[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331644-105":59,"doc-detail-331644-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","are-hpv-oncogenic-viruses-involved-in-salivary-glands-tumorigenesis","Are HPV oncogenic viruses involved in salivary glands tumorigenesis?","","The association between oncogenic viruses and cancer is widely recognized, yet the mechanisms by which they contribute to salivary gland (SG) tumor development remain incompletely understood. This narrative review evaluates current literature on SG cancer and examines whether human papillomaviruses (HPVs) are involved, proposing a possible role in tumor immunogenicity. Evidence indicates HPV-positive detection across multiple head and neck malignancies and highlights E6/E7-mediated tumorigenesis, with strongest support for high-risk HPV 16 and 18. Contributions from other subtypes are debated and require further study, informing etiopathogenic co-factor models and potential prevention or therapy strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/are-hpv-oncogenic-viruses-involved-in-salivary-glands-tumorigenesis/331644/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/are-hpv-oncogenic-viruses-involved-in-salivary-glands-tumorigenesis/331644.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of the review?","Question",{"text":112,"@type":113},"To update knowledge on pathological mechanisms in salivary gland malignancies and assess potential viral involvement in their etiopathogenesis, focusing on HPV.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do E6 and E7 HPV oncoproteins relate to tumorigenesis?",{"text":117,"@type":113},"The review describes HPV tumorigenesis as complex and mediated through E6 and E7 oncoproteins.",{"name":119,"@type":110,"acceptedAnswer":120},"Which HPV subtypes show the strongest support in salivary gland cancer findings?",{"text":121,"@type":113},"Reported findings generally support an association between salivary gland cancer and high oncogenic subtypes 16 and 18.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331644,1790012791,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","REVIEW  \nR J M E  \nRomanian Journal of Morphology & Embryology  \n[http://www.rjme.ro/](http://www.rjme.ro/)  \nAre HPV oncogenic viruses involved in salivary glands tumorigenesis?  \nCONSTANTIN ALEODOR COSTIN1), MARIANA BIANCA CHIFU1), DIANA LAVINIA PRICOPE1), ADRIANA GRIGORAŞ1,2), RALUCA ANCA BALAN1,3), CORNELIA AMĂLINEI1,2)  \n1) Department of Morphofunctional Sciences I, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania  \n2) Department of Histopathology, Institute of Legal Medicine, Iaşi, Romania  \n3) Department of Pathology, Elena Doamna Clinical Hospital of Obstetrics and Gynecology, Iaşi, Romania  \nAbstract  \nThe association between different viruses and cancer is well acknowledged in human pathology. However, the precise understanding of how oncogenic viruses intervene in the development of cancer of salivary glands (SGs) remains incomplete. Our review aimed to explore the current literature regarding SGs cancer to evaluate the potential involvement of human papillomaviruses (HPVs) in their development. Our work hypothesis suggests that viruses may be involved in these tumors’immunogenicity. The literature analysis showed HPV-positive detection in different head and neck malignancies, added to variable risk factors and a constant increasing incidence rate. HPV tumorigenesis mechanism is complex, involving E6 and E7 HPV oncoproteins. Additionally, the reported findings generally support the relationship between SGs cancer and high oncogenic subtypes 16 and 18. However, the pathogenic contribution of HPV subtypes 11, 33, 45, 52, 56, and 59 is controversial and further research may clarify their potential involvement in the SG tumor’s development. This literature review may enhance the understanding of the role of viral contribution as an etiopathogenic co-factor in SG carcinogenesis. Thus, these data may add value to innovative concepts and treatment strategies development, given that virus-induced tumors can be prevented by targeted immunization, added to oncolytic or viral therapy.  \nKeywords: human papillomaviruses, salivary gland tumors, virus-induced tumors, E6, E7, HR-HPV.  \n􀀕 Introduction  \nSalivary gland (SG) tumors constitute a heterogeneous spectrum of neoplasms with variable behavior, characterized by intricate clinicopathological and biological features. This diversity raises significant challenges for pathologists and clinicians in SG tumors management. SG tumors represent a small percentage of all malignancies, ranging from 0.5% to 1.2%, and contribute to approximately 6% to 8% of all head and neck malignancies [1, 2] . The annual incidence is variable, being estimated to be 0.69 cases per 100 000 people in Europe and raising up to 1.1 cases per 100 000 in the United States [3] . These variations can be attributed to different population characteristics, such as diet and occupational exposures, as well as diagnostic and reporting practices and active national cancer registries [1, 3] .  \nThe most recent classification of head and neck tumors includes 24 malignancies, added to another type with uncertain malignant potential, while the World Health Organization (WHO) classification of head and neck tumors, in its fifth edition, adds two more malignant entities, microsecretory adenocarcinoma (MSA) and sclerosing microcystic adenocarcinoma (SMA), respectively [4] .  \nRegarding histopathological features, mucoepidermoid carcinoma (MEC) has the highest incidence in SG malignancies, accounting for 30–40% of all SG cancers, followed by acinic cell carcinoma (ACC), with a rate of approximately 12%, in both pediatric and adult populations  \n[2, 5, 6] . The most common MEC location is the parotid gland (PG), but it can also develop in other sites, such as the sublingual and submandibular glands, along with sinonasal cavities minor SGs, oropharynx, or oral cavity [5]. Adenoid cystic carcinoma (AdCC) represents approximately a quarter of the primary carcinomas ofthe SG carcinomas and can arise in both minor","cbCaimf767GuhqZU","https://ap.wps.com/l/cbCaimf767GuhqZU","pdf",867153,13,"English","# Introduction\n## Risk factors of salivary glands cancer","[{\"question\":\"What is the main purpose of the review?\",\"answer\":\"To update knowledge on pathological mechanisms in salivary gland malignancies and assess potential viral involvement in their etiopathogenesis, focusing on HPV.\"},{\"question\":\"How do E6 and E7 HPV oncoproteins relate to tumorigenesis?\",\"answer\":\"The review describes HPV tumorigenesis as complex and mediated through E6 and E7 oncoproteins.\"},{\"question\":\"Which HPV subtypes show the strongest support in salivary gland cancer findings?\",\"answer\":\"Reported findings generally support an association between salivary gland cancer and high oncogenic subtypes 16 and 18.\"}]","Are HPV oncogenic viruses involved in salivary glands tumorigenesis? | PDF",1789994426,33]