[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-383653-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-383653-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","antitumor-effects-of-dietary-compounds","Antitumor Effects of Dietary Compounds","","Cancer causes millions of deaths worldwide and current therapies such as chemotherapy, radiotherapy, immunotherapy, and surgery often lead to severe adverse effects and reduced effectiveness due to drug resistance. Plant-derived bioactive compounds are described as promising alternatives, with evidence that dietary molecules can induce ferroptosis, alter lipid peroxidation, generate ROS, suppress key signaling pathways, and trigger apoptosis. The article also highlights polysaccharides and glycosides, while noting gaps in data on bioavailability and pharmacokinetics.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/antitumor-effects-of-dietary-compounds/383653/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/antitumor-effects-of-dietary-compounds/383653.png","ImageObject",300,407,{"name":42,"@type":43},"River Wang","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are alternative cancer therapies needed beyond conventional chemotherapy?","Question",{"text":63,"@type":64},"Conventional treatments can cause severe side effects and can become ineffective due to cancer cells developing resistance to chemotherapeutic agents.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What mechanism is highlighted for Punicic acid against cancer cells?",{"text":68,"@type":64},"Punicic acid can induce ferroptosis in carcinoma cells, including both alone and in combination with docosahexaenoic acid, accompanied by increased lipid peroxidation.",{"name":70,"@type":61,"acceptedAnswer":71},"What research gap is noted for polysaccharide and dietary compound studies?",{"text":72,"@type":64},"The article states that studies lack data on bioavailability and pharmacokinetics, limiting translation to practical therapy.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},383653,1791101183,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":30,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":111},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","nutrients   \nEditorial  \nAntitumor Effects of Dietary Compounds  \nZeeshan Ahmad Bhutta   \nCitation: Bhutta, Z.A.; Choi, K.-C. Antitumor Effects of Dietary Compounds. Nutrients 2023, 15, 2349 .  \n[https://doi.org/10.3390/nu15102349](https://doi.org/10.3390/nu15102349)  \nReceived: 15 May 2023  \nAccepted: 16 May 2023  \nPublished: 17 May 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nand Kyung-Chul Choi *  \nLaboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea; [doctorzeeshan94@gmail.com](doctorzeeshan94@gmail.com)  \n* Correspondence: [kchoi@cbu.ac.kr](kchoi@cbu.ac.kr)  \nCancer is reported to be a major cause of death worldwide, accounting for 10 million in 2020 based on 19.3 million reported cases [1] . Currently, cancer treatment relies on chemotherapy, endotherapy, immunotherapy, radiotherapy, and surgical interventions depending on the type of cancer. Despite the treatment options mentioned above, which aid significantly in extending the lifespan of individuals, they result in unbearable side effects such as alopecia, anemia, dementia, nausea, peripheral neuropathy, etc. Furthermore, these traditional chemotherapeutic regimens are becoming nugatory against cancer cells because of the development of resistance to chemotherapeutic agents in cancers. Therefore, there is a dire need to search for alternatives to these traditional chemotherapeutic agents. Plants have been used to treat all kinds of illnesses for centuries. The oldest written  \nevidence of the use of plants as medicines, found on a Sumerian clay slab that contains recipes for different plants such as mandrake, henbane, and poppy as drugs, was found in the city of Nagpur, India, dating back 5000 years ago [2] . With the advancement of technology, bioactive compounds isolated from plants are now being used as therapeutic agents against a wide range of diseases, including cancer. It is estimated that more than 50% of the anti-cancer drugs currently being used in chemotherapy are derived from natural sources such as taxanes and their analogs, camptothecin and its derivates, vincristine, vinblastine, etc. [3] . Simply put, natural bioactive compounds are and will be a source of novel chemotherapeutic drugs used to treat various carcinomas.  \nA study published in this Special Issue highlights the role of Punicic acid (PunA), a type of conjugated linolenic acid (CLnA), obtained from various plant seed oils against the human colorectal HCT-116 and hypopharyngeal FaDu cancer cell lines. PunA was able to cause ferroptosis in carcinoma cells both alone and in combination with docosahexaenoic acid (DHA), a known anti-cancerous polyunsaturated fatty acid. This study also demonstrated a rise in lipid peroxidation in HCT-116 and FaDu carcinoma cells after PunA treatment [4] . Although chemicals present in plants are reported to be effective against many cancers, several studies have reported that a combination of different compounds is a better choice of method to stop cancer growth and metastasis. A recent study evaluated the efficacy of phenethyl isothiocyanate (PEITC), indole-3-carbinol (I3C), xanthohumol (X), and resveratrol (RES) against hepatocellular carcinoma (HCC) . This study proved that combination therapy was an effective approach that resulted in ROS generation by NQO1 . Moreover, COX-2 expression was suppressed in HepG2 cells treated with X and PEITC, while suppression in NF-􀀔B was recorded through the Nrf2 signaling pathway. All of this leads to the start of apoptosis in HepG2 cells [5] .  \nCorso et al. [6] reviewed the effects of different polysaccharides against breast","cbCailukJq7TIVVi","https://ap.wps.com/l/cbCailukJq7TIVVi","pdf",187484,"English","# Antitumor Effects of Dietary Compounds\n## Background: cancer burden and limitations of current therapies\n## Plant-derived bioactive compounds as alternatives\n## Evidence from dietary acids, phytochemicals, polysaccharides, and glycosides\n## Summary and remaining research needs","[{\"question\":\"Why are alternative cancer therapies needed beyond conventional chemotherapy?\",\"answer\":\"Conventional treatments can cause severe side effects and can become ineffective due to cancer cells developing resistance to chemotherapeutic agents.\"},{\"question\":\"What mechanism is highlighted for Punicic acid against cancer cells?\",\"answer\":\"Punicic acid can induce ferroptosis in carcinoma cells, including both alone and in combination with docosahexaenoic acid, accompanied by increased lipid peroxidation.\"},{\"question\":\"What research gap is noted for polysaccharide and dietary compound studies?\",\"answer\":\"The article states that studies lack data on bioavailability and pharmacokinetics, limiting translation to practical therapy.\"}]","Antitumor Effects of Dietary Compounds | PDF",1790258576]