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It explains their mechanism of action as inhibiting norepinephrine in the peripheral nervous system (PNS) to treat benign prostatic hyperplasia (BPH) and hypertension (HTN), and decreasing central nervous system (CNS) activity for HTN. The document outlines the reasons for administration, including certain cardiac arrhythmias, BPH, and HTN. Adverse effects are comprehensively listed, covering EENT (dry eyes), CV (AV block, bradycardia, hypotension, palpitations), GI (dry mouth, constipation, nausea, vomiting), GU (erectile dysfunction), Derm (rash, sweating), F&E (sodium retention, hyperkalemia), Metab (weight gain), Neuro (paresthesia), and withdrawal phenomena. Nursing considerations emphasize monitoring intake and output ratios, daily weight, assessing for edema, and monitoring blood pressure and pulse. It advises slow titration for patients with cardiac conditions or those on other sympatholytic drugs and reporting significant changes. Specific instructions are provided for transdermal application, including proper application and that the system can remain during bathing or swimming. The document also lists significant drug interactions, such as with adrenergic drugs (risk of HTN), levodopa (hypotension, decreased levodopa effect), anesthetic agents (increased anesthetic effect), beta blockers (hypertension), lithium (lithium toxicity), haloperidol (psychotic behavior), and contraindications or precautions for central action with hepatic disease and MAOI antidepressant therapy, and for peripheral action with ulcerative colitis and peptic ulcers.",{"@graph":69,"@context":99},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/antihypertensives-adrenergic-blocking-drugs-alpha-beta-central-and-peripherally-acting/27282",{"url":83,"name":65,"@type":85,"author":86,"headline":65,"publisher":89,"fileFormat":92,"description":67,"dateModified":93,"datePublished":93,"encodingFormat":92,"isAccessibleForFree":94,"interactionStatistic":95},"DigitalDocument",{"name":87,"@type":88},"Jiven","Person",{"url":74,"name":90,"@type":91},"DocShare","Organization","application/pdf","2026-05-08",true,{"@type":96,"interactionType":97,"userInteractionCount":4},"InteractionCounter",{"@type":98},"ViewAction","https://schema.org",{"og:url":83,"og:type":101,"og:title":65,"og:site_name":90,"og:description":67},"article",{"robots":103,"canonical":83},"index,follow",{"doc_id":105,"site_id":62},27282,1778274628,{"code":4,"msg":5,"data":108},{"doc_id":105,"user_id":109,"nickname":87,"user_avatar":110,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":111,"file_url":112,"file_type":113,"file_size":114,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":115,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":116,"seo_description":67,"update_tm":106,"read_time":81},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","cbCaipwF0pkhPVRO","https://ap.wps.com/l/cbCaipwF0pkhPVRO","pdf",587632,"English","Antihypertensives Adrenergic Blocking Drugs Alpha Beta Central and Peripherally Acting | PDF"]