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Although therapy has advanced, identifying molecular mechanisms remains essential. This study examined PON2, a multifunctional enzyme linked to antiapoptotic signaling, to clarify whether abnormal PON2 expression supports evasion of programmed cell death and contributes to treatment resistance. Patients with locally advanced disease were enrolled and tumor and normal tissues were analyzed using in silico expression analyses, differential expression, survival evaluation, and gene set enrichment. Elevated PON2 in advanced tumor stages correlated with tobacco exposure, higher grade, and nodal metastasis, while lower expression associated with improved survival. Pathway enrichment suggested PON2-influenced routes supporting metastasis, supporting PON2 as a prognostic biomarker for oral cancer management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/antiapoptotic-pon2-expression-and-its-clinical-implications-in-locally-advanced-oral-squamous-cell-carcinoma/336334/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/antiapoptotic-pon2-expression-and-its-clinical-implications-in-locally-advanced-oral-squamous-cell-carcinoma/336334.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why focus on PON2 in locally advanced oral squamous cell carcinoma?","Question",{"text":112,"@type":113},"PON2 is linked to antiapoptotic mechanisms, and aberrant expression in oral cancers may help tumors evade programmed cell death and develop treatment resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What analyses were used to evaluate PON2’s role?",{"text":117,"@type":113},"The study used in silico gene expression analysis, differential gene expression in the patient cohort, survival analysis, and gene set enrichment analysis on tumor and normal tissue data.",{"name":119,"@type":110,"acceptedAnswer":120},"What clinical associations and survival findings were reported for PON2?",{"text":121,"@type":113},"PON2 levels were higher in advanced tumor stages and correlated with tobacco exposure, higher tumor grade, and nodal metastasis. Survival analysis indicated prognostic relevance, with lower PON2 expression linked to extended survival.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},336334,1790099457,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Received: 29 January 2024 | Revised: 7 March 2024 | Accepted: 20 March 2024  \nDOI: 10. 1111/cas.16170  \nOR I G I NAL ART I C L E  \nAntiapoptotic PON2 expression and its clinical implications in locally advanced oral squamous cell carcinoma  \nMehta Vedant Kamal1  Sanjiban Chakrabarty3   \n| Rama Rao Damerla2  | Preetiparna Parida2 || Mahadev Rao4  | Naveena AN Kumar1   \n1Department of Surgical Oncology, Manipal Comprehensive Cancer Care Centre, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India 2Department of Medical Genetics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India  \n3 Department of Public Health and Genomics, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India 4Department of Pharmacy Practice, Centre for Translational Research, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India  \nCorrespondence  \nNaveena AN Kumar, Department of Surgical Oncology, Manipal Comprehensive Cancer Care Centre, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India. Email: [naveenkumar.an@manipal.edu](naveenkumar.an@manipal.edu)  \nFunding information  \nDepartment of Biotechnology, Government of India, Ramalingaswami Fellowship, Grant/Award Number: BT/ RLF/Re-entry/21/2018;  \nManipal Academy of Higher Education, Grant/Award Number: 00000676  \nAbstract  \nLocally advanced oral squamous cell carcinoma poses a significant challenge in oncology due to its rising incidence and mortality rates. Despite therapeutic progress, understanding molecular intricacies is essential. This study explored the role of PON2, a multifunctional enzyme implicated in antiapoptotic mechanisms. Aberrant PON2 expression in oral cancers raises questions regarding its involvement in evading programmed cell death and treatment resistance. Patients with locally advanced disease were enrolled, and molecular analyses were undertaken on the collected tumor and normal tissues. Utilizing computational datasets, this study used in silico gene expression analysis, differential gene expression analysis in our patient cohort, survival analysis, and gene set enrichment analysis to unravel role of PON2 in disease prognosis. The results showed elevated PON2 levels in advanced tumor stages, correlating with factors such as tobacco exposure, higher tumor grade, and nodal metastasis. Survival analysis revealed prognostic relevance of PON2, with lower expression linked to extended survival rates. Gene set enrichment analysis identified pathways aiding in cancer metastasis influenced by PON2. This study underscores the significance of PON2 expression as a prognostic marker for oral malignancies, with increased expression associated with advanced disease stages. Understanding the molecular profile of the PON2 gene suggests its potential as a valuable biomarker for the management of cancer.  \nK E Y WO R D S  \ndiagnosis by expression analysis, enzymes, metastasis-associated gene, oral cavity, prognostic marker  \nAbbreviations: ACTB, β-actin; cBioPortal, Cancer Genomics Portal; CI, confidence interval; DFS, disease-free survival; ENE, extranodal extension; GEPIA2, Gene Expression Profiling Interactive Analysis 2; GO, Gene Ontology; HIF-1α , hypoxia-inducible factor 1-alpha; HPV, human papillomavirus; IEC, Institutional Ethics Committee; KEGG, Kyoto Encyclopedia of Genes and Genomes; NF-κB, nuclear factor-kappa B; OS, overall survival; OSCC, oral squamous cell carcinoma; PON2, paraoxonase-2; TCGA-HNSCC, The Cancer Genome Atlas datasets for head and neck squamous cell carcinoma; TPM, transcripts per million.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifi","cbCairW8r3xTDxL1","https://ap.wps.com/l/cbCairW8r3xTDxL1","pdf",2558766,11,"English","# Abstract\n## Background and rationale\n## Study design and analyses\n## Key results and clinical implications\n## Keywords and abbreviations","[{\"question\":\"Why focus on PON2 in locally advanced oral squamous cell carcinoma?\",\"answer\":\"PON2 is linked to antiapoptotic mechanisms, and aberrant expression in oral cancers may help tumors evade programmed cell death and develop treatment resistance.\"},{\"question\":\"What analyses were used to evaluate PON2’s role?\",\"answer\":\"The study used in silico gene expression analysis, differential gene expression in the patient cohort, survival analysis, and gene set enrichment analysis on tumor and normal tissue data.\"},{\"question\":\"What clinical associations and survival findings were reported for PON2?\",\"answer\":\"PON2 levels were higher in advanced tumor stages and correlated with tobacco exposure, higher tumor grade, and nodal metastasis. Survival analysis indicated prognostic relevance, with lower PON2 expression linked to extended survival.\"}]","Antiapoptotic PON2 expression and its clinical implications in locally advanced oral squamous cell carcinoma | PDF",1790014562,28]