[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-542800-105":59,"doc-detail-542800-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","antioxidant-treatment-and-the-chance-to-conceive-in-men-seeking-fertility-care-the-summer-randomized-clinical-trial","Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care - The SUMMER Randomized Clinical Trial","","Treatments for men seeking fertility care are limited, and antioxidant supplements have shown conflicting evidence regarding benefits. This multicenter, double-blind, placebo-controlled randomized clinical trial (21 Dutch hospitals/clinics) assessed whether the antioxidant supplement Impryl improves semen quality and pregnancy outcomes versus placebo. Among 1171 men, ongoing pregnancy within 6 months showed no significant between-group difference, and no secondary outcomes differed significantly. The investigators therefore do not support the supplement for improving pregnancy rates.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/antioxidant-treatment-and-the-chance-to-conceive-in-men-seeking-fertility-care-the-summer-randomized-clinical-trial/542800/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/antioxidant-treatment-and-the-chance-to-conceive-in-men-seeking-fertility-care-the-summer-randomized-clinical-trial/542800.png","ImageObject",300,407,{"name":92,"@type":93},"Jacob","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-10-11",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main question of the SUMMER trial?","Question",{"text":112,"@type":113},"Whether men seeking fertility care treated with an antioxidant supplement could improve semen quality and pregnancy rates compared with placebo.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the antioxidant supplement administered?",{"text":117,"@type":113},"Participants took Impryl daily for 6 months; the placebo tablet was identical in packaging and content appearance.",{"name":119,"@type":110,"acceptedAnswer":120},"Did the antioxidant supplement improve ongoing pregnancy rates?",{"text":121,"@type":113},"No. Ongoing pregnancy within 6 months was not significantly different between the antioxidant and placebo groups, and the investigators did not support its use for improving pregnancy rates.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},542800,1792122288,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962084931830,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Original Investigation | Urology  \nAntioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care The SUMMER Randomized Clinical Trial  \nWiep R. de Ligny, MD; Jan Peter de Bruin, PhD; Roos M. Smits, PhD; Ilse G. F. Goovaerts, PhD; Kris Peeters, PhD; Annemiek W. Nap, PhD; Jolanda C. Boxmeer, PhD; Rogier B. Donker, PhD; Marieke Schoonenberg, MD; CarolienA. M. Koks, PhD; Minouche M. E. van Rumste, PhD; Jantien Visser, PhD; Susanne C. J. P. Gielen, PhD; Carolien M. Boomsma, PhD; Jesper M. J. Smeenk, PhD; Robbert H. F. van Oppenraaij, PhD; Tessa Cox, MD; Femi Janse, PhD; Linda T. Muller, MD;  \nJanneke J. Brink-van der Vlugt, MSc; Didi D. M. Braat, PhD; Kathrin Fleischer, PhD  \nAbstract  \nIMPORTANCE Treatments for men seeking fertility care are limited. Antioxidant supplements have been widely studied as a new treatment option, but these studies have had conflicting results.  \nOBJECTIVE To assess whether treatment of men seeking fertility care with an antioxidant supplement can improve semen quality and pregnancy rates compared with a placebo.  \nDESIGN, SETTING, AND PARTICIPANTS The SUMMER trial was a multicenter, double-blind, placebo-controlled randomized clinical trial conducted in 21 hospitals and private fertility clinics in the Netherlands. Male patients in these centers were enrolled between May 2018 and February 2024, and follow-up of the primary outcome was completed in December 2024. Eligible participants were men aged 18 to 50 years with female partners aged 18 to 43 years, who sought fertility care and were advised to undergo expectant management, treatment with intrauterine insemination, in vitro fertilization (IVF), or intracytoplasmic sperm injection (ICSI) . Couples treated with ovulation induction only or IVF for bilateral tubal pathology were excluded. The men were randomly assigned to receive an antioxidant supplement or a placebo. Intention-to-treat analysis was performed for all outcomes.  \nINTERVENTIONS The antioxidant supplement (Impryl) was a tablet to be taken daily for 6 months. It contained betaine (200 mg), L-cystine (200 mg), niacin (16 mg), zinc (10 mg), vitamin B6 (1.4 mg), vitamin B2 (1.4 mg), folic acid (400 μg), and vitamin B12 (2.5 μg). The placebo tablet and its packaging were identical to those of the antioxidant supplement. All participating couples received standard infertility care.  \nMAIN OUTCOMESAND MEASURES The primary outcome was ongoing pregnancy conceived within 6 months after randomization. Secondary outcomes included semen parameters, sperm DNA fragmentation, fertilization and embryo utilization rates after IVF or ICSI, biochemical and clinical pregnancy rates, first-trimester pregnancy loss, ectopic pregnancy rate, cumulative number of pregnancies, time to pregnancy, and adverse events.  \nRESULTS A total of 1171 men (median [IQR] age, 34 [31-38] years; female partners’ median [IQR] age, 32 [30-35] years) were included in the data analysis, of whom 591 were in the antioxidant supplement group and 580 were in the placebo group. Ongoing pregnancy rate within 6 months was not significantly different between the 2 groups (193 of 571 [33.8%] vs 208 of 555 [37.5%]; adjusted odds ratio [AOR], 0.85 [95% CI, 0.66-1.09]; P = .20) . Within the window of optimal treatment effect between 4 and 6 months (considering a spermatogenesis cycle of 72 days), ongoing pregnancy rate  \n(continued)  \nKey Points  \nQuestion What is the effect of an antioxidant supplement on male fertility?  \nFindings In this randomized clinical trial including 1171 men seeking fertility care, the ongoing pregnancy rate achieved in men treated with the antioxidant supplement compared with men treated with a placebo was not significantly different.  \nMeaning In this trial, treatment of these patients using the antioxidant supplement did not improve pregnancy rates in their female partners.  \n+ Visual Abstract  \n+ Supplemental content  \nAuthor affiliations and article information are listed at the end of this artic","cbCaijkQnB5SOisS","https://ap.wps.com/l/cbCaijkQnB5SOisS","pdf",1035403,14,"English","# Key Points\n## Question\n## Findings\n## Meaning\n# Abstract\n## Importance\n## Objective\n## Design, Setting, and Participants\n## Interventions\n## Main Outcomes and Measures\n## Results\n## Conclusions and Relevance\n## Trial Registration\n# Introduction","[{\"question\":\"What was the main question of the SUMMER trial?\",\"answer\":\"Whether men seeking fertility care treated with an antioxidant supplement could improve semen quality and pregnancy rates compared with placebo.\"},{\"question\":\"How was the antioxidant supplement administered?\",\"answer\":\"Participants took Impryl daily for 6 months; the placebo tablet was identical in packaging and content appearance.\"},{\"question\":\"Did the antioxidant supplement improve ongoing pregnancy rates?\",\"answer\":\"No. Ongoing pregnancy within 6 months was not significantly different between the antioxidant and placebo groups, and the investigators did not support its use for improving pregnancy rates.\"}]","Antioxidant Treatment and the Chance to Conceive in Men Seeking Fertility Care - The SUMMER Randomized Clinical Trial | PDF",1791755136,35]