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The questions also ask students to analyze experimental effects of siRNAs targeting SR versus Sec62 and to connect protein-coding nucleotide lengths to differences in amino-acid counts. 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Outlines, bulleted lists, or diagrams alone are not acceptable unless the question specifically allows a diagram to supplement the discussion.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What control-related reasoning is expected for the experiments in the figures?",{"text":117,"@type":113},"Students must justify why researchers measured both Sec62 and SR relative amounts using cells treated with Sec62 siRNA only, as shown in Figure 1.",{"name":119,"@type":110,"acceptedAnswer":120},"How do students calculate the amino-acid difference from nucleotide lengths?",{"text":121,"@type":113},"Assuming all nucleotides encode amino acids, students convert nucleotide counts to amino-acid counts and compute the difference between the two proteins’ lengths.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},311306,1790028145,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":19,"category_name":20,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","2025  \nAP® Biology  \nFree-Response Questions  \n© 2025 College Board. College Board, Advanced Placement, AP, AP Central, and the acorn logo are registered trademarks [of College Board. Visit College Board on the web: collegeboard.org](of College Board. Visit College Board on the web: collegeboard.org).  \nAP Central is the official online home for [the AP Program: apcentral.collegeboard.org](the AP Program: apcentral.collegeboard.org).  \nBIOLOGY  \nSECTION II  \nTIME – 1 HOUR AND 30 MINUTES  \nDirections:  \nSection II has 6 questions and lasts 1 hour and 30 minutes.  \nRead each question carefully and completely. Answers must be written out in paragraph form. Outlines, bulleted lists, or diagrams alone are not acceptable. Do not spend time restating the questions or providing more than the number of examples called for. For instance, if a question calls for 2 examples, you can earn credit only for the first 2 examples that you provide. Labeled diagrams may be used to supplement discussion, but unless specifically called for by the question, a diagram alone will not receive credit.  \nYou may use the available paper for scratch work and planning, but you must write your answers in the free-response booklet. Label parts (e.g., A, B, C) and sub-parts (e.g., i, ii, iii) as needed. Use a pencil or a pen with black or dark blue ink to write your responses.  \nA calculator is allowed in this section. You may use a handheld calculator that is approved for this exam or the calculator available in this application. Reference information, including equations and formulas, is available in this application and can be accessed throughout the exam.  \nYou may pace yourself as you answer the questions in this section, or you may use these optional timing recommendations:  \nQuestions 1 and 2 are long free-response questions, and it is suggested that you spend about 25 minutes on each. Questions 3 through 6 are short free-response questions, and it is suggested that you spend about 10 minutes on each.  \nYou can go back and forth between questions in this section until time expires. The clock will turn red when 5 minutes remain—the proctor will not give you any time updates or warnings.  \nNote: This exam was originally administered digitally. It is presented here in a format optimized for teacher and student use in the classroom.  \nDuring the AP Exam administration, students have access to reference information. To see the reference information for this course, please visit AP Central:  \n[https://apcentral.collegeboard.org/courses/ap-biology/exam](https://apcentral.collegeboard.org/courses/ap-biology/exam)  \n© 2025 College Board.  \n[Visit College Board on the web:](Visit College Board on the web: collegeboard.org 2)[ collegeboard.org](Visit College Board on the web: collegeboard.org 2)[ 2](Visit College Board on the web: collegeboard.org 2)  \nAP BIOLOGY 2025 n FREE-RESPONSE QUESTIONS  \n1. Most proteins that are secreted from a cell must be transported to the endoplasmic reticulum (ER) either during translation or after translation.  \nA. Describe the function of ribosomes.  \nFor proteins transported during translation, this process begins in the cytosol and pauses when a specific sequence of amino acids is translated. The translation complex is then transported to the surface ofthe ER where translation continues. Proteins that are transported after translation are translated entirely in the cytosol and then transported to the ER. In both instances, the translated proteins enter the ER through a protein channel in the membrane of the ER.  \nResearchers studying the two types of protein transport identified that the ER membrane protein SR is necessary for transport during translation, while the ER membrane protein Sec62 is necessary for transport after translation. To investigate which transport mechanism is used for different proteins, researchers first created small interfering RNAs (siRNAs) that reduce expression of either SR or Sec62. They then treated g","cbCaihYqQ1JwiojX","https://ap.wps.com/l/cbCaihYqQ1JwiojX","pdf",513452,11,"English","# Time - 1 Hour and 30 Minutes\n# Directions\n## Answer format requirements\n## Allowed tools and reference information\n# Section II Questions\n## Question 1 (A-D)","[{\"question\":\"What format must AP Biology Section II answers follow?\",\"answer\":\"Answers must be written in paragraph form. Outlines, bulleted lists, or diagrams alone are not acceptable unless the question specifically allows a diagram to supplement the discussion.\"},{\"question\":\"What control-related reasoning is expected for the experiments in the figures?\",\"answer\":\"Students must justify why researchers measured both Sec62 and SR relative amounts using cells treated with Sec62 siRNA only, as shown in Figure 1.\"},{\"question\":\"How do students calculate the amino-acid difference from nucleotide lengths?\",\"answer\":\"Assuming all nucleotides encode amino acids, students convert nucleotide counts to amino-acid counts and compute the difference between the two proteins’ lengths.\"}]","AP Biology - Section II - Free-Response Questions | PDF",1789894114,28]