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The review outlines EF24’s rapid absorption, broad tissue distribution, and efficient metabolism that support bioavailability and sustained target-tissue exposure, including its ability to cross biological barriers and accumulate in tumors. It consolidates evidence of anticancer efficacy across breast, lung, prostate, colon, and pancreatic cancers, and explains how EF24 modulates NF-κB and Nrf2 signaling to reduce pro-tumor inflammation and oxidative stress, promoting apoptosis and cell-cycle arrest. The work also covers mechanisms involving NF-κB inhibition, microRNA regulation, and proteasomal pathways, and discusses nanoformulation strategies for improved drug delivery, while emphasizing solubility and stability challenges requiring further 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Action, and Nanoformulation for Drug Delivery  \nIliyana Sazdova 1, Milena Keremidarska-Markova 1, Daniela Dimitrova 2, Vadim Mitrokhin 3, Andre Kamkin 3, Nikola Hadzi-Petrushev 4, Jane Bogdanov 5, Rudolf Schubert 6, Hristo Gagov 1, Dimiter Avtanski 7, *,† and Mitko Mladenov 3,4, *,†  \nCitation: Sazdova, I.; KeremidarskaMarkova, M.; Dimitrova, D.; Mitrokhin, V.; Kamkin, A.; HadziPetrushev, N.; Bogdanov, J.; Schubert, R.; Gagov, H.; Avtanski, D.; et al.  \nAnticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery. Cancers 2023, 15, 5478. [https://](https://)[ ](https://)[doi.org/10.3390/cancers15225478](doi.org/10.3390/cancers15225478)  \nAcademic Editor: Lingzhi Wang  \nReceived: 8 October 2023  \nRevised: 10 November 2023  \nAccepted: 14 November 2023  \nPublished: 20 November 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Animal and Human Physiology, Faculty of Biology, Sofia University `St. Kliment Ohridski', 1504 Sofia, Bulgaria; i.sazdova@biofac.uni-sofi[a.bg](a.bg) (I.S.); m_keremidarska@uni-sofi[a.bg](a.bg) (M.K.-M.); hgagov@uni-sofi[a.bg](a.bg) (H.G.)  \n2 Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria; [daniadim@yahoo.com](daniadim@yahoo.com)  \n3 Department of Fundamental and Applied Physiology, Russian States Medical University,  \n117997 Moscow, Russia; [mitrokhin_vm@rsmu.ru](mitrokhin_vm@rsmu.ru) (V.M.); [andrey.kamkin@rsmu.ru](andrey.kamkin@rsmu.ru) (A.K.)  \n4 Institute of Biology, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, 1000 Skopje, North Macedonia; [nikola@pmf.ukim.mk](nikola@pmf.ukim.mk)  \n5 Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, 1000 Skopje, North Macedonia; [jane.bogdanov@pmf.ukim.mk](jane.bogdanov@pmf.ukim.mk)  \n6 Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, Universitätsstrasse 2, 86159 Augsburg, Germany; [rudolf.schubert@med.uni-augsburg.de](rudolf.schubert@med.uni-augsburg.de)  \n7 Friedman Diabetes Institute, Lenox Hill Hospital, Northwell Health, 110 E 59th Street, New York, NY 10022, USA  \n* Correspondence: [davtanski@northwell.edu](davtanski@northwell.edu) (D.A.); [mitkom@pmf.ukim.mk](mitkom@pmf.ukim.mk) (M.M.)† These authors contributed equally to this work.  \nSimple Summary: This study summarizes the current state of knowledge about the anticancer potential of the curcumin analog EF24, including its pharmacokinetic profile, therapeutic efficacy, underlying mechanisms, and advancements in nanoformulations for effective drug delivery. EF24 and its nanoformulations hold great promise as novel and effective therapeutic strategies for cancer treatment and provide hope for patients to fight this devastating disease. More preclinical and clinical investigations are needed to fully unlock their potential and integrate them into clinical practice.  \nAbstract: EF24, a synthetic monocarbonyl analog of curcumin, shows significant potential as an anticancer agent with both chemopreventive and chemotherapeutic properties. It exhibits rapid absorption, extensive tissue distribution, and efficient metabolism, ensuring optimal bioavailability and sustained exposure of the target tissues. The ability of EF24 to penetrate biological barriersand accumulate at tumor sites makes it advantageous for effective cancer treatment. Studies have demonstrated EF24's remarkable efficacy against various cancers, including breast, lung, pr","cbCainRK0yzWK6p4","https://ap.wps.com/l/cbCainRK0yzWK6p4","pdf",2894933,31,"English","# Introduction\n## Structurally Related Mechanisms of Action\n# Simple Summary","[{\"question\":\"What is EF24 and why is it considered anticancer?\",\"answer\":\"EF24 is a synthetic monocarbonyl analog of curcumin with chemopreventive and chemotherapeutic properties, showing significant anticancer potential.\"},{\"question\":\"How does EF24 work at the molecular level?\",\"answer\":\"EF24 modulates NF-κB and Nrf2 signaling, disrupting tumor-promoting inflammation and oxidative stress, and promotes tumor growth inhibition through mechanisms such as apoptosis and cell-cycle arrest.\"},{\"question\":\"What advantages do EF24 nanoformulations provide for drug delivery?\",\"answer\":\"Nanoformulations aim to improve effective delivery by enhancing how the drug reaches tumor sites, complementing EF24’s barrier penetration and accumulation, while addressing delivery-related limitations.\"}]","Anticarcinogenic Potency of EF24: An Overview of Its Pharmacokinetics, Efficacy, Mechanism of Action, and Nanoformulation for Drug Delivery | PDF",1790273979,78]