[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-27440-en":3,"doc-seo-27440-105":27,"detail-sidebar-cat-0-en-105":69},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":20,"language":21,"language_code":22,"site_id":23,"html_lang":22,"table_of_contents":15,"faqs":15,"seo_title":24,"seo_description":14,"update_tm":25,"read_time":26},27440,687197100911,"Himbo","https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697",7,"Healthcare","Antihypertensives Ace Inhibitors","This document provides a comprehensive overview of ACE inhibitors, a class of antihypertensive medications. It details their mechanism of action, explaining how they suppress the renin-angiotensin-aldosterone system to prevent the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This inhibition leads to reduced sodium and water retention, thereby decreasing blood pressure. The document outlines the primary indications for ACE inhibitor use, including the treatment of hypertension and heart failure, emphasizing the importance of frequent blood pressure and pulse monitoring. It also highlights crucial assessments for patients, such as monitoring for signs of angioedema and fluid overload in heart failure cases. Potential adverse effects are meticulously listed, covering cardiovascular, central nervous system, gastrointestinal, genitourinary, dermatological, fluid and electrolyte imbalances, and respiratory systems. Specific concerns like hyperkalemia, orthostatic hypotension, and coughe are mentioned. The document also addresses contraindications and precautions, particularly for heart failure patients, those with salt or volume depletion, bilateral renal artery stenosis, angioedema history, and pregnant individuals in the second or third trimester due to the risk of neonatal death. Drug interactions are detailed, including NSAIDs, rifampin, allopurinol, digoxin, loop diuretics, lithium, hypoglycemics, and potassium-sparing diuretics, with explanations of their effects on ACE inhibitors or vice versa. Finally, it offers nursing insights, advising to be mindful of medication suffixes (ending in 'pril') and to use caution with the African American population, as ACE inhibitors may be less effective or cause distinct side effects.","","cbCaivJzaNI7BxMr","https://ap.wps.com/l/cbCaivJzaNI7BxMr","pdf",602038,1,"English","en",105,"Antihypertensives Ace Inhibitors | PDF",1778275066,3,{"code":4,"msg":28,"data":29},"ok",{"site_id":23,"language":22,"slug":30,"title":13,"keywords":15,"description":14,"schema_data":31,"social_meta":64,"head_meta":66,"extra_data":68,"updated_unix":25},"antihypertensives-ace-inhibitors",{"@graph":32,"@context":63},[33,49],{"@type":34,"itemListElement":35},"BreadcrumbList",[36,40,44,46],{"item":37,"name":38,"@type":39,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":41,"name":42,"@type":39,"position":43},"https://docshare.wps.com/document/","Document",2,{"item":45,"name":12,"@type":39,"position":26},"https://docshare.wps.com/document/healthcare/",{"item":47,"name":13,"@type":39,"position":48},"https://docshare.wps.com/document/antihypertensives-ace-inhibitors/27440",4,{"url":47,"name":13,"@type":50,"author":51,"headline":13,"publisher":53,"fileFormat":56,"description":14,"dateModified":57,"datePublished":57,"encodingFormat":56,"isAccessibleForFree":58,"interactionStatistic":59},"DigitalDocument",{"name":9,"@type":52},"Person",{"url":37,"name":54,"@type":55},"DocShare","Organization","application/pdf","2026-05-08",true,{"@type":60,"interactionType":61,"userInteractionCount":4},"InteractionCounter",{"@type":62},"ViewAction","https://schema.org",{"og:url":47,"og:type":65,"og:title":13,"og:site_name":54,"og:description":14},"article",{"robots":67,"canonical":47},"index,follow",{"doc_id":7,"site_id":23},{"code":4,"msg":5,"data":70},[71,75,79,83,88,93,96,101,106,109,113],{"id":20,"doc_module":4,"doc_module_name":42,"category_name":72,"show_sort_weight":73,"slug":74},"Story & Novel",90,"story-novel",{"id":43,"doc_module":4,"doc_module_name":42,"category_name":76,"show_sort_weight":77,"slug":78},"Literature",80,"literature",{"id":48,"doc_module":4,"doc_module_name":42,"category_name":80,"show_sort_weight":81,"slug":82},"Exam",70,"exam",{"id":84,"doc_module":4,"doc_module_name":42,"category_name":85,"show_sort_weight":86,"slug":87},5,"Comic",60,"comic",{"id":89,"doc_module":4,"doc_module_name":42,"category_name":90,"show_sort_weight":91,"slug":92},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":42,"category_name":12,"show_sort_weight":94,"slug":95},40,"healthcare",{"id":97,"doc_module":4,"doc_module_name":42,"category_name":98,"show_sort_weight":99,"slug":100},8,"Research & Report",30,"research-report",{"id":102,"doc_module":4,"doc_module_name":42,"category_name":103,"show_sort_weight":104,"slug":105},9,"Religion & Spirituality",20,"religion-spirituality",{"id":104,"doc_module":4,"doc_module_name":42,"category_name":107,"show_sort_weight":104,"slug":108},"World Cup","world-cup",{"id":110,"doc_module":4,"doc_module_name":42,"category_name":111,"show_sort_weight":110,"slug":112},10,"Lifestyle","lifestyle",{"id":114,"doc_module":4,"doc_module_name":42,"category_name":115,"show_sort_weight":84,"slug":116},19,"General","general"]