugs based on synthetic lethality mechanisms. 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Oncol. 13:1136248 .  \ndoi: 10.3389/fonc.2023.1136248  \nCOPYRIGHT  \n© 2023 Fontana, Gallerani, Salamon, Pace, Roncarati and Ferracin. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nARID1A in cancer: Friend or foe?  \nBeatrice Fontana 1†, Giulia Gallerani 1†, Irene Salamon 1†, Ilaria Pace 1, Roberta Roncarati 2* and Manuela Ferracin 1,3*  \n1 Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy, 2 Istituto di Genetica Molecolare ” Luigi Luca Cavalli-Sforza“ – Consiglio Nazionale delle Ricerce (CNR), Bologna, Italy, 3 IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy  \nARID1A belongs to a class of chromatin regulatory proteins that function by maintaining accessibility at most promoters and enhancers, thereby regulating gene expression. The high frequency of ARID1A alterations in human cancers has highlighted its significance in tumorigenesis. The precise role of ARID1A in cancer is highly variable since ARID1A alterations can have a tumor suppressive oroncogenic role, depending on the tumor type and context. ARID1A is mutated in about 10% of all tumor types including endometrial, bladder, gastric, liver, biliopancreatic cancer, some ovarian cancer subtypes, and the extremely aggressive cancers of unknown primary. Its loss is generally associated with disease progression more often than onset. In some cancers, ARID1A loss is associated with worse prognostic features, thus supporting a major tumor suppressive role. However, some exceptions have been reported. Thus, the association of ARID1A genetic alterations with patient prognosis is controversial. However, ARID1A loss of function is considered conducive for the use of inhibitory drugs which are based on synthetic lethality mechanisms. In this review we summarize the current knowledge on the role of ARID1A as tumor suppressor or oncogene in different tumor types and discuss the strategies for treating ARID1A mutated cancers.  \nKEYWORDS  \nARID1A, tumor suppressor gene, oncogene, solid tumors, SWI/SNF complex, synthetic lethality  \nIntroduction  \nPhysiological role of ARID1A  \nNucleosomes are composed of 147 base-pairs of DNA wrapped around histone octamers (1) and constitute the core unit of chromatin, which is further organized and compacted in higher order structures called topologically associated domains (TADs) in the nucleus (2, 3) . The chromatin needs to be dynamically remodeled to guarantee the activation or repression of gene expression during the entire life of the cell, but particularly during the embryonic development (4) and differentiation (5) . Remodeling means that regulatory complexes can be “opened” to provide access to the underlying DNA to enable transcription, chromatin assembl","cbCaip04zzDoRWdo","https://ap.wps.com/l/cbCaip04zzDoRWdo","pdf",872314,"English","# Introduction\n## Physiological role of ARID1A\n## SWI/SNF complex and ARID1A/ARID1B\n## ARID1A as a SWI/SNF component","[{\"question\":\"What is ARID1A’s physiological role in cells?\",\"answer\":\"ARID1A is part of chromatin regulation machinery that helps maintain accessibility at promoters and enhancers, thereby regulating gene expression. Chromatin remodeling processes are required for activation or repression of gene expression during cell life, including development and differentiation.\"},{\"question\":\"How can ARID1A alterations influence cancer differently?\",\"answer\":\"The role of ARID1A varies by tumor type and context. ARID1A alterations may act as tumor suppressive or oncogenic, and ARID1A loss is often associated with disease progression, with some cancers showing worse prognostic features while exceptions have been reported.\"},{\"question\":\"Why is ARID1A loss considered relevant for therapeutic strategies?\",\"answer\":\"ARID1A loss of function is considered conducive to inhibitory drugs based on synthetic lethality mechanisms. The review discusses strategies for treating ARID1A-mutated cancers in light of this concept.\"}]","ARID1A in cancer: Friend or foe? - Mini Review | PDF",1790269970,25]