[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-628502-105":59,"doc-detail-628502-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","applying-newer-parameter-ret-he-to-assess-latent-iron-deficiency-in-blood-donors-study-at-a-tertiary-care-hospital-in-india","Applying newer parameter Ret-He to assess latent iron deficiency in blood donors - study at a tertiary care hospital in India","","Applying Reticulocyte Hemoglobin Equivalent (Ret-He) evaluates whether a newer hematological parameter can detect latent iron deficiency (LID) in blood donors. The randomized prospective study includes 501 donor samples and compares Ret-He with soluble transferrin receptor (sTfR), the current gold standard. Ret-He demonstrates high sensitivity, specificity, and predictive values, outperforming serum ferritin, total iron-binding capacity, and serum iron. Ret-He supports routine screening, enabling timely dietary or drug interventions to prevent progression to overt iron deficiency anemia.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/applying-newer-parameter-ret-he-to-assess-latent-iron-deficiency-in-blood-donors-study-at-a-tertiary-care-hospital-in-india/628502/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/applying-newer-parameter-ret-he-to-assess-latent-iron-deficiency-in-blood-donors-study-at-a-tertiary-care-hospital-in-india/628502.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-10-21",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is latent iron deficiency (LID) important to detect in blood donors?","Question",{"text":112,"@type":113},"LID represents iron deficiency without overt anemia (normal hemoglobin). People with LID are more likely to develop iron deficiency anemia within weeks or months if not managed with diet changes and/or iron supplementation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was Ret-He evaluated in the study?",{"text":117,"@type":113},"The study compared Ret-He measured on a hematology analyzer (including Sysmex XE-2100) with sTfR measured by ELISA. Ret-He and sTfR thresholds were used to diagnose LID, alongside simultaneous measurement of serum iron, TIBC, and ferritin.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings on diagnostic performance?",{"text":121,"@type":113},"Ret-He detected LID in 135 of 501 donors and, relative to sTfR, showed sensitivity of 92.7% and specificity of 97.16%, with high PPV and NPV. Serum ferritin, TIBC, and serum iron had lower sensitivity values.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},628502,1793000743,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","|  |  |\n| --- | --- |\n| Vox Sanguinis (2018) |  |\n| \u003Cbr>ORIGINAL PAPER\u003Cbr>© 2018 International\u003Cbr>Society of Blood Transfusion DOI: 10.1111/vox.12700\u003Cbr>Applying newer parameter Ret-He (reticulocyte haemoglobin equivalent) to assess latent iron deficiency (LID) in blood donors–study at a tertiary care hospital in India\u003Cbr>Aseem K Tiwari, 1  Gunjan Bhardwaj, 1 Dinesh Arora, 1 Geet Aggarwal, 1 Swati Pabbi, 1 Ravi C Dara,1 Ritesh Sachdev,2 Arun Raizada3 & Monisha Sethi4\u003Cbr>1Department of Transfusion Medicine, Medanta-The Medicity, Gurgaon, India 2Department of Pathology & Lab Medicine, Medanta-The Medicity, Gurgaon, India 3Department of Biochemistry, Medanta-The Medicity, Gurgaon, India\u003Cbr>4Scientific Affair & Application Support, Sysmex India Pvt. Ltd., Delhi, India |  |\n| \u003Cbr>Received: 19 March 2018, revised 28 June 2018, accepted 6 July 2018 | Background It is important to detect Latent Iron Deficiency (LID) to prevent development of an overt iron deficiency anemia. Early detection is difficult by using conventional hematological and biochemical parameters. Soluble transferrin receptor (sTfR) is presently the gold standard for diagnosing LID. We evaluated the utility of Reticulocyte Hemoglobin Equivalent (Ret-He), a newer hematological parameter, to predict LID in blood donors as compared to sTfR.