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This retrospective single-center case series evaluates whether treatment in photodamaged areas yields anti-aging changes in skin texture and solar lentigines.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/antiaging-effects-of-tirbanibulin-1-ointment-a-reallife-experience/328085/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/antiaging-effects-of-tirbanibulin-1-ointment-a-reallife-experience/328085.png","ImageObject",300,407,{"name":42,"@type":43},"Violet","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What 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[https://doi.org/10.1007/s13555-024-01178-0](https://doi.org/10.1007/s13555-024-01178-0)  \nCASE SERIES  \nAnti‑aging Effects of Tirbanibulin 1% Ointment: A Real‑Life Experience  \nFederica Li Pomi · Lucia Peterle · Andrea d’Aloja · Antonio Di Tano · Mario Vaccaro · Francesco Borgia  \nReceived: April 10, 2024 / Accepted: April 26, 2024 / Published online: May 14, 2024 © The Author(s) 2024  \nABSTRACT  \nIntroduction: Tirbanibulin 1% ointment has been licensed to treat non-hyperkeratotic actinic keratosis (AKs) on the face and scalp in adults to ensure excellent patient tolerability due to the mild side effects and the brief application time compared to other topical therapies on the market. A growing body of evidence suggests that, beyond their primary function, the treatments for AKs and the cancerization field may inadvertently confer substantial cosmetic benefits to patients.  \nF. Li Pomi  \nDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy  \ne-mail: [federicalipomi@hotmail.it](federicalipomi@hotmail.it)  \nL. Peterle · A. d’Aloja · A. Di Tano · M. Vaccaro ·  \nF. Borgia (*)  \nDepartment of Clinical and Experimental Medicine, Section of Dermatology, University of Messina, Messina, Italy  \ne-mail: [fborgia@unime.it](fborgia@unime.it)  \nL. Peterle  \ne-mail: [lucia.peterle@gmail.com](lucia.peterle@gmail.com)  \nA. d’Aloja  \ne-mail: [andredalo@hotmail.it](andredalo@hotmail.it)  \nA. Di Tano  \ne-mail: antonio_ditano@yahoo.it  \nM. Vaccaro  \n[e-mail: mario.vaccaro@unime.it](e-mail: mario.vaccaro@unime.it)  \nMethods: We report a single-center retrospective case series of patients referred to the Dermatology Unit of the University Hospital of Messina, Italy, between February and December 2023 seeking treatment for AKs in the context of photodamaged areas in which the application of tirbanibulin 1% ointment induced, besides clearance of AKs, anti-aging effects on both skin texture and solar lentigos.  \nResults: Seven patients affected by Olsen grade 1–2 AKs experienced a powerful rejuvenating effect in the treated areas, with a marked efficacy in skin lightening and clearance of solar lentigo.  \nConclusions: Tirbanibulin 1% ointment seems able to improve skin aging as a desirable side effect at the site of application for AKson chronic photodamaged skin. Such preliminary observation needs further confirmation in real-life studies on larger cohorts of patients, to explain the pathogenic mechanisms responsible for such aesthetically relevant results.  \nKeywords: Actinic keratosis; Anti-aging; Rejuvenation; Solar lentigo; Tirbanibulin; Tirbanibulin ointment; Wrinkle  \nKey Summary Points  \nTirbanibulin 1% ointment has been licensed to treat non-hyperkeratotic actinic keratosis (AKs) on the face and scalp in adults to ensure excellent patient tolerability due to the mild side effects and the brief application time.  \nTopical treatments for AKs may inadvertently confer cosmetic benefits to patients, but the anti-aging effects of tirbanibulin 1% ointment have not yet been reported.  \nWe report the first case series of patients seeking treatment for AKs in the context of photodamaged areas in which the application of tirbanibulin 1% ointment induced, besides clearance of AKs, anti-aging effects on both skin texture and solar lentigos.  \nThe stunning aspect of the observations in our study is the reduction of mottled pigmentation and skin lightening after treatment with tirbanibulin 1% ointment, data not observed in any other therapy for the treatment of AKs.  \nINTRODUCTION  \nActinic keratosis (AK) is a cutaneous intraepithelial neoplasm commonly arising in sunexposed areas among adults, particularly on the face, scalp, and dorsal hands of predisposed individuals over the age of 40 [1] . Risk factors include older age, male gender, Fitzpatrick skin types I–II, prolonged exposure to ultraviolet (UV) radiation, use of sunbeds, prol","cbCaitwtWGibSHQ0","https://ap.wps.com/l/cbCaitwtWGibSHQ0","pdf",1330029,14,"English","# Abstract\n## Introduction\n## Methods\n## Results\n## Conclusions\n# Keywords / Key Summary Points","[{\"question\":\"What is tirbanibulin 1% ointment used for in adults?\",\"answer\":\"It is licensed to treat non-hyperkeratotic actinic keratoses on the face and scalp in adults, with mild side effects and brief application time.\"},{\"question\":\"What patient outcome beyond AK clearance was reported?\",\"answer\":\"Patients showed anti-aging effects, including improvements in skin texture and lightening/clearance of solar lentigines at the treatment sites.\"},{\"question\":\"How was the case series conducted and when were patients treated?\",\"answer\":\"A single-center retrospective case series included patients referred between February and December 2023 at the Dermatology Unit of the University Hospital of Messina.\"}]","Anti‑aging Effects of Tirbanibulin 1% Ointment: A Real‑Life Experience | PDF",1789978620,35]