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Integration of 3D cell models with 3D bioprinting may support precision medicine and immunotherapy by tailoring model attributes to individual patients.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},380480,1790472430,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":131,"language":132,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":67,"update_tm":136,"read_time":36},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Heliyon 9 (2023) e20475  \nContents lists available at ScienceDirect  \nHeliyon  \njournal [homepage:](homepage: www.cell.com/heliyon)[ www.cell.com/heliyon](homepage: www.cell.com/heliyon)  \n| Review article\u003Cbr>Application of three-dimensional (3D) bioprinting in anti-cancer therapy\u003Cbr>Bing-Xuan Wu a, Zheng Wu b, c, Yan-Yu Hou b, c, Ze-Xuan Fangb, c, Yu Denga, Hua-Tao Wu a, **, Jing Liu b, c, *\u003Cbr>a Department of General Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China b The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China\u003Cbr>c Department of Physiology/Changjiang Scholar’s Laboratory, Shantou University Medical College, Shantou 515041, China |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>3D bioprinting cancer Bioink Therapy Organic |  | Three-dimensional (3D) bioprinting is a novel technology that enables the creation of 3D structures with bioinks, the biomaterials containing living cells. 3D bioprinted structures can mimic human tissue at different levels of complexity from cells to organs. Currently, 3D bioprinting is a promising method in regenerative medicine and tissue engineering applications, as well as in anticancer therapy research. Cancer, a type of complex and multifaceted disease, presents significant challenges regarding diagnosis, treatment, and drug development. 3D bioprinted models of cancer have been used to investigate the molecular mechanisms of oncogenesis, the development of cancers, and the responses to treatment. Conventional 2D cancer models have limitations in predicting human clinical outcomes and drug responses, while 3D bioprinting offers an innovative technique for creating 3D tissue structures that closely mimic the natural characteristics of cancers in terms of morphology, composition, structure, and function. By precise manipulation of the spatial arrangement of different cell types, extracellular matrix components, and vascular networks, 3D bioprinting facilitates the development of cancer models that are more accurate and representative, emulating intricate interactions between cancer cells and their surrounding microenvironment. Moreover, the technology of 3D bioprinting enables the creation of personalized cancer models using patient-derived cells and biomarkers, thereby advancing the fields of precision medicine and immunotherapy. The integration of 3D cell models with 3D bioprinting technology holds the potential to revolutionize cancer research, offering extensive flexibility, precision, and adaptability in crafting customized 3D structures with desired attributes and functionalities. In conclusion, 3D bioprinting exhibits significant potential in cancer research, providing opportunities for identifying therapeutic targets, reducing reliance on animal experiments, and potentially lowering the overall cost of cancer treatment. Further investigation and development are necessary to address challenges such as cell viability, printing resolution, material characteristics, and cost-effectiveness. With ongoing progress, 3D bioprinting can significantly impact the field of cancer research and improve patient outcomes. |\n\n* Corresponding author. Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515041, Guangdong Province, China.  \n** Corresponding author. Department of General Surgery, the First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515041, Guangdong Province, China.  \n[E-mail addresses:](E-mail addresses: htwu@stu.edu.cn)[ htwu@stu.edu.cn](E-mail addresses: htwu@stu.edu.cn) (H.-T. Wu), [jliu12@stu.edu.cn](jliu12@stu.edu.cn) (J. Liu).  \n[https://doi.org/10.1016/j.heliyon.2023.e20475](https://doi.org/10.1016/j.heliyon.2023.e20475)  \nReceived 30 August 2023; Accepted 26 September 2023  \nAvailable onlin","cbCainAWiNuc9v1h","https://ap.wps.com/l/cbCainAWiNuc9v1h","pdf",2643806,16,"English","# Introduction\n## 3D bioprinting as an emerging technology\n## Applications in cancer research","[{\"question\":\"What benefits does 3D bioprinting offer for precision medicine and immunotherapy?\",\"answer\":\"Using patient-derived cells and biomarkers, the technology enables personalized cancer models. Integration of 3D cell models with 3D bioprinting may support precision medicine and immunotherapy by tailoring model attributes to individual patients.\"}]","Application of three-dimensional (3D) bioprinting in anti-cancer therapy | PDF",1790240369]