\u003Cbr>Methods This was a randomized prospective study performed on 501 donor samples over a period of three-months. All donors were included after administering medical history questionnaire and a brief physical examination in accordance with national guidelines (Hb 􀀁12 .5) . Additional samples were collected during donation according to the institutional standard operating procedure (SOP) . All hemograms were performed on the Sysmex XE-2100 analyzer which included RetHe. sTfR was measured in batch assays by ELISA (Biovendor, Czech Republic) . Ret He \u003C28 pg and sTfR􀀁3lg/ml were used to diagnose LID. Serum Iron, Total Iron Binding Capacity (TIBC) and Serum Ferritin were also measured simultaneously.\u003Cbr>Results Of the 501 blood donors, sTfR and Ret-He detected LID in 148 and 135 donors respectively. In comparison to sTfR, Ret-He had sensitivity of 92.7%, aspecificity of 97.16%, PPV of 93.1% and NPV of 96.3% . Serum Ferritin, TIBCand serum Iron had comparatively lower sensitivity of 87.16%, 79.7% and 77.7% respectively.\u003Cbr>Conclusion Ret-He can be used as a routine screening test to detect LID in blood donors. This could provide an opportunity to make appropriate and timely interventions like dietary changes or drug supplementation.\u003Cbr>Key words: blood donors, latent iron deficiency, reticulocyte haemoglobin equivalent (Ret-He), serum ferritin, serum transferrin receptor (sTfR) . |\n\nIntroduction  \nAccording to World Health Organization (WHO), anaemia can be defined as a condition in which the number of red  \nCorrespondence: Aseem K Tiwari, Director, Department of Transfusion Medicine, Medanta-The Medicity, Sector-38, Gurgaon-122001, India E-mail: [aseemtwr@yahoo.co.in](aseemtwr@yahoo.co.in)  \nblood cells or their oxygen-carrying capacity is insufficient to meet the physiological needs of the body [1] . Clinical features of anaemia may vary according to age, gender, altitude, smoking or pregnancy status. Globally, the commonest cause of anaemia is iron deficiency [1] . However, other nutritional deficiencies such as folate, vitamin B 12 and vitamin A deficiencies, chronic inflammatory conditions, parasitic infections or inherited  \ndisorders can also lead to anaemia. In India, iron deficiency is the most widespread micronutrient deficiency causing anaemia and affecting all age groups irrespective of gender, cast, creed and religion [2] . Several studies from India shows high incidence of iron deficiency anaemia (IDA) among blood donors especially regular blood donors [3, 4]  \nIt is important to assess not just overt anaemia but even the latent iron deficiency (LID) which is iron deficiency without anaemia (normal haemoglobin) . The importance lies in the fac","cbCaiaINoX3MfltF","https://ap.wps.com/l/cbCaiaINoX3MfltF","pdf",147491,"English","# Background\n# Methods\n# Results\n# Conclusion\n# Introduction\n# Materials and methods\n## Settings\n## Subjects","[{\"question\":\"Why is latent iron deficiency (LID) important to detect in blood donors?\",\"answer\":\"LID represents iron deficiency without overt anemia (normal hemoglobin). People with LID are more likely to develop iron deficiency anemia within weeks or months if not managed with diet changes and/or iron supplementation.\"},{\"question\":\"How was Ret-He evaluated in the study?\",\"answer\":\"The study compared Ret-He measured on a hematology analyzer (including Sysmex XE-2100) with sTfR measured by ELISA. Ret-He and sTfR thresholds were used to diagnose LID, alongside simultaneous measurement of serum iron, TIBC, and ferritin.\"},{\"question\":\"What were the main findings on diagnostic performance?\",\"answer\":\"Ret-He detected LID in 135 of 501 donors and, relative to sTfR, showed sensitivity of 92.7% and specificity of 97.16%, with high PPV and NPV. Serum ferritin, TIBC, and serum iron had lower sensitivity values.\"}]","Applying newer parameter Ret-He to assess latent iron deficiency in blood donors - study at a tertiary care hospital in India | PDF",1792616794]