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This case report and literature review emphasizes early diagnosis and appropriate management to improve outcomes. A 65-year-old female underwent successful surgery and remained disease-free at one-year follow-up. The review summarizes clinical presentation, histopathology, pathogenesis, treatment options, and prognosis of ASRCC.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/appendiceal-signet-ring-cell-carcinoma-an-atypical-cause-of-acute-appendicitis-a-case-study-and-review-of-current-knowledge/378051/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/appendiceal-signet-ring-cell-carcinoma-an-atypical-cause-of-acute-appendicitis-a-case-study-and-review-of-current-knowledge/378051.png","ImageObject",300,407,{"name":92,"@type":93},"Alex Sinclair","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why can appendiceal signet ring cell carcinoma be mistaken for acute appendicitis?","Question",{"text":112,"@type":113},"ASRCC often presents with nonspecific symptoms that overlap with acute appendicitis, such as right lower abdominal pain. As a result, it is frequently unsuspected before surgery.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What histopathological feature defines appendiceal signet ring cell carcinoma?",{"text":117,"@type":113},"ASRCC is characterized by malignant cells containing large intracytoplasmic mucin vacuoles that displace the nucleus to the periphery, creating a signet ring appearance.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the purpose of this case report and literature review?",{"text":121,"@type":113},"The report aims to raise clinician awareness that ASRCC of the appendix can cause acute appendicitis, especially in atypical presentations or unexpected pathology. It also summarizes current knowledge on presentation, histopathology, pathogenesis, treatment, and prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},378051,1790436174,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","diagnostics  \nCase Report  \nAppendiceal Signet Ring Cell Carcinoma: An Atypical Cause of Acute Appendicitis—A Case Study and Review of Current Knowledge  \nBranko Andjelkovic 1,†, Bojan Stojanovic 1,2,†, Milica Dimitrijevic Stojanovic 3,*, Bojan Milosevic 1,2, Aleksandar Cvetkovic 1,2, Marko Spasic 1,2, Stefan Jakovljevic 1,2, Danijela Cvetkovic 4, Bojana S. Stojanovic 5, Danijela Milosev 3, Minja Mitrovic 6 and Vesna Stankovic 3  \nCitation: Andjelkovic, B.; Stojanovic, B.; Stojanovic, M.D.; Milosevic, B.; Cvetkovic, A.; Spasic, M.; Jakovljevic, S.; Cvetkovic, D.; Stojanovic, B.S.; Milosev, D.; et al. Appendiceal Signet Ring Cell Carcinoma: An Atypical Cause of Acute Appendicitis—A Case Study and Review of Current Knowledge. Diagnostics 2023, 13, 2359. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)diagnostics13142359  \nAcademic Editor: Paolo Aseni  \nReceived: 31 May 2023  \nRevised: 4 July 2023  \nAccepted: 6 July 2023  \nPublished: 13 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of General Surgery, University Clinical Center Kragujevac, 34000 Kragujevac, Serbia; [br.andjelkovic1990@gmail.com](br.andjelkovic1990@gmail.com) (B.A.); [bojan.stojanovic01@gmail.com](bojan.stojanovic01@gmail.com) (B.S.); [drbojanzm@gmail.com](drbojanzm@gmail.com) (B.M.); [draleksandarcvetkovic@gmail.com](draleksandarcvetkovic@gmail.com) (A.C.); [drmspasic@gmail.com](drmspasic@gmail.com) (M.S.); [stefan_jakov87@yahoo.com](stefan_jakov87@yahoo.com) (S.J.)  \n2 Department of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia  \n3 Department of Pathology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia; [danijelamilosevkg@gmail.com](danijelamilosevkg@gmail.com) (D.M.); [wesna.stankovic@gmail.com](wesna.stankovic@gmail.com) (V.S.)  \n4 Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia; [c_danijela@yahoo.com](c_danijela@yahoo.com)  \n5 Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac,  \n34000 Kragujevac, Serbia; [bojana.stojanovic04@gmail.com](bojana.stojanovic04@gmail.com)  \n6 Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia; [minjam034@gmail.com](minjam034@gmail.com)  \n* [Correspondence: milicadimitrijevic@yahoo.com](Correspondence: milicadimitrijevic@yahoo.com)  \n† These authors have contributed equally to this work.  \nAbstract: Appendiceal signet ring cell carcinoma (ASRCC) is a rare and aggressive form of appendiceal cancer, often presenting with nonspecific symptoms that overlap with acute appendicitis. Early diagnosis and appropriate management are crucial for improving patient outcomes in these rare malignancies. This case report and literature review aims to raise awareness among clinicians about ASRCC of the appendix as a cause of acute appendicitis and highlight the importance of considering this diagnosis in patients with atypical presentations or unexpected histopathological findings. We present a 65-year-old female patient with ASRCC who underwent successful surgical treatment and remains disease-free at the one-year follow-up. It also highlights the necessity of early detection and appropriate treatment in order to improve patient outcomes. In addition, a comprehensive literature review is provided, discussing the clinical presentation, histopathological characteristics, potential pathogenesis, treatment options, and prognosis of ASRCC.  \nKeywords: signet ring cell carcinoma; appendix; acute appendicitis; appendectomy; case report; literature review  \n1. Introduction  \nP","cbCairUX8QC5wh2Y","https://ap.wps.com/l/cbCairUX8QC5wh2Y","pdf",1159676,12,"English","# Introduction\n## Case Presentation\n## Discussion\n## Literature Review\n## Conclusion","[{\"question\":\"Why can appendiceal signet ring cell carcinoma be mistaken for acute appendicitis?\",\"answer\":\"ASRCC often presents with nonspecific symptoms that overlap with acute appendicitis, such as right lower abdominal pain. As a result, it is frequently unsuspected before surgery.\"},{\"question\":\"What histopathological feature defines appendiceal signet ring cell carcinoma?\",\"answer\":\"ASRCC is characterized by malignant cells containing large intracytoplasmic mucin vacuoles that displace the nucleus to the periphery, creating a signet ring appearance.\"},{\"question\":\"What is the purpose of this case report and literature review?\",\"answer\":\"The report aims to raise clinician awareness that ASRCC of the appendix can cause acute appendicitis, especially in atypical presentations or unexpected pathology. It also summarizes current knowledge on presentation, histopathology, pathogenesis, treatment, and prognosis.\"}]","Appendiceal Signet Ring Cell Carcinoma: An Atypical Cause of Acute Appendicitis - A Case Study and Review of Current Knowledge | PDF",1790228198]