[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-406679-105":59,"doc-detail-406679-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","are-aspects-of-integrative-concepts-helpful-to-improve-pancreatic-cancer-therapy-an-overview","Are Aspects of Integrative Concepts Helpful to Improve Pancreatic Cancer Therapy - An Overview","","Numerous clinical studies aim to improve outcomes for pancreatic cancer patients by exploring targeted therapies and precision-medicine strategies, including potential synergies with integrative approaches. Pancreatic tumors face a major obstacle: an immune-controlled tumor microenvironment with dense stroma, which limits drug penetration and drives immunological tolerance. Combinations of standard oncological treatment with hyperthermia, irreversible electroporation, intra-tumoral injections, phytotherapeutics, or vitamins are being evaluated in ongoing clinical trials, with an overview provided here.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/are-aspects-of-integrative-concepts-helpful-to-improve-pancreatic-cancer-therapy-an-overview/406679/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/are-aspects-of-integrative-concepts-helpful-to-improve-pancreatic-cancer-therapy-an-overview/406679.png","ImageObject",300,407,{"name":92,"@type":93},"ahduag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is pancreatic cancer treatment difficult even with standard therapies?","Question",{"text":112,"@type":113},"Pancreatic tumors develop within a microenvironment and dense stroma that acts as a physical barrier to drug penetration and is regulated by the immune system, promoting immunological tolerance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What integrative modalities are discussed alongside standard oncological therapy?",{"text":117,"@type":113},"The review presents evidence-based options such as hyperthermia, percutaneous irreversible electroporation, intra-tumoral injections, phytochemical/phytotherapeutic preparations, and vitamins.",{"name":119,"@type":110,"acceptedAnswer":120},"How are combined standard-oncological and integrative methods being evaluated?",{"text":121,"@type":113},"The combined use of standard oncological and integrative approaches is currently under study in ongoing clinical trials, and the article provides an overview of the evidence and approaches.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406679,1791120693,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},3985747870414,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","cancers   \nReview  \nAre Aspects of Integrative Concepts Helpful to Improve Pancreatic Cancer Therapy?  \nShiao Li Oei 1 and Friedemann Schad 1,2, *  \nCitation: Oei, S.L.; Schad, F. Are Aspects of Integrative Concepts Helpful to Improve Pancreatic Cancer Therapy? Cancers 2023, 15, 1116. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15041116  \nAcademic Editor: David Wong  \nReceived: 29 December 2022  \nRevised: 24 January 2023  \nAccepted: 7 February 2023  \nPublished: 9 February 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Network Oncology, Research Institute Havelhöhe, Kladower Damm 221, 14089 Berlin, Germany  \n2 Department of Interdisciplinary Oncology and Palliative Care, Hospital Gemeinschaftskrankenhaus Havelhöhe, Kladower Damm 221, 14089 Berlin, Germany  \n* Correspondence: fschad@havelhoehe.de  \nSimple Summary: Pancreatic carcinoma is one of the malignancies with the highest cancer-specific mortality. While invading the microenvironment and the dense stroma, the immune system plays a key role in the pathological development, as well as in the treatment of pancreatic tumors. In this review, evidence-based treatment options, including standard oncological treatment and integrative therapies, such as hyperthermia, electroporation, intra-tumoral injections, phytochemical preparations or vitamins to improve the prognosis of patients with pancreatic cancer, are presented and discussed.  \nAbstract: Numerous clinical studies have been conducted to improve the outcomes of patients suffering from pancreatic cancer. Different approaches using targeted therapeutic strategies and precision medicine methods have been investigated, and synergies and further therapeutic advances may be achieved through combinations with integrative methods. For pancreatic tumors, a particular challenge is the presence of a microenvironment and a dense stroma, which is both a physical barrier to drug penetration and a complex entity being controlled by the immune system. Therefore, the state of immunological tolerance in the tumor microenvironment must be overcome, which is a considerable challenge. Integrative approaches, such as hyperthermia, percutaneous irreversible electroporation, intra-tumoral injections, phytotherapeutics, or vitamins, in combination with standard-oncological therapies, may potentially contribute to the control of pancreatic cancer. The combined application of standard-oncological and integrative methods is currently being studied in ongoing clinical trials. An actual overview is given here.  \nKeywords: ascorbate; curcumin; irreversible electroporation; hyperthermia; microenvironment; mistletoe; nanocarriers; pancreatic carcinoma; paricalcitol  \n1. Introduction  \nPancreatic carcinoma (PC) is one of the malignancies with the highest cancer-specific mortality [1] . PC is characterized by an extensive fibrotic stroma, including an extracellular matrix, elevated levels of cytokines and growth factors, activated pancreatic stellate cells (PSCs), cancer-associated fibroblasts, and also cancer stem cells. Patients with PC are often classified into one of four categories based on the extent of the disease: resectable, borderline resectable, locally advanced, and metastatic. Surgery, followed by adjuvant chemotherapy, is the only potentially curative treatment for PC, but only 15–20% of patients are candidates for surgery. Numerous different studies have been conducted to prolong the overall survival of PC patients using adjuvant, neoadjuvant, and combined therapeutic strategies [2] . Even if PC occurs relatively rarely, for example in Germany PC accounts for only about four percent of all","cbCaijrhy4P9jSHI","https://ap.wps.com/l/cbCaijrhy4P9jSHI","pdf",1531641,22,"English","# 1. Introduction\n## Pancreatic carcinoma overview and treatment challenges\n# 2. Integrative concepts in pancreatic cancer therapy\n## Hyperthermia and percutaneous irreversible electroporation\n## Intra-tumoral injections, phytotherapeutics, and vitamins","[{\"question\":\"Why is pancreatic cancer treatment difficult even with standard therapies?\",\"answer\":\"Pancreatic tumors develop within a microenvironment and dense stroma that acts as a physical barrier to drug penetration and is regulated by the immune system, promoting immunological tolerance.\"},{\"question\":\"What integrative modalities are discussed alongside standard oncological therapy?\",\"answer\":\"The review presents evidence-based options such as hyperthermia, percutaneous irreversible electroporation, intra-tumoral injections, phytochemical/phytotherapeutic preparations, and vitamins.\"},{\"question\":\"How are combined standard-oncological and integrative methods being evaluated?\",\"answer\":\"The combined use of standard oncological and integrative approaches is currently under study in ongoing clinical trials, and the article provides an overview of the evidence and approaches.\"}]","Are Aspects of Integrative Concepts Helpful to Improve Pancreatic Cancer Therapy - An Overview | PDF",1790567243,55]