[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436106-105":59,"doc-detail-436106-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","antihyperlipidemic-drugs-mitigate-the-elevated-incidence-of-peptic-ulcer-disease-caused-by-hyperlipidemia-a-cohort-study","Antihyperlipidemic drugs mitigate the elevated incidence of peptic ulcer disease caused by hyperlipidemia - A cohort study","","Several risk factors have been linked to peptic ulcer disease (PUD), yet recurrence remains high despite standard ulcer therapies. High cholesterol has been proposed as a contributor, but clinical confirmation is limited. A long-term cohort study using Taiwan’s National Health Insurance Research Database evaluated whether hyperlipidemia increases PUD risk and whether antihyperlipidemic treatments reduce it. Hyperlipidemia showed higher PUD incidence and antihyperlipidemic drugs were associated with reduced risk, with stronger dose-exposure signals than red yeast rice.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/antihyperlipidemic-drugs-mitigate-the-elevated-incidence-of-peptic-ulcer-disease-caused-by-hyperlipidemia-a-cohort-study/436106/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/antihyperlipidemic-drugs-mitigate-the-elevated-incidence-of-peptic-ulcer-disease-caused-by-hyperlipidemia-a-cohort-study/436106.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Does hyperlipidemia increase the incidence of peptic ulcer disease (PUD)?","Question",{"text":112,"@type":113},"Yes. The incidence of PUD was higher in the hyperlipidemia cohort than in the nonhyperlipidemia cohort (adjusted hazard ratio 1.48; 95% CI 1.46-1.50; p \u003C 0.001).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did antihyperlipidemic drugs affect PUD risk in patients with hyperlipidemia?",{"text":117,"@type":113},"Patients using antihyperlipidemic drugs had a lower risk of developing PUD compared with those who did not use them. The adjusted hazard ratios were 0.33 (95% CI 0.21-0.52) for antihyperlipidemic drugs with or without red yeast rice, and 0.81 (95% CI 0.78-0.84) for the related group reported in the results.",{"name":119,"@type":110,"acceptedAnswer":120},"Is the risk reduction related to cumulative exposure, and does it apply to red yeast rice?",{"text":121,"@type":113},"Increasing cumulative exposure to antihyperlipidemic drugs and red yeast rice showed a decreasing trend in PUD risk. The trend was statistically significant for antihyperlipidemic drugs but not for red yeast rice.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436106,1791129169,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","J Chin MedAssoc  \nOriginal article  \nAntihyperlipidemic drugs mitigate the elevated incidence of peptic ulcer disease caused by hyperlipidemia: A cohort study  \nPei-Hsien Chena, Chiu-Lin Tsaib, Yow-Wen Hsiehc,d, Der-Yang Choe,f,g, Fuu-Jen Tsaih,i,j,k, Cheng-Li Linl, Hsien-Yin Liaom,n,*  \naDepartment of Chinese Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC; bDepartment of Chinese Medicine Pharmacy, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC; cDepartment of Pharmacy, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC; dGraduate Institute of Pharmacy, China Medical University, Taichung, Taiwan, ROC; e Translational Cell Therapy Center, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC; fDepartment of Neurosurgery, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC; gGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC; hSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC; iDepartment of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC; jDivision of Medical Genetics, China Medical University Children’s Hospital, China Medical University, Taichung, Taiwan, ROC; kDepartment of Medical Laboratory Science & Biotechnology, Asia University, Taichung, Taiwan, ROC; lManagement Office for Health Data, China Medical University Hospital, Taichung, China Medical University, Taiwan, ROC; mSchool of Post-Baccalaureate Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC; nDepartment of Acupuncture, China Medical University Hospital, China Medical University, Taichung, Taiwan, ROC  \nAbstract  \nBackground: Several risk factors for peptic ulcer disease (PUD) have been identified; however, the recurrence rate of PUD remains high even with standard ulcer treatments. High cholesterol levels have been proposed as a risk factor for PUD, but clinical evidence remains limited. Therefore, this database study investigated whether hyperlipidemia increases PUD risk and whether antihyperlipidemic drugs reduce this risk.  \nMethods: A long-term cohort design was adopted, and Taiwan’s National Health Insurance Research Database was used to enroll patients diagnosed with hyperlipidemia between 2000 and 2016. Patients without hyperlipidemia were randomly matched based on variables such as age and gender to establish a comparison cohort at a 1:1 ratio. Another cohort study was conducted to determine whether antihyperlipidemic drugs or red yeast rice prescriptions can reduce the incidence of PUD in patients with hyperlipidemia.  \nResults: The overall incidence of PUD was 1.48 times higher in the hyperlipidemia cohort (203,235 patients) than in the nonhyperlipidemia cohort (adjusted hazard ratio, 1.48; 95% CI, 1.46-1.50; p \u003C 0.001) . Among the patients with hyperlipidemia, those who used antihyperlipidemic drugs with or without red yeast rice prescriptions exhibited a lower risk of developing PUD relative to those who did not use them; the adjusted hazard ratios were 0.33 (95% CI, 0.21-0.52) and 0.81 (95% CI, 0.78-0.84), respectively. When the cumulative exposure to antihyperlipidemic drugs and red yeast rice prescriptions increased, the risk of developing PUD showed a decreasing trend, which was statistically significant for antihyperlipidemic drugs but not for red yeast rice.  \nConclusion: Hyperlipidemia is associated with a higher risk of PUD, which can be reduced through the administration of antihyperlipidemic drugs with or without red yeast rice prescriptions.  \nKeywords: Chinese medicine; Hyperlipidemia; National Health Insurance Research Database; Red yeast rice  \n*Address correspondence. Dr. Hsien-Yin Liao, School of Post-Baccalaureate Chinese Medicine, College of ","cbCaimwN32aGk0NY","https://ap.wps.com/l/cbCaimwN32aGk0NY","pdf",567952,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"Does hyperlipidemia increase the incidence of peptic ulcer disease (PUD)?\",\"answer\":\"Yes. The incidence of PUD was higher in the hyperlipidemia cohort than in the nonhyperlipidemia cohort (adjusted hazard ratio 1.48; 95% CI 1.46-1.50; p \\u003c 0.001).\"},{\"question\":\"How did antihyperlipidemic drugs affect PUD risk in patients with hyperlipidemia?\",\"answer\":\"Patients using antihyperlipidemic drugs had a lower risk of developing PUD compared with those who did not use them. The adjusted hazard ratios were 0.33 (95% CI 0.21-0.52) for antihyperlipidemic drugs with or without red yeast rice, and 0.81 (95% CI 0.78-0.84) for the related group reported in the results.\"},{\"question\":\"Is the risk reduction related to cumulative exposure, and does it apply to red yeast rice?\",\"answer\":\"Increasing cumulative exposure to antihyperlipidemic drugs and red yeast rice showed a decreasing trend in PUD risk. The trend was statistically significant for antihyperlipidemic drugs but not for red yeast rice.\"}]","Antihyperlipidemic drugs mitigate the elevated incidence of peptic ulcer disease caused by hyperlipidemia - A cohort study | PDF",1790676812]