[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-460652-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-460652-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","application-of-contrast-enhanced-ultrasound-combined-with-ultrahigh-frequency-ultrasound-in-lymphaticovenous-anastomosis","Application of contrast-enhanced ultrasound combined with ultrahigh-frequency ultrasound in lymphaticovenous anastomosis","","Secondary lymphedema severely affects quality of life, and lymphaticovenous anastomosis (LVA) depends on precise preoperative identification of functional lymphatic vessels (LVs) and accurate internal diameter measurement. This retrospective study evaluates whether combining contrast-enhanced ultrasound (CEUS) with ultrahigh-frequency ultrasound (UHFUS) improves functional LV localization and diameter quantification compared with CEUS alone or UHFUS alone. In 24 female patients, CEUS located more functional LVs faster, while UHFUS measured diameters more accurately; the combined approach delivered both benefits, streamlining LVA and improving efficiency.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/application-of-contrast-enhanced-ultrasound-combined-with-ultrahigh-frequency-ultrasound-in-lymphaticovenous-anastomosis/460652/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/application-of-contrast-enhanced-ultrasound-combined-with-ultrahigh-frequency-ultrasound-in-lymphaticovenous-anastomosis/460652.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What clinical problem does the study address in LVA planning?","Question",{"text":62,"@type":63},"Successful LVA requires preoperative identification of functional lymphatic vessels and accurate measurement of their internal diameters; current single imaging approaches struggle to localize functional LVs and measure diameters accurately at the same time.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How were patients grouped in the retrospective study?",{"text":67,"@type":63},"Twenty-four female patients with secondary extremity lymphedema underwent three localization methods: CEUS combined with UHFUS (Group A), CEUS alone (Group B), and UHFUS alone (Group C).",{"name":69,"@type":60,"acceptedAnswer":70},"What is the main finding about the combined CEUS+UHFUS approach?",{"text":71,"@type":63},"The combined approach rapidly located more functional LVs and also measured LV internal diameters more accurately than either CEUS alone or UHFUS alone, improving procedural efficiency.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},460652,1792238513,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nApplication of contrast-enhanced ultrasound combined with ultrahigh-frequency ultrasound in lymphaticovenous anastomosis  \nXing Huang1,7, Yuanyan Tang2,7, Zhongzeng Liang3,7, Jia Zhu4, Xiaoting Yu4, Caigang Liu5,6 & Zhengren Liu4􀀍  \nPreoperative identification of functional lymphatic vessels (LVs) and accurate measurement of their internal diameters can facilitate lymphaticovenous anastomosis (LVA) . However, current single imaging methods cannot accurately measure LVs internal diameters while locating functional LVs. This study aims to demonstrate the accuracy and effectiveness of combining contrast-enhanced ultrasound (CEUS) with ultra-high-frequency ultrasound (UHFUS) for precisely locating functional LVs and measuring internal diameters. 24 patients with secondary upper or lower extremity lymphedema were included in this retrospective study, who underwent three localization methods respectively: CEUS combined with UHFUS (Group A), CEUS alone (Group B), and UHFUS alone (Group C) . 24 patients were all female (mean age, 61.9 ± 7.1 years [SD]). Compared with UHFUS, CEUS can locate more functional LVs more quickly (3.00 (2.00,3.00) number vs. 5.88 ± 1.25 number, P \u003C 0.001b, 36.43 ± 8.62 min/each vs. 8.45 ± 4.25 min/each, P \u003C 0.001b ) . UHFUS can measure internal diameters of LVs more accurately compared toCEUS (0.10(0.10,0.10) mm vs. 0.30(0.20,0.34) mm, P\u003C 0.001b ) . Compared with CEUS alone, CEUS combined with UHFUS can measure internal diameters of LVs more accurately on the basis of quickly locating functional LVs (0.10 (0.10,0.10) mm vs. 0.30(0.20,0.34) mm P \u003C 0.001b ) .  \nCEUS combined with UHFUS can locate more functional LVs more quickly compared to UHFUS alone (5 .25 ± 0.89 number vs. 3.00 (2 .00,3 .00) number, P \u003C 0.001b, 9.88 ± 4.21 min/each vs. 36.43 ± 8.62 min/ each, P \u003C 0.001b ). The integrated approach combined the advantages of both CEUS and UHFUS. It can not only rapidly localize functional LVs, but also accurately measure internal diameters, which streamlines LVA and improves efficiency.  \nKeywords Contrast-enhanced ultrasound, Ultrahigh-frequency ultrasonographic, Lymphaticovenous anastomosis, Contrast enhanced ultrasound combined with ultra-high frequency ultrasound  \nAbbreviations  \nLVs lymphatic vessels  \nLVA lymphaticovenous anastomosis TVs target veins  \nCEUS contrast-enhanced ultrasound  \nUHFUS ultra-high frequency ultrasound ICG Indocyanine green  \nMRI magnetic resonance imaging  \nISL lymphatic Society stage  \n1Department of Ultrasound Medicine, Affiliated Hospital of Guangdong Medical University, Guangdong, China.  \n2Nanchang University, Nanchang, China. 3Department of Breast Surgery, Affiliated Hospital of Guangdong Medical University, Guangdong, China. 4Department of Breast Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. 5Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China. 6Cancer Stem Cell and Translational Medicine Laboratory, Shengjing Hospital of China Medical University, Shenyang, China. 7These authors contributed equally: Xing Huang,Yuanyan Tang and Zhongzeng Liang.  \n􀀍 email: [Lzr0926@sina.com](Lzr0926@sina.com)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \nSecondary lymphedema significantly impairs patients’ quality of life, leading to substantial physical discomfort and psychological distress1,2. Conservative treatments for lymphedema include compression therapy and limb elevation, while surgical options include procedures such as lymph node transfer surgery, and lymphaticovenous anastomosis (LVA)3–5. The main objective of LVA is not only to restore lymphatic fluid drainage in the affected area but also to re-establish physiological lymphatic circulation, thereby optimizing the residual lymphatic function to the greatest extent possible6. LVA has been proven to be an effective treatment for ","cbCaik9Vkwz2anf9","https://ap.wps.com/l/cbCaik9Vkwz2anf9","pdf",2531104,11,"English","# Background and clinical need\n# Imaging modalities for lymphatic vessels\n# Study aim and methods\n## Patient cohort and localization groups\n## Comparison metrics (localization and diameter)\n# Results and comparative findings\n## CEUS vs UHFUS vs combined CEUS+UHFUS\n# Interpretation and clinical implications\n# Abbreviations","[{\"question\":\"What clinical problem does the study address in LVA planning?\",\"answer\":\"Successful LVA requires preoperative identification of functional lymphatic vessels and accurate measurement of their internal diameters; current single imaging approaches struggle to localize functional LVs and measure diameters accurately at the same time.\"},{\"question\":\"How were patients grouped in the retrospective study?\",\"answer\":\"Twenty-four female patients with secondary extremity lymphedema underwent three localization methods: CEUS combined with UHFUS (Group A), CEUS alone (Group B), and UHFUS alone (Group C).\"},{\"question\":\"What is the main finding about the combined CEUS+UHFUS approach?\",\"answer\":\"The combined approach rapidly located more functional LVs and also measured LV internal diameters more accurately than either CEUS alone or UHFUS alone, improving procedural efficiency.\"}]","Application of contrast-enhanced ultrasound combined with ultrahigh-frequency ultrasound in lymphaticovenous anastomosis | PDF",1790758980,28]