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A historical review is provided to clarify how concepts and histopathological definitions shifted toward current criteria. A systematic review assesses how pathological classifications incorporated new findings from clinical and pathological research. The PSOGI and AJCC 8th edition systems are evaluated for prognostic grouping relevance.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/appendiceal-mucinous-neoplasms-from-clinic-to-pathology-and-prognosis/383791/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/appendiceal-mucinous-neoplasms-from-clinic-to-pathology-and-prognosis/383791.png","ImageObject",300,407,{"name":92,"@type":93},"Kyle","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why do appendiceal mucinous neoplasms classifications cause confusion across studies?","Question",{"text":112,"@type":113},"Classifications have changed over time, leading to differences in histopathological definitions and difficulty comparing results between research groups.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the historical focus of the review?",{"text":117,"@type":113},"It reviews how different classification systems for appendiceal mucinous tumors evolved and how new clinical and pathological research criteria were incorporated.",{"name":119,"@type":110,"acceptedAnswer":120},"How did the authors evaluate the PSOGI and AJCC 8th edition systems?",{"text":121,"@type":113},"They reclassified a treated patient series using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, then compared how well both systems matched OS and DFS, noting an advantage for PSOGI in histopathological description.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383791,1790719827,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","cancers   \nReview  \nAppendiceal Mucinous Neoplasms: From Clinic to Pathology and Prognosis  \nLuis Gonz¡lez Bayân 1,2, *,†, Lorena Mart½n Rom¡n 1,2, *,† and Pablo Lozano Lominchar 1,2  \nCitation: González Bayón, L.; Martín Román, L.; Lominchar, P.L.  \nAppendiceal Mucinous Neoplasms: From Clinic to Pathology and Prognosis. Cancers 2023, 15, 3426 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15133426  \nAcademic Editor: Marc Pocard  \nReceived: 19 April 2023  \nRevised: 20 June 2023  \nAccepted: 26 June 2023  \nPublished: 30 June 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Peritoneal Carcinomatosis Unit, Department of General Surgery, Hospital General Universitario Gregorio Marañân, 28007 Madrid, Spain; [pablo.lozano@salud.madrid.org](pablo.lozano@salud.madrid.org)  \n2 Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain  \n* Correspondence: [lgbayon@salud.madrid.org](lgbayon@salud.madrid.org) (L.G.B.); [lore_metro@hotmail.com](lore_metro@hotmail.com) (L.M.R.); Tel.: +34-6-3061-2308 (L.G.B.)  \n† These authors contributed equally to this work and are co-first authors.  \nSimple Summary: The cecal appendix is known to the general population because it is where acute appendicitis develops and it usually needs a surgical intervention for treatment. However, it is also the place of origin of tumors with special behavior. Those tumors are uncommon and generatespecific clinical situations, such as the mucocele or the pseudomyxoma peritonei syndrome, which are the subject of much debate regarding definitions and pathologic classification. There is great interest in achieving a common language for these tumors that will allow the sharing of research and treatment results which will improve the existing information and management of our patients.  \nAbstract: Appendiceal mucinous neoplasms have been classified differently over time causing confusion when comparing results between working groups in this field and establishing a prognosis of the disease. A historical perspective of the different classification systems of these tumors is essential for the understanding of the evolution of concepts and histopathological definitions that have led up to the present moment. We carried out a systematic review of the pathological classifications of appendiceal mucinous tumors and how they have included the new criteria resulting from clinical and pathological research. The latest classifications by PSOGI and AJCC 8th edition Cancer Staging have made a great effort to incorporate the new pathological descriptions and develop prognostic groups. The introduction of these new classification systems has posed the challenge of verifying how they adapt to our casuistry and which one defines best the prognosis of our patients. We reclassified our series of patients treated for mucinous appendiceal tumors with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy following the PSOGI and the AJCC 8th edition criteria and concluded that both classifications correspond well with the OS and DFS of these patients, with some advantage relative to the PSOGI classification due to a better histopathological description of the different groups.  \nKeywords: mucocele; pseudomyxoma peritoneal; mucinous appendiceal neoplasm; cytoreductive surgery; HIPEC; acellular mucina  \n1. Introduction  \nThe cecal appendix is a remnant organ with an unknown function in humans. It does not exist in carnivorous or herbivorous animals but it does in omnivores. The mucosa of the appendix has a colonic-type columnar epithelium with neuroendocrine cells and mucinproducing goblet cells. The submucosa is rich in lymp","cbCaidXe51OewDm4","https://ap.wps.com/l/cbCaidXe51OewDm4","pdf",1565475,24,"English","# Introduction\n# Definitions and clinical context\n## Mucocele of the appendix\n## Pseudomyxoma peritonei (PMP)\n# Pathological classification and prognostic impact","[{\"question\":\"Why do appendiceal mucinous neoplasms classifications cause confusion across studies?\",\"answer\":\"Classifications have changed over time, leading to differences in histopathological definitions and difficulty comparing results between research groups.\"},{\"question\":\"What is the historical focus of the review?\",\"answer\":\"It reviews how different classification systems for appendiceal mucinous tumors evolved and how new clinical and pathological research criteria were incorporated.\"},{\"question\":\"How did the authors evaluate the PSOGI and AJCC 8th edition systems?\",\"answer\":\"They reclassified a treated patient series using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, then compared how well both systems matched OS and DFS, noting an advantage for PSOGI in histopathological description.\"}]","Appendiceal Mucinous Neoplasms: From Clinic to Pathology and Prognosis | PDF",1790259274]