[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-209213-en":3,"doc-seo-209213-105":31,"detail-sidebar-cat-0-en-105":96},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":28,"seo_description":14,"update_tm":29,"read_time":30},209213,1649267921044,"Ava Thompson","https://us-avatar.wpscdn.com/avatar/1800007509477c92dfb?_k=1786009248482753345",7,"Healthcare","Antibiotic Susceptibility Testing of Some Prevotella Strains Isolated from Vestibular Abscesses - Original Article","The study investigates in vitro antibiotic susceptibility of 53 Prevotella strains isolated from vestibular abscesses. Minimum inhibitory concentrations for benzylpenicillin, ampicillin, amoxicillin/clavulanic acid, clindamycin, and metronidazole were determined using E-test, and beta-lactamase production was assessed with a chromogenic cephalosporin test. Most strains were susceptible, but 12 were resistant to benzylpenicillin and ampicillin due to beta-lactamase production, and one P. buccae isolate showed clindamycin resistance. Findings support metronidazole or clindamycin, and advise beta-lactamase–active options when treatment is empirical.","ORIGINAL ARTICLE  \nANTIBIOTIC SUSCEPTIBILITY TESTING OF SOME PREVOTELLA STRAINS ISOLATED FROM VESTIBULAR ABSCESSES  \nADRIAN BĂNCESCU\\#, GABRIELA BĂNCESCU\\#*, ANDREEA DIDILESCU\\#, MIRCEA HÎRJĂU\\#“Carol Davila”University of Medicine and Pharmacy, Bucharest, Romania  \n*[corresponding author: gabi.bancescu@gmail.com](corresponding author: gabi.bancescu@gmail.com)  \n\\#All authors contributed equally to this study.  \nManuscript received: February2013  \nAbstract  \nThe aim of this study was to investigate in vitro the antibiotic susceptibility of 53 strains of Prevotella isolated from vestibular abscesses. The E-test was used for determining the minimum inhibitory concentrations for: benzylpenicillin, ampicillin, amoxicillin/clavulanic acid, clindamycin and metronidazole. In addition to this, the beta-lactamase production was detected by the chromogenic cephalosporin test. Most of the strains were susceptible to the tested antibiotics. Twelve strains were resistant to benzylpenicillin and ampicillin due to the production of beta-lactamase. A single isolate of P. buccae presented also resistance to clindamycin. In conclusion, the results of this study recommend the prescription of metronidazole or clindamycin in infections caused by these microorganisms. In case of oral and maxillofacial infections (which are mainly mixed infections), when antimicrobial treatment is necessary but it is done empirically, it might be proper to choose an antibiotic active against beta-lactamase producing bacteria too, such as an association of a penicillin with a beta-lactamase inhibitor.  \nRezumat  \nAcest studiu a avut drept scop investigarea in vitro a sensibilității la antibiotice a 53 de tulpini de Prevotella izolate dinabcese vestibulare. A fost utilizat E-test-ul pentru determinarea concentrațiilor minime inhibitorii pentru: benzilpenicilină, ampicilină, amoxicilină/acid clavulanic, clindamicină şi metronidazol. Pe lângă acest aspect, a fost detectată și producerea de beta-lactamază prin testul cu o cefalosporină cromogenă . Majoritatea tulpinilor au fost sensibile la toate cele 5 antibiotice. Un număr de 12 tulpini s-au dovedit a fi rezistente la benzilpenicilină şi ampicilină, datorită elaborării de beta-lactamază . Un singur izolat de P. buccae a prezentat concomitent șirezistență la clindamicină . În concluzie, rezultatele acestui studiu local recomandă utilizarea în infecțiile produse de aceste microorganisme a metronidazolului sau a clindamicinei. În cazul infecțiilor orale șimaxilo-faciale (ce sunt cu precădere infecții mixte), atunci când tratamentul antimicrobian se impune, însă este practicat empiric, ar fi adecvată alegerea unui antibiotic activ inclusiv pe bacteriile producătoare de beta-lactamază, precum asocierea unei peniciline cu un inhibitor de beta-lactamază .  \nKeywords: oral infections, Prevotella, antibiotic resistance  \nIntroduction  \nThe oral infections are mainly mixed infections, involving usually both aerobic and strictly anaerobicmicroorganisms, with the last ones predominating [15]. The most frequently anaerobic bacteria associated with infections of dental origin are represented by the Gram-negative bacilli, such as different species of Prevotella, Porphyromonas, Bacteroides, Tannerella and Fusobacterium. Most oral and maxillofacial abscesses require only surgical incision and drainage as treatment. However, the antibiotics are needed sometimes in order to prevent the local or distant spread of the infection, especially in immuno-compromised patients. Based partially on the fact that the anaerobic bacteria are usually fastidious and slowgrowing, many physicians consider the isolation and identification of the strictly anaerobes as time  \nconsuming and prefer to prescribe empirically the antibiotics in this type of infections.  \nPenicillin is still considered to be the antimicrobial agent of choice for the treatment of oral infections, but there are a lot of recent studies which reported penicillin resistant anaerobic str","cbCaisc0ThMtTYGc","https://ap.wps.com/l/cbCaisc0ThMtTYGc","pdf",248746,3,1,4,"English","en",105,"# Introduction\n# Materials and Methods\n# Results\n# Discussion\n# Conclusion","[{\"question\":\"What was the main goal of the study on Prevotella strains?