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This review summarizes recent progress in intelligent, responsive fluorescent probes for breast cancer, organizing them into five mechanism-based categories and linking each type to distinct biological response value.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/application-of-intelligent-response-fluorescent-probe-in-breast-cancer-review/331339/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/application-of-intelligent-response-fluorescent-probe-in-breast-cancer-review/331339.png","ImageObject",300,407,{"name":42,"@type":43},"Miles","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is early detection especially important in breast cancer?","Question",{"text":63,"@type":64},"Breast cancer is a major cause of cancer-related death among women, and advanced cases are often difficult to treat. Early diagnosis and intervention are emphasized to improve outcomes.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is the role of fluorescent probe technology in breast cancer imaging?",{"text":68,"@type":64},"Fluorescent probe technology is presented as a revolutionary in vivo imaging tool that can significantly improve tumor visualization, supporting early diagnosis efforts.",{"name":70,"@type":61,"acceptedAnswer":71},"How does the review categorize intelligent response fluorescent probes for breast cancer?",{"text":72,"@type":64},"The review divides intelligent, responsive fluorescent probes into five categories based on biological response mechanisms: near-infrared responsive, fluorescein-labeled, pH-responsive, redox-dependent, and enzyme-triggered probes.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331339,1790244167,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","molecules   \nReview  \nApplication of Intelligent Response Fluorescent Probe in Breast Cancer  \nAnqi Sheng 1,2, Hao Zhang 1, Qing Li 2, Shu Chen 2 and Qingshuang Wang 1, *  \nCitation: Sheng, A.; Zhang, H.; Li, Q.; Chen, S.; Wang, Q. Application of Intelligent Response Fluorescent Probe in Breast Cancer. Molecules 2024, 29, 4294. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)molecules29184294  \nAcademic Editor: Elisa Nuti  \nReceived: 19 August 2024  \nRevised: 8 September 2024  \nAccepted: 9 September 2024  \nPublished: 10 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 College of Life Science and Technology, Changchun University of Science and Technology, Changchun 130013, China; [saq1988@126.com](saq1988@126.com) (A.S.); [zhanghao@cust.edu.cn](zhanghao@cust.edu.cn) (H.Z.)  \n2 Technology Innovation Institute of Jilin Province, Changchun 130012, China; [13944832718@163.com](13944832718@163.com) (Q.L.); [chenshu7381@163.com](chenshu7381@163.com) (S.C.)  \n* [Correspondence: wangqingshuang@163.com](Correspondence: wangqingshuang@163.com); Tel.: +86-158-4312-9007  \nAbstract: As one of the leading cancers threatening women’s lives and health, breast cancer is challenging to treat and often irreversible in advanced cases, highlighting the critical importance of early detection and intervention. In recent years, fluorescent probe technology, a revolutionary in vivo imaging tool, has gained attention in medical research for its ability to improve tumor visualization significantly. This review focuses on recent advances in intelligent, responsive fluorescent probes, particularly in the field of breast cancer, which are divided into five categories, near-infrared responsive, fluorescein-labeled, pH-responsive, redox-dependent, and enzyme-triggered fluorescent probes, each of which has a different value for application based on its unique biological response mechanism. In addition, this review also covers the strategy of combining fluorescent probes with various anti-tumor drugs, aiming to reveal the possibility of synergistic effects between the two in breast cancer treatment and provide a solid theoretical platform for the clinical translation of fluorescent probe technology, which is expected to promote the expansion of cancer treatment technology.  \nKeywords: synthesis; fluorescent probes; application; breast cancer  \n1. Introduction  \nBreast cancer poses a significant threat to women’s health, being the most prevalent form of cancer and one of the leading causes of cancer-related deaths among women [1,2] . It affects women globally, irrespective of age, with its incidence increasing as age advances. Breast cancers are classified based on the expression of estrogen receptors (ERs), progesterone receptors (PRs), and human epithelial growth factor receptor 2 (HER2) into three categories: hormone receptor-positive (ER+, PR+, HER2 − ), HER2 − rich (ER − , PR − , HER2+ ), and triple-negative (ER − , PR − , HER2 − ) [3,4] . Notably, over 90% of breast cancer diagnoses reveal non-disseminated tumors at the initial clinical evaluation. For patients without evident distant metastases, therapeutic interventions primarily focus on the complete eradication of the malignant growth and the prevention of recurrence. Triple-negative breast cancer demonstrates a markedly higher susceptibility to recurrence compared to other subtypes. This is supported by a 5-year survival rate of 85% for individuals diagnosed with stage I breast cancer, which contrasts significantly with the 94% to 99% survival rates reported for hormone receptor-positive and ERBB2-positive patient cohorts. In the context of meta","cbCaiiKP0gOzTrLo","https://ap.wps.com/l/cbCaiiKP0gOzTrLo","pdf",5168282,17,"English","# Abstract\n# Introduction\n## Breast cancer classification and clinical challenges\n## Imaging modalities and their limitations\n# Fluorescent probe technology in early diagnosis","[{\"question\":\"Why is early detection especially important in breast cancer?\",\"answer\":\"Breast cancer is a major cause of cancer-related death among women, and advanced cases are often difficult to treat. Early diagnosis and intervention are emphasized to improve outcomes.\"},{\"question\":\"What is the role of fluorescent probe technology in breast cancer imaging?\",\"answer\":\"Fluorescent probe technology is presented as a revolutionary in vivo imaging tool that can significantly improve tumor visualization, supporting early diagnosis efforts.\"},{\"question\":\"How does the review categorize intelligent response fluorescent probes for breast cancer?\",\"answer\":\"The review divides intelligent, responsive fluorescent probes into five categories based on biological response mechanisms: near-infrared responsive, fluorescein-labeled, pH-responsive, redox-dependent, and enzyme-triggered probes.\"}]","Application of Intelligent Response Fluorescent Probe in Breast Cancer - Review | PDF",1789992733,43]