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The study measured demographics, clinical presentations, surgical approaches, pathology findings, complications graded by Clavien-Dindo, and recurrence. Among 1110 patients, 25 had ANs; 72% were low-grade appendiceal mucinous neoplasms. Local recurrence occurred in 8%, while survival at 5 years was 88% overall and 80% disease-free. Conclusions emphasize the increasing incidence, diagnostic value of resected appendix pathology, and a higher LAMN prevalence, with limitations including single-institution retrospective design and small sample size.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/appendiceal-neoplasms-in-saudi-arabia-prevalence-and-clinicopathological-profile/339884/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/appendiceal-neoplasms-in-saudi-arabia-prevalence-and-clinicopathological-profile/339884.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main objective of this study?","Question",{"text":113,"@type":114},"To evaluate the prevalence and clinicopathological characteristics of appendiceal neoplasms in the authors’ institution in Saudi Arabia and compare findings with limited existing regional studies.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patients selected and what was the follow-up approach?",{"text":118,"@type":114},"All patients who had appendectomy with the appendix submitted for histopathological evaluation between May 2015 and June 2020 were included, enabling follow-up of 5 years or more at the time of data collection.",{"name":120,"@type":111,"acceptedAnswer":121},"What proportion of the diagnosed appendiceal neoplasms were low-grade appendiceal mucinous neoplasms (LAMNs)?",{"text":122,"@type":114},"Histopathology showed that 72% of the appendiceal neoplasms were low-grade appendiceal mucinous neoplasms.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},339884,1790100710,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","original article  \nAppendiceal neoplasms in Saudi Arabia: prevalence and clinicopathological profile  \nMohammed Nabil AlAli,ab Ahmad Zubaidi,a Thamer A. Bin Traiki,a Khayal Alkhayal,a Mohammed Sbaih,b Saud Khalid Aldeghaither,b Farah F. Almugrin,c Sulaiman Abdullah Alshammari,a Mohammed Alswayyed,d Maha Abdullaha  \nFrom the aColorectal Research Chair, Department of Surgery, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia; bDepartment of Surgery, Prince Mohammed bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia; cCollege of Medicine, Imam Mohammad ibn Saud Islamic University, Riyadh, Saudi Arabia; dDepartment of Pathology and Laboratory Medicine, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia  \nCorrespondence: Dr. Mohammed Nabil AlAli ∙ Department of Surgery, Prince Mohammed bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia ∙ drmo7ammed2@ [gmail.com](gmail.com) ORCID: 0000-0001-9011- 7357  \nCitation: AlAli MN, Zubaidi A, Bin Traiki TA, Alkhayal K, Sbaih M, Aldeghaither SK, et al. Appendiceal neoplasms in Saudi Arabia: prevalence and clinicopathological profile. Ann Saudi Med 2024; 44(4): 255-263. DOI: 10.5144/0256-4947 .2024.255  \nReceived: _March 3, 2024  \nAccepted: May 31, 2024  \nPublished: August 1, 2024  \nCopyright: Copyright © 2024, Annals of Saudi Medicine, Saudi Arabia. This is an open access article under the Creative Commons Attribution-NonCommercialNoDerivatives 4.0 International License (CC BY-NC-ND) . The details of which can be accessed at [http://](http://)[ ](http://)[creativecommons. org/licenses/by](creativecommons. org/licenses/by)nc-nd/4.0/  \nFunding: Deanship of Scientific Research, King Saud University, for funding through the Vice Deanship of Scientific Research Chairs, Research Chair of Colorectal Surgery  \nBACKGROUND: The appendix is a small organ with no particular known function. Primary appendiceal neoplasms (ANs) are rare. While the prevalence is increasing worldwide over the past two decades, no apparent increase in the prevalence of ANs has been reported in the Arabian Gulf States. Recently, a significant decline in the age at diagnosis of some types of ANs has been reported worldwide, with a female predominance.  \nOBJECTIVES: Evaluate the prevalence and clinicopathological characteristics of ANs within our institution in Saudi Arabia and compare them to limited existing studies from different regions as well as the Arabian Gulf States.  \nDESIGN: Retrospective cohort  \nSETTING: Tertiary care center in Riyadh  \nPATIENTS AND METHODS: All patients who underwent appendectomy and had the appendix submitted for histopathological evaluation between May 2015 and June 2020 were included to allow for a followup of 5 years or more at the time of data collection.  \nMAIN OUTCOME MEASURES: Demographics, clinical presentations, surgical interventions, histopathological findings, complications, and recurrence rates.  \nSAMPLE SIZE: 25 AN patients  \nRESULTS: Of 1110 patients, 25 had ANs (13 female and 12 male participants) with a mean (standard deviation) age of 54.6 (14.1) years. Only 40% presented with acute appendicitis, 64% had comorbidities, and less than 50% underwent laparoscopic appendectomy. Histopathologically, 72% were low-grade appendiceal mucinous neoplasms (LAMNs) . Complications were minimal grades (Clavien-Dindo classification), with 80% experiencing none. The mean hospital stay was 9.96 days. Local recurrence occurred in 8% of cases, and distant metastasis was documented in one adenocarcinoma case. However, the 5-year overall and disease-free survival rates were 88% and 80%, respectively. CONCLUSIONS: The incidence ofANs is increasing in Saudi Arabia with the higher prevalence of LAMNs. The pathological examination of theresected appendix played a pivotal role in the diagnosis of ANs. LIMITATIONS: Data collected retrospectively, a single institution, anda small populatio","cbCaijwaJ7xHDu9y","https://ap.wps.com/l/cbCaijwaJ7xHDu9y","pdf",256889,"English","# Background\n# Objectives\n# Design\n# Setting\n# Patients and Methods\n## Main Outcome Measures\n## Sample Size\n# Results\n# Conclusions\n# Limitations\n# Conflict of Interest","[{\"question\":\"What was the main objective of this study?\",\"answer\":\"To evaluate the prevalence and clinicopathological characteristics of appendiceal neoplasms in the authors’ institution in Saudi Arabia and compare findings with limited existing regional studies.\"},{\"question\":\"How were patients selected and what was the follow-up approach?\",\"answer\":\"All patients who had appendectomy with the appendix submitted for histopathological evaluation between May 2015 and June 2020 were included, enabling follow-up of 5 years or more at the time of data collection.\"},{\"question\":\"What proportion of the diagnosed appendiceal neoplasms were low-grade appendiceal mucinous neoplasms (LAMNs)?\",\"answer\":\"Histopathology showed that 72% of the appendiceal neoplasms were low-grade appendiceal mucinous neoplasms.\"}]","Appendiceal neoplasms in Saudi Arabia: prevalence and clinicopathological profile | PDF",1790032927,23]