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Antimicrobial peptides (AMPs), with high efficacy and low toxicity, are considered promising candidates to complement or replace chemoradiotherapy. As innate-immune-derived small peptides, some AMPs selectively kill diverse cancer cells with reduced harm to normal cells. Their anti-cancer activity mainly relies on membrane destruction, offering advantages against drug-resistant tumors, while stability and hemolytic toxicity limit clinical translation; functionalized nanoparticles may address these barriers.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/anticancer-mechanisms-and-potential-anticancer-applications-of-antimicrobial-peptides-and-their-nano-agents-review/338881/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/anticancer-mechanisms-and-potential-anticancer-applications-of-antimicrobial-peptides-and-their-nano-agents-review/338881.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are antimicrobial peptides considered promising anticancer candidates?","Question",{"text":113,"@type":114},"They show high efficiency and low toxicity, can selectively kill broad cancer-cell populations, and may replace or complement chemoradiotherapy that often has limited tolerability and resistance issues.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What mechanism mainly drives the anticancer effects of antimicrobial peptides?",{"text":118,"@type":114},"Their anti-cancer actions mainly involve membrane destruction effects, including interactions with negatively charged cancer cell membranes and subsequent disruption leading to cancer cell death.",{"name":120,"@type":111,"acceptedAnswer":121},"How can nanoparticles help overcome the limitations of antimicrobial peptides?",{"text":122,"@type":114},"Functionalized nanoparticles provide strategies to improve issues such as poor peptide stability and hemolytic toxicity, supporting more effective anticancer application of AMPs.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},338881,1790138408,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","International Journal of Nanomedicine Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nAnticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents  \nZiyi Dong 1 , 2 , Xinyu Zhang 1 , Qing Zhang 1 , Jakkree Tangthianchaichana 1 , 3 , Mingxue Guo 1 , Shouying Du 1 , Yang Lu 1  \n1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand  \nCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email [luyang@bucm.edu.cn](luyang@bucm.edu.cn); dumenzidi [123@163.com](123@163.com)  \n\n| Abstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction.\u003Cbr>Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents |\n| --- |\n| Introduction\u003Cbr>Cancer, as one of the most lethal diseases in the world, is still a serious threat to human survival.1 Chemotherapy alone or combined with surgery/radiotherapy plays an important role in improving the life expectancy of cancer patients. However, due to the lack of specificity of many chemotherapeutic drugs for cancer cells, they can also kill healthy cells that are in rapid proliferation phase while killing cancer cells, which may lead to serious side effects.2,3 Additionally, cancer cells are prone to develop resistance to chemotherapeutic drugs resulting from drug inactivation or efflux, target protein alteration, DNA damage repair, and signaling cascade alteration, which greatly limits the efficacy of such drugs.4,5 Therefore, it is urgent to find new potent drugs with high tumor selectivity.\u003Cbr>In recent years, antimicrobial peptides (AMPs) have attracted the attention of researchers. AMPs are small-molecule peptides with positive charges and amphipathic properties.6 They are part of the innate immune defense system of organisms with multiple biological activities such as antibacterial activity, antifungal activity, anticancer activity, and immune system regulation.7,8 On the one hand, due to their positive charges and amphiphilic nature, AMPs can selectively bind to negatively charged cancer cell membranes through electrostatic attraction and forma transmembrane channel, destroying the integrity of the cell membrane, t","cbCairz5mM3udtxi","https://ap.wps.com/l/cbCairz5mM3udtxi","pdf",5065278,23,"English","# Abstract\n# Introduction\n# Anticancer mechanisms of antimicrobial peptides\n# Multidrug resistance and tumor selectivity","[{\"question\":\"Why are antimicrobial peptides considered promising anticancer candidates?\",\"answer\":\"They show high efficiency and low toxicity, can selectively kill broad cancer-cell populations, and may replace or complement chemoradiotherapy that often has limited tolerability and resistance issues.\"},{\"question\":\"What mechanism mainly drives the anticancer effects of antimicrobial peptides?\",\"answer\":\"Their anti-cancer actions mainly involve membrane destruction effects, including interactions with negatively charged cancer cell membranes and subsequent disruption leading to cancer cell death.\"},{\"question\":\"How can nanoparticles help overcome the limitations of antimicrobial peptides?\",\"answer\":\"Functionalized nanoparticles provide strategies to improve issues such as poor peptide stability and hemolytic toxicity, supporting more effective anticancer application of AMPs.\"}]","Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents - Review | PDF",1790026362,58]