[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-441893-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-441893-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","antioxidant-enhanced-nanoparticles-delay-the-progression-of-osteoarthritis","Antioxidant-Enhanced Nanoparticles Delay the Progression of Osteoarthritis","","Osteoarthritis (OA) is an age-related degenerative disease in which oxidative stress (OS) drives mitochondrial dysfunction and inflammatory signaling. A mesoporous nanoparticle delivery platform (PCMg) was constructed from Mg2+, citric acid, and dopamine, then surface-loaded with the positively charged peptide SS31 to form PCMS. PCMS was rapidly internalized by chondrocytes and targeted to mitochondria, lowering ROS and restoring mitochondrial dysfunction in TBHP-mediated injury models. In vitro and DMM in vivo studies showed no malignant effects and a degradable profile, while histological stains indicated effective alleviation of OA progression, supporting PCMS as a strategy to delay OA development.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/antioxidant-enhanced-nanoparticles-delay-the-progression-of-osteoarthritis/441893/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/antioxidant-enhanced-nanoparticles-delay-the-progression-of-osteoarthritis/441893.png","ImageObject",300,407,{"name":42,"@type":43},"Đào","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-09","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main therapeutic goal of PCMS in osteoarthritis?","Question",{"text":63,"@type":64},"PCMS aims to reduce oxidative stress and ROS, thereby mitigating mitochondrial dysfunction and slowing OA progression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the PCMS nanoparticle platform constructed?",{"text":68,"@type":64},"PCMS was prepared by forming mesoporous nanoparticles (PCMg) from Mg2+, citric acid, and dopamine, then adsorbing the positively charged peptide SS31 onto the surface via charge interaction.",{"name":70,"@type":61,"acceptedAnswer":71},"What evidence supports PCMS effectiveness against OA?",{"text":72,"@type":64},"In vitro assays showed reduced ROS and restored mitochondrial function in chondrocytes under TBHP challenge, while the DMM OA model with multiple histological stains demonstrated alleviated OA progression. Both in vivo and in vitro results indicated no malignant effects on chondrocyte viability and proliferation and that the material was degradable.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},441893,1790894182,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":124,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","This article is licensed under CC-BY-NC-ND 4.0   \n[http://pubs.acs.org/journal/acsodf](http://pubs.acs.org/journal/acsodf)  Article   \nAntioxidant-Enhanced Nanoparticles Delay the Progression of Osteoarthritis  \nChengchun Shen,\\# Jiapei Yu,\\# Haibin Xiang, Jinti Lin, Kaipeng Jin, Bing Liu, * and Huimin Tao*  \n Cite This: ACS Omega 2025, 10, 59034−59043  \nRead Online  \n\n|  |  |  |  |  |  |\n| --- | --- | --- | --- | --- | --- |\n| ACCESS   | Metrics & More |  |  Article Recommendations |  | *sı Supporting Information |\n\nABSTRACT: Osteoarthritis (OA) is an age-related degenerative disease. Oxidative stress (OS) regulates the pathogenesis of OA by affecting mitochondrial function. Mg2+ and citric acid can delay the progression of OA through reducing OS, but integrated therapy. In this study, amesoporous nanoparticle (PCMg) composed of Mg2+, citric acid (CC), and dopamine was developed as a novel delivery platform. SS31, a positively charged peptide, was adsorbed onto the surface of PCMg through the charge interaction to obtain the new nanoparticle platform (PCMS). SS31 endowed PCMS with good biocompatibility and enabled it to be rapidly endocytosed by chondrocytes and simultaneously localized in mitochondria. In vitro, PCMS effectively reduced the reactive oxygen species (ROS) level and restored mitochondrial dysfunction mediated by tert-butyl hydroperoxide (TBHP) through reducing OS in chondrocytes. In addition, both in vivo and in vitro results demonstrated that PCMS had no malignant effect on chondrocyte viability and proliferation and was degradable. Through the destabilization of the medial meniscus (DMM) OA model, hematoxylin−eosin (HE), safranin, fast green (SO), and toluidine blue (TB) staining indicated that PCMS effectively alleviated the progression of OA. Comprehensive analysis indicated that PCMS treatment was an effective strategy for alleviating the progression of OA.  \n1. INTRODUCTION  \nOsteoarthritis (OA) is a chronic, degenerative cartilage disorder primarily characterized by joint pain, dysfunction, and significant movement impairment, representing a leading cause of disability. Currently, over 300 million individuals worldwide are affected by OA, which places a substantial economic burden on societies. With an aging population, projections indicate that nearly 25% of adults will be afflicted by OA by 2030.1,2 Despite their high prevalence and disability rate, effective treatment options remain scarce. For advanced cases, surgery is often the only viable option, while no therapies exist to reverse or significantly slow the disease in its early stages.  \nOA pathology is typically characterized by cartilage degeneration, osteophyte formation, and persistent inflammatory responses. 1−3 While the precise pathogenic mechanisms remain unclear, oxidative stress (OS)-driven inflammation is recognized as a key factor in the initiation and progression of the disease. Cartilage consists primarily of chondrocytes and extracellular matrix (ECM), with chondrocytes synthesizing ECM components that in turn provide a supportive environment for the cells. This feedback loop maintains cartilage metabolic homeostasis. However, in early OA, altered joint biomechanics and OS-induced inflammation disrupt this equilibrium, reducing the expression ofkey ECM components, such as collagen and aggrecan. Concurrently, inflammatory mediators, including IL-1, TNF-α, and matrix metalloprotei-  \nnases such as MMP13, are released, triggering an inflammatory cascade that accelerates OA progression. Consequently, targeting OS offers a promising therapeutic approach to delay OA progression.4−8  \nGiven the multifaceted factors contributing to arthritis progression and the growing evidence supporting the use of molecules from natural sources in its treatment, leveraging bioactive molecules from natural sources presents a promising therapeutic approach.9−11 Molecules from natural sources serve as invaluable resources for discovering novel pharmacologica","cbCaieczGEjWs3cW","https://ap.wps.com/l/cbCaieczGEjWs3cW","pdf",8776700,"English","# ABSTRACT\n# 1. INTRODUCTION\n## Epidemiology and treatment limitations of OA\n## OS-driven inflammation and cartilage homeostasis disruption\n## Natural molecules and citric acid as therapeutic candidates\n## Polydopamine/mesoporous PDA as drug-delivery and ROS-scavenging materials","[{\"question\":\"What is the main therapeutic goal of PCMS in osteoarthritis?\",\"answer\":\"PCMS aims to reduce oxidative stress and ROS, thereby mitigating mitochondrial dysfunction and slowing OA progression.\"},{\"question\":\"How was the PCMS nanoparticle platform constructed?\",\"answer\":\"PCMS was prepared by forming mesoporous nanoparticles (PCMg) from Mg2+, citric acid, and dopamine, then adsorbing the positively charged peptide SS31 onto the surface via charge interaction.\"},{\"question\":\"What evidence supports PCMS effectiveness against OA?\",\"answer\":\"In vitro assays showed reduced ROS and restored mitochondrial function in chondrocytes under TBHP challenge, while the DMM OA model with multiple histological stains demonstrated alleviated OA progression. Both in vivo and in vitro results indicated no malignant effects on chondrocyte viability and proliferation and that the material was degradable.\"}]","Antioxidant-Enhanced Nanoparticles Delay the Progression of Osteoarthritis | PDF",1790697995,25]