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Biopsies show nodules of immature and mature vascular structures with epithelioid endothelial cells and dense stromal eosinophil-dominant inflammatory infiltrates. Greater awareness supports earlier recognition, accurate diagnosis, and appropriate management to improve 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Website:\u003Cbr>[http://journals.lww.com/TJOP](http://journals.lww.com/TJOP) |\n| DOI:\u003Cbr>10.4103/tjo.TJO-D-23-00119 |\n\nDepartments of 1Ophthalmology and 2Pathology, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India  \n*Address for correspondence:  \nMr. H. Shafeeq Ahmed, K. R. Road, Bangalore Medical College and Research Institute, Bengaluru-560 002, Karnataka, India.  \nE-mail: shafeeqahmed2002 @[gmail.com](gmail.com)[ ](gmail.com)Submission: 14-08-2023  \nAccepted: 18-10-2023  \nPublished: 05-01-2024  \nCase Report  \nTaiwan J Ophthalmol 2025;15:663‑667  \nAngiolymphoid hyperplasia witheosinophilia in the eyelid: A case series and literature review  \nH. Shafeeq Ahmed1*, Chinmayee J. Thrishulamurthy1, Dayananda S. Biligi2,  \nG. Nagaraju1  \nAbstract:  \nAngiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular disorder characterized by the proliferation of blood vessels and lymphoid tissue. While it can occur in various regions of the body, ALHE presenting in the eyelid is relatively uncommon, leading to diagnostic and management challenges. In this case series from South India, we present three unique cases of ALHE specifically affecting the eyelids. Each case illustrates different clinical manifestations, diagnostic workups, and treatment approaches. Tissue biopsies typically reveal nodules comprising immature and mature vascular structures, including capillaries, arterioles, and venules, which are lined by plump endothelial cells with an epithelioid appearance. The surrounding stroma contains a dense infiltrate of inflammatory cells, predominantly eosinophils, histiocytes, lymphocytes, and mast cells. Increased awareness of ALHE in the eyelid will aid ophthalmologists in early recognition, accurate diagnosis, and appropriate management, resulting in improved patient outcomes.  \nKeywords:  \nAngiolymphoid hyperplasia with eosinophilia, biopsy, case report, eyelid, inflammation, kimuras, oculoplastics  \nIntroduction  \nThe diagnosis and management of  \nangiolymphoid hyperplasia witheosinophilia (ALHE) in the eyelid can be challenging due to its variable clinical presentation and rarity. In this case series, we present three unique cases of ALHE specifically affecting the eyelids in Asian patients from South India. Each case highlights different clinical manifestations, diagnostic approaches, and therapeutic interventions. To further enhance our understanding of this intriguing condition, we also conducted a comprehensive literature review to summarize the existing knowledge on ALHEin the eyelid. The objective of this case series and literature review is to shed light on the diverse clinical presentations of eyelid ALHE, offer insights into its diagnostic workup and  \nThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercialNoDerivatives 4.0 License (CC BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nFor reprints [contact:](contact: WKHLRPMedknow_reprints@wolterskluwer.com)[ WKHLRPMedknow_reprints@wolterskluwer.com](contact: WKHLRPMedknow_reprints@wolterskluwer.com)  \nmanagement strategies, and explore the current evidence available in the medical literature. By combining the real‑world experiences of these patients with the findings from the literature, we aim to provide a valuable resource for ophthalmologists and health‑care professionals encountering similar cases. Increased awareness and knowledge about eyelid ALHE will aid in its early recognition, accurate diagnosis, and appropriate treatment, ultimately leading to better patient outcomes. The manuscript adhered to the tenets of the Declaration of Helsinki and written permission was obtained from all patents.  \nCase Presentations  \nCase 1  \nA 38‑year‑old male of Asian descent from S","cbCaigsKBHJo6uTj","https://ap.wps.com/l/cbCaigsKBHJo6uTj","pdf",1098253,"English","# Abstract\n# Introduction\n# Case Presentations\n## Case 1","[{\"question\":\"Why is eyelid ALHE difficult to diagnose and manage?\",\"answer\":\"Eyelid ALHE has variable clinical presentation and is rare, so it poses diagnostic and management challenges despite characteristic pathology.\"},{\"question\":\"What do eyelid ALHE biopsies typically show?\",\"answer\":\"Tissue biopsy usually reveals nodules containing immature and mature vascular structures, with epithelioid-appearing endothelial cells and a dense inflammatory infiltrate predominantly made up of eosinophils.\"},{\"question\":\"What is the aim of the case series and literature review?\",\"answer\":\"To highlight the diverse clinical presentations of eyelid ALHE and provide insights into diagnostic workup and management strategies based on both patient experience and existing medical literature.\"}]","Angiolymphoid hyperplasia with eosinophilia in the eyelid - A case series and literature review | PDF",1790746381,13]