\",\"answer\":\"To investigate in vitro antibiotic susceptibility of 53 Prevotella strains isolated from vestibular abscesses.\"},{\"question\":\"Which antibiotics and test methods were used?\",\"answer\":\"E-test was used to determine minimum inhibitory concentrations for benzylpenicillin, ampicillin, amoxicillin/clavulanic acid, clindamycin, and metronidazole; beta-lactamase production was detected using a chromogenic cephalosporin test.\"},{\"question\":\"Why were some strains resistant to benzylpenicillin and ampicillin?\",\"answer\":\"Twelve strains were resistant due to beta-lactamase production, as detected by the chromogenic cephalosporin test.\"}]","Antibiotic Susceptibility Testing of Some Prevotella Strains Isolated from Vestibular Abscesses - Original Article | PDF",1788610869,10,{"code":4,"msg":32,"data":33},"ok",{"site_id":25,"language":24,"slug":34,"title":13,"keywords":35,"description":14,"schema_data":36,"social_meta":91,"head_meta":93,"extra_data":95,"updated_unix":29},"antibiotic-susceptibility-testing-of-some-prevotella-strains-isolated-from-vestibular-abscesses-original-article","",{"@graph":37,"@context":90},[38,53,73],{"@type":39,"itemListElement":40},"BreadcrumbList",[41,45,49,51],{"item":42,"name":43,"@type":44,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":46,"name":47,"@type":44,"position":48},"https://docshare.wps.com/document/","Document",2,{"item":50,"name":12,"@type":44,"position":20},"https://docshare.wps.com/document/healthcare/",{"item":52,"name":13,"@type":44,"position":22},"https://docshare.wps.com/document/antibiotic-susceptibility-testing-of-some-prevotella-strains-isolated-from-vestibular-abscesses-original-article/209213/",{"url":52,"name":13,"@type":54,"image":55,"author":60,"headline":13,"publisher":62,"fileFormat":65,"inLanguage":24,"description":14,"dateModified":66,"datePublished":67,"encodingFormat":65,"isAccessibleForFree":68,"interactionStatistic":69},"DigitalDocument",{"url":56,"@type":57,"width":58,"height":59},"https://docshare.wps.com/thumbnails/antibiotic-susceptibility-testing-of-some-prevotella-strains-isolated-from-vestibular-abscesses-original-article/209213.png","ImageObject",300,407,{"name":9,"@type":61},"Person",{"url":42,"name":63,"@type":64},"DocShare","Organization","application/pdf","2026-09-11","2026-09-05",true,{"@type":70,"interactionType":71,"userInteractionCount":20},"InteractionCounter",{"@type":72},"ViewAction",{"@type":74,"mainEntity":75},"FAQPage",[76,82,86],{"name":77,"@type":78,"acceptedAnswer":79},"What was the main goal of the study on Prevotella strains?","Question",{"text":80,"@type":81},"To investigate in vitro antibiotic susceptibility of 53 Prevotella strains isolated from vestibular abscesses.","Answer",{"name":83,"@type":78,"acceptedAnswer":84},"Which antibiotics and test methods were used?",{"text":85,"@type":81},"E-test was used to determine minimum inhibitory concentrations for benzylpenicillin, ampicillin, amoxicillin/clavulanic acid, clindamycin, and metronidazole; beta-lactamase production was detected using a chromogenic cephalosporin test.",{"name":87,"@type":78,"acceptedAnswer":88},"Why were some strains resistant to benzylpenicillin and ampicillin?",{"text":89,"@type":81},"Twelve strains were resistant due to beta-lactamase production, as detected by the chromogenic cephalosporin test.","https://schema.org",{"og:url":52,"og:type":92,"og:title":13,"og:site_name":63,"og:description":14},"article",{"robots":94,"canonical":52},"index,follow",{"doc_id":7,"site_id":25},{"code":4,"msg":5,"data":97},[98,102,106,110,115,120,123,128,133,136,139],{"id":21,"doc_module":4,"doc_module_name":47,"category_name":99,"show_sort_weight":100,"slug":101},"Story & Novel",90,"story-novel",{"id":48,"doc_module":4,"doc_module_name":47,"category_name":103,"show_sort_weight":104,"slug":105},"Literature",80,"literature",{"id":22,"doc_module":4,"doc_module_name":47,"category_name":107,"show_sort_weight":108,"slug":109},"Exam",70,"exam",{"id":111,"doc_module":4,"doc_module_name":47,"category_name":112,"show_sort_weight":113,"slug":114},5,"Comic",60,"comic",{"id":116,"doc_module":4,"doc_module_name":47,"category_name":117,"show_sort_weight":118,"slug":119},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":47,"category_name":12,"show_sort_weight":121,"slug":122},40,"healthcare",{"id":124,"doc_module":4,"doc_module_name":47,"category_name":125,"show_sort_weight":126,"slug":127},8,"Research & Report",30,"research-report",{"id":129,"doc_module":4,"doc_module_name":47,"category_name":130,"show_sort_weight":131,"slug":132},9,"Religion & Spirituality",20,"religion-spirituality",{"id":131,"doc_module":4,"doc_module_name":47,"category_name":134,"show_sort_weight":131,"slug":135},"World Cup","world-cup",{"id":30,"doc_module":4,"doc_module_name":47,"category_name":137,"show_sort_weight":30,"slug":138},"Lifestyle","lifestyle",{"id":140,"doc_module":4,"doc_module_name":47,"category_name":141,"show_sort_weight":111,"slug":142},19,"General","general"]