[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-386478-105":59,"doc-detail-386478-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","anti-cancer-properties-of-flaxseed-proteome-review","Anti-Cancer Properties of Flaxseed Proteome - Review","","Flaxseed is a recognized source of nutrients and bioactive compounds, including proteins that support multiple health benefits. Evidence shows that flaxseed proteins such as albumins, globulins, glutelin, and prolamins can act against cancer by suppressing cancer cell proliferation, triggering apoptosis, and disrupting oncogenic signaling. These proteins also modulate cancer cell mechanobiology, reducing migration and invasion, and potentially limiting metastasis. This review summarizes current anti-cancer findings and emphasizes the need for further studies to confirm their role in cancer therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/anti-cancer-properties-of-flaxseed-proteome-review/386478/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/anti-cancer-properties-of-flaxseed-proteome-review/386478.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which flaxseed proteins are discussed as having anti-cancer effects?","Question",{"text":112,"@type":113},"The review highlights proteins including albumins, globulins, glutelin, and prolamins found in flaxseed.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do flaxseed proteins exert anti-cancer activity?",{"text":117,"@type":113},"They are described as inhibiting cancer cell proliferation, inducing apoptosis, and interfering with cancer cell signaling pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the role of mechanobiology in the reported anti-cancer effects?",{"text":121,"@type":113},"Flaxseed proteins are reported to modulate cancer cell mechanobiology, leading to altered cell behavior and reduced migration and invasion.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},386478,1790923892,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","proteomes   \nReview  \nAnti-Cancer Properties of Flaxseed Proteome  \nYulia Merkher 1,2, *, Elizaveta Kontareva 1, Anastasia Alexandrova 1, Rajesha Javaraiah 3, Margarita Pustovalova 1,4 and Sergey Leonov 1,4,5  \n1 School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny 141700, Moscow Region, Russia; [leonov.sv@mipt.ru](leonov.sv@mipt.ru) (S.L.)  \n2 Faculty of Biomedical Engineering, Technion–Israel Institute of Technology, Haifa 3200003, Israel  \n3 Department of Biochemistry, Yuvaraja's College, University of Mysore Mysuru, Karnataka 570005, India  \n4 State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC), Moscow 123098, Russia  \n5 Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia  \n* Correspondence: [syuliam@gmail.com](syuliam@gmail.com)  \nAbstract: Flaxseed has been recognized as a valuable source of nutrients and bioactive compounds, including proteins that possess various health benefits. In recent years, studies have shown that flaxseed proteins, including albumins, globulins, glutelin, and prolamins, possess anti-cancer properties. These properties are attributed to their ability to inhibit cancer cell proliferation, induce apoptosis, and interfere with cancer cell signaling pathways, ultimately leading to the inhibition of metastasis. Moreover, flaxseed proteins have been reported to modulate cancer cell mechanobiology, leading to changes in cell behavior and reduced cancer cell migration and invasion. This review provides an overview of the anti-cancer properties of flaxseed proteins, with a focus on their potential use in cancer treatment. Additionally, it highlights the need for further research to fully establish the potential of flaxseed proteins in cancer therapy.  \nCitation: Merkher, Y.; Kontareva, E.; Alexandrova, A.; Javaraiah, R.; Pustovalova, M.; Leonov, S.  \nAnti-Cancer Properties of Flaxseed Proteome. Proteomes 2023, 11, 37 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)proteomes11040037  \nAcademic Editors: Jens R. Coorssen and Matthew P. Padula  \nReceived: 28 August 2023  \nRevised: 6 November 2023  \nAccepted: 10 November 2023  \nPublished: 16 November 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nKeywords: metastasis; flaxseed proteins; cancer treatment; radiotherapy; mechanobiology; proteoform level analysis; flaxseed amino-acids  \n1. Introduction  \nCancer is the second leading cause of mortality worldwide. The majority of cancerrelated deaths (90%) are attributed to metastasis, making its reduction a critical factor in improving patients' survival rates [1] . Recently, there has been a growing proposition that a population of cancer stem cells or cancer initiator cells are responsible for generating highly capable metastatic cells [2–4] . Identifying and targeting specific cell populations with the ability to metastasize is absolutely crucial and of the utmost importance, regardless of the mechanisms involved. This will pave the way for more effective and tailored therapeutics. As metastases from primary tumors often occur in sites that are not easily amenable to surgery, such as bones and the brain, chemotherapy remains the primary therapeutic option. However, conventional chemotherapy is associated with significant side effects due to its impact on all fast-proliferating cells.  \nMetastatic cancers are characterized by the presence of diverse cell populations with varying metastatic abilities and organ specificity. This suggests that the specific molecular characteristics of the metastasizing cells play a crucial rol","cbCainNsH2pon5T0","https://ap.wps.com/l/cbCainNsH2pon5T0","pdf",5663840,23,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"Which flaxseed proteins are discussed as having anti-cancer effects?\",\"answer\":\"The review highlights proteins including albumins, globulins, glutelin, and prolamins found in flaxseed.\"},{\"question\":\"How do flaxseed proteins exert anti-cancer activity?\",\"answer\":\"They are described as inhibiting cancer cell proliferation, inducing apoptosis, and interfering with cancer cell signaling pathways.\"},{\"question\":\"What is the role of mechanobiology in the reported anti-cancer effects?\",\"answer\":\"Flaxseed proteins are reported to modulate cancer cell mechanobiology, leading to altered cell behavior and reduced migration and invasion.\"}]","Anti-Cancer Properties of Flaxseed Proteome - Review | PDF",1790273953,58]