[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436195-105":59,"doc-detail-436195-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","anti-inflammatory-and-anticancer-effects-of-polysaccharides-from-antrodia-cinnamomea-a-review","Anti-inflammatory and anticancer effects of polysaccharides from Antrodia cinnamomea - A review","","Antrodia cinnamomea (Ac), a medicinal and food fungus used in Taiwan, contains polysaccharides (Ac-PS) that are promising adjunct candidates for cancer and inflammation. This review distinguishes general, non-sulfated Ac-GPS and sulfated Ac-SPS, highlighting immunomodulatory, anti-inflammatory, and anticancer actions via interleukin signaling modulation. Ac-GPS alleviates inflammation in brain and liver contexts, whereas Ac-SPS shows efficacy in macrophage models, with apoptosis-driven anticancer effects across cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/anti-inflammatory-and-anticancer-effects-of-polysaccharides-from-antrodia-cinnamomea-a-review/436195/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/anti-inflammatory-and-anticancer-effects-of-polysaccharides-from-antrodia-cinnamomea-a-review/436195.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are the two types of Antrodia cinnamomea polysaccharides discussed in the review?","Question",{"text":112,"@type":113},"The review distinguishes general, non-sulfated polysaccharides (Ac-GPS) and sulfated polysaccharides (Ac-SPS).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do Ac-GPS and Ac-SPS exert anti-inflammatory effects?",{"text":117,"@type":113},"Both are described as influencing interleukin signaling pathways to produce anti-inflammatory effects, with different efficacy contexts noted for Ac-GPS versus Ac-SPS.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence supports the anticancer effects of Ac-derived polysaccharides?",{"text":121,"@type":113},"The review states that in vitro and in vivo studies support anticancer effects, primarily by inducing apoptosis in multiple cancer cell lines, and may include synergy with chemotherapy and antiangiogenic properties.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436195,1790766340,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","J Chin MedAssoc  \nReview ARticle  \nAnti-inflammatory and anticancer effects of polysaccharides from Antrodia cinnamomea: A review  \nZhi-Hu Lina, Sang-Nguyen-Cao Phana,b, Diem-Ngoc-Hong Tranb, Mei-Kuang Lua,c,d, Tung-Yi Lina,c,d,e,*  \naInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; bFaculty of Traditional Medicine, University of Health Sciences, Vietnam National University, Ho Chi Minh, Vietnam; cSchool of Chinese Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; dTraditional Chinese Medicine Glycomics Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; eProgram in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei, Taiwan, ROC  \nAbstract  \nAntrodia cinnamomea (Ac), also known as “Niu-Chang-Chih” in Chinese, is a valuable fungus that has been widely used as medicine and food among indigenous people in Taiwan. Ac is rich in polysaccharides (Ac-PS), making it a promising candidate for adjunctive therapy in cancer and inflammation conditions. There are two types of Ac-PS: general (non-sulfated) PS (Ac-GPS) and sulfated PS (Ac-SPS) . This review highlights that both Ac-GPS and Ac-SPS possess immunomodulatory, anti-inflammatory, and anticancer properties. Each type influences interleukin signaling pathways to exert its anti-inflammatory effects. Ac-GPS is particularly effective in alleviating inflammation in the brain and liver, while Ac-SPS shows its efficacy in macrophage models. Both Ac-GSP and Ac-SPS have demonstrated anticancer effects supported by in vitro and in vivo studies, primarily through inducing apoptosis in various cancer cell lines. They may also synergize with chemotherapy and exhibit antiangiogenic properties. Notably, Ac-SPS appears to have superior anticancer efficacy, potentially due to its sulfate groups. Furthermore, Ac-SPS has been more extensively studied in terms of its mechanisms and effects on lung cancer compared with Ac-GPS, highlighting its significance in cancer research. In addition, Ac-SPS is often reported for its ability to activate macrophage-mediated responses. Clinically, AcGPS has been used as an adjunctive therapy for advanced lung cancer, as noted in recent reports. However, given the numerous studies emphasizing its anticancer mechanisms, Ac-SPS may exhibit greater efficacy, warranting further investigation. This review concludes that Ac-derived Ac-GPS orAc-SPS have the potential to be developed into functional health supplements or adjunctive therapies, providing dual benefits of anti-inflammatory and anticancer effects.  \nKeywords: Immunomodulation; Inflammation; Polysaccharides; Sulfated; Taiwan  \n[www.ejcma.org](www.ejcma.org) 1  \n\u003Cz10.1097/JCMA.0000000000001186>  \nLin et al. J Chin MedAssoc  \n1. INTRODUCTION  \nAntrodia cinnamomea (Ac), also known as Niu-chang-chih in Chinese, as well as red camphor mushroom, camphor mushroom, blood Ganoderma, and divine mushroom, is an edible indigenous fungus species in Taiwan. It belongs to the order Polyporales of the Polyporaceae family, and can be classified under the genus Taiwanofungus or Antrodia. The naming and classification of Ac have undergone several revisions; in 2010, the Dictionary of Fungi and MycoBank officially revised the name Niu-changchih to Taiwanofungus camphoratus, while also recognizing alternative names such as Ganoderma comphoratum, Antrodia camphorata, and Ac. Specifically, the Bioresource Collection and Research Center (BCRC) in Taiwan has confirmed Ac as the scientific name for this species.1 Ac grows on Cinnamomum trees and is typically found in forests at elevations between 400 and 2000 m above sea level. Owing to its slow growth rate, Ac is cultivated using two primary techniques: submerged fermentation and solidstate fermentation.2 These methods enable extensive cultivation to meet commercial demand.  \nNative Taiwanese have traditionally used Ac to alleviate fatigue-like symptoms.","cbCaihN04zLQOyLK","https://ap.wps.com/l/cbCaihN04zLQOyLK","pdf",3193613,11,"English","# Introduction\n## Anti-inflammatory properties of GPS and SPS derived from Ac\n### Role of GPS in anti-inflammatory responses","[{\"question\":\"What are the two types of Antrodia cinnamomea polysaccharides discussed in the review?\",\"answer\":\"The review distinguishes general, non-sulfated polysaccharides (Ac-GPS) and sulfated polysaccharides (Ac-SPS).\"},{\"question\":\"How do Ac-GPS and Ac-SPS exert anti-inflammatory effects?\",\"answer\":\"Both are described as influencing interleukin signaling pathways to produce anti-inflammatory effects, with different efficacy contexts noted for Ac-GPS versus Ac-SPS.\"},{\"question\":\"What evidence supports the anticancer effects of Ac-derived polysaccharides?\",\"answer\":\"The review states that in vitro and in vivo studies support anticancer effects, primarily by inducing apoptosis in multiple cancer cell lines, and may include synergy with chemotherapy and antiangiogenic properties.\"}]","Anti-inflammatory and anticancer effects of polysaccharides from Antrodia cinnamomea - A review | PDF",1790677107,28]