[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328362-105":59,"doc-detail-328362-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","androgens-in-cervical-cancer-their-role-in-epidemiology-and-biology-review","Androgens in cervical cancer: Their role in epidemiology and biology - Review","","Comprehensive review examining the significance of androgens in cervical cancer by combining epidemiological findings with mechanistic biological insights. Cervical cancer is presented as a major global burden, especially in less developed regions with limited HPV screening, and HPV remains a key etiologic factor. The review summarizes evidence that cervical tissues express androgen receptors and that higher endogenous androgen levels increase cervical cancer risk. It explains androgen-driven effects on proliferation, apoptosis, differentiation, and epithelial transformation, and discusses potential androgen–HPV subtype interactions that may influence disease progression and clinical prevention strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/androgens-in-cervical-cancer-their-role-in-epidemiology-and-biology-review/328362/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/androgens-in-cervical-cancer-their-role-in-epidemiology-and-biology-review/328362.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the focus of this review on androgens and cervical cancer?","Question",{"text":112,"@type":113},"The review investigates how androgens contribute to cervical cancer by linking epidemiological evidence to underlying biological mechanisms, including androgen receptor signaling and cellular processes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is cervical cancer epidemiology characterized in the review?",{"text":117,"@type":113},"Cervical cancer is described as the fourth most prevalent cancer among women globally, with higher incidence and mortality in low- and middle-income regions and detailed discussion of incidence, fatalities, and disease types.",{"name":119,"@type":110,"acceptedAnswer":120},"Through what mechanisms might androgens influence cervical carcinogenesis?",{"text":121,"@type":113},"Androgens may act via androgen receptors present in cervical tissue, affecting proliferation, apoptosis, differentiation, and epithelial transformation; the review also considers potential interactions between androgens and specific HPV subtypes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328362,1790049129,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","iScience  \nll  \nOPEN ACCESS  \nReview  \nAndrogens in cervical cancer: Their role in epidemiology and biology  \nYang Gu,1 Qing Mu, 1 and Dali Cheng1,*  \nSUMMARY  \nThis comprehensive review delves into the significance of androgens in cervical cancer, examining both epidemiological evidence and the underlying biological mechanisms. Cervical cancer ranks as the fourth most prevalent cancer among women globally, with disproportionately higher incidence and mortality rates in less developed regions where cervical human papillomavirus (HPV) screening remains limited. Recent research highlights the previously underexplored role of androgens in cervical cancer. Notably, cervical tissues house androgen receptors, and elevated levels of endogenous androgens have been linked to an increased risk of cervical cancer. Androgens exert their influenceon the development and progression of cervical cancer by impacting key cellular processes, including proliferation, apoptosis, differentiation, and epithelial cell transformation. Furthermore, specific HPV subtypes may interact with androgens, potentially modulating HPV-related cellular degeneration and transformation. In light of these findings, it is evident that androgens assume a crucial role in cervical cancer’s pathogenesis. Consequently, further investigations are warranted to deepen our understanding of the intricate relationship between androgens and cervical cancer. Such knowledge advancements can facilitate improved strategies for early prevention and treatment of cervical cancer, especially in regions with limited HPV screening access. This review underscores the importance of considering androgens as a vital component of the multifaceted landscape of cervical cancer etiology and progression, ultimately contributing to more effective clinical interventions.  \nRESEARCH BACKGROUND OVERVIEW  \nEpidemiology of cervical cancer and its characteristics  \nCervical cancer ranks asthe fourth most prevalent cancer among women worldwide, following breast, colorectal, and lung cancers. It results ina staggering 600,000 new cases and 340,000 fatalities annually.1 There are two primary cervical cancer types: squamous cell carcinoma (SCC) and adenocarcinoma, with SCC accounting for over 90% of cases.2 Alarmingly, cervical cancer is disproportionately common in low-and middle-income countries(LMICs), where the incidence rate stands at approximately 11 .3 per 100,000 .3 Even in high-income nations like the United States, the mortality rate from cervical cancer is twice as high among women residing in high-poverty areas compared to their counterparts in low-poverty regions4 (Figure 1) .  \nIn China, approximately 4.57 million new cancer cases were recorded in 2020, with cervical cancer constituting 2.4% of these cases, affecting around 109,741 individuals. During the same period, cancer-related deaths reached around 3 million, with cervical cancer accounting for 2 .0% of this total, resulting in roughly 59,060 deaths (source: International Agency for Research on Cancer [IARC], World Health Organization) . While strides have been made in recognizing cervical cancer as a potentially preventable disease, there has been limited improvement in patient survival rates, resulting in a persistently high cervical cancer burden.5  \nHuman papillomavirus (HPV) is a primary cause of cervical cancer and is classified as a group 1 carcinogen by the IARC. HPV belongs to a family of viruses comprising over 100 known types, though not all are associated with cervical cancer.6 Cervical cancer is categorized into several stages: stage 0, often referred to as carcinoma in situ (CIS); stage 1, typically subdivided into stages 1a and 1b; stage 2, further divided into stages 2a and 2b; stage 3, indicating cancer spread within the pelvic region; and stage 4, representing advanced cancer (Figure 2, adapt[ed from](ed from vagi-wave.co.uk)[ vagi-wave.co.uk](ed from vagi-wave.co.uk)) .  \nRole of androgens in cervical carcinogenesis  \nAlthou","cbCaip57oIlFPC0E","https://ap.wps.com/l/cbCaip57oIlFPC0E","pdf",4183782,14,"English","# Summary\n# Research background overview\n## Epidemiology of cervical cancer and its characteristics\n## Role of androgens in cervical carcinogenesis","[{\"question\":\"What is the focus of this review on androgens and cervical cancer?\",\"answer\":\"The review investigates how androgens contribute to cervical cancer by linking epidemiological evidence to underlying biological mechanisms, including androgen receptor signaling and cellular processes.\"},{\"question\":\"How is cervical cancer epidemiology characterized in the review?\",\"answer\":\"Cervical cancer is described as the fourth most prevalent cancer among women globally, with higher incidence and mortality in low- and middle-income regions and detailed discussion of incidence, fatalities, and disease types.\"},{\"question\":\"Through what mechanisms might androgens influence cervical carcinogenesis?\",\"answer\":\"Androgens may act via androgen receptors present in cervical tissue, affecting proliferation, apoptosis, differentiation, and epithelial transformation; the review also considers potential interactions between androgens and specific HPV subtypes.\"}]","Androgens in cervical cancer: Their role in epidemiology and biology - Review | PDF",1789979458,35]