[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-450427-105":59,"doc-detail-450427-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","androgen-receptor-splice-variant-expression-and-prostate-cancer-recurrence-after-salvage-therapy","Androgen receptor splice variant expression and prostate cancer recurrence after salvage therapy","","Prostate cancer recurrence after radical prostatectomy is addressed by salvage radiotherapy with or without androgen deprivation therapy (ADT), yet treatment failure still occurs. This study hypothesized that androgen receptor (AR) RNA splice variants (ARVs) in primary tumors influence outcomes after subsequent salvage RT plus ADT. Using ultra-deep RNA-seq from prostatectomy specimens of 43 men, 86% showed detectable ARVs, and among 32 unique variants, AR-V7 significantly associated with second biochemical failure. Results suggest AR-V7 may modulate outcomes in localized as well as metastatic prostate cancer.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/androgen-receptor-splice-variant-expression-and-prostate-cancer-recurrence-after-salvage-therapy/450427/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/androgen-receptor-splice-variant-expression-and-prostate-cancer-recurrence-after-salvage-therapy/450427.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-06","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main hypothesis about AR splice variants?","Question",{"text":112,"@type":113},"The study hypothesized that AR RNA splice variants (ARVs) detected in primary prostate cancer may modulate response to subsequent salvage RT plus ADT.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many patients were included, and what treatment sequence did they follow?",{"text":117,"@type":113},"The cohort included 43 men who underwent prostatectomy and later received salvage radiotherapy with concurrent ADT.",{"name":119,"@type":110,"acceptedAnswer":120},"Which AR splice variant was linked to outcomes after salvage RT+ADT?",{"text":121,"@type":113},"AR-V7 was the only detected variant associated with outcomes after salvage RT+ADT, showing a significant association with second biochemical failure.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},450427,1790887816,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","npj | precision oncology Article  \n\n| Published in partnership with The Hormel Institute, University of Minnesota |  | |\n| --- | --- | --- |\n| [https://doi.org/10.1038/s41698-025-01201-3](https://doi.org/10.1038/s41698-025-01201-3) |  |  |\n| Androgen receptor splice variant expression and prostate cancer recurrence after salvage therapy\u003Cbr> Check for updates |  |  |\n| David J. Konieczkowski1,2,9, Keisuke Otani1,3,9, Zoe Guan4, Michael R. Drumm1, Yukako Otani1,3, Priscilla Oluwakemi Badusi1,3, Ella H. Chung1,3, Shulin Wu5, Elai Davicioni6, Philip J. Saylor7, Chin-Lee Wu5, Jason A. Efstathiou1 & David T. Miyamoto1,3,8  |  |  |\n| Prostate cancer is driven by androgen receptor (AR) signaling, and radiotherapy (RT) with or without androgen deprivation therapy (ADT) offers a second opportunity at cure for men with local or biochemical recurrence after prostatectomy. In the metastatic setting, AR RNA splice variants (ARVs), including ligand-independent AR-V7, modulate ADT response and tumor radiosensitivity. Here, we hypothesized that ARVs in primary prostate cancer may likewise modulate response to subsequent salvage RT+ADT. We performed ultra-deep RNA-seq of theAR transcript pool from prostatectomy specimens from 43 men who later received salvage RT+ADT. Eighty-six percent of patients had detectable ARVs (median 3, range 0-12). Of the thirty-two unique ARVs detected, onlyAR-V7 (present in 14% of patients) was associated with outcomes after salvage RT+ADT (HR for second biochemical failure, 6.2, 95% CI 2.3-16.5, p=0.0003) . These results suggest for the first time that AR-V7 may modulate outcomes for localized in addition to metastatic prostate cancer. |  |  |\n| After radical prostatectomy, approximately 20-50% of men experience disease recurrence in the form of a detectable prostate-specific antigen (PSA)1. In the absence of metastatic disease, radiotherapy (RT) to the prostate bed ± regional lymph nodes is a potentially curative salvage treatment for such patients2–4. Recently, several landmark trials have demonstrated additional benefits of adding ADT to salvage RT, including improvements in freedom from progression2,3, metastasis4, and overall survival4. Yet, despite these advances, not all patients are cured by salvage therapy. Prior work has identified clinicopathologic1,5 and genomic6 risk factors associated with second disease recurrence after salvage RT ± ADT. However, at an individual level, it remains challenging to identify which specific individuals with a post-prostatectomy recurrence eligible for salvage therapy are at greatest risk of treatment failure.\u003Cbr>Prostate cancer depends on androgen receptor (AR) signaling for survival, proliferation, and DNA repair7. The expression ofAR splice variants (ARVs) that enable androgen-independent AR signaling has been associated with resistance to AR-targeted therapy in metastatic castrationresistant prostate cancer8–10 as well as to primary ADT in the metastatic | castration-sensitive setting11. Recent in vitro data demonstrate that ARVs also mediate DNA repair after irradiation12, 13, suggesting that ARV expression may also be a biomarker of resistance toRT. Although ARVs are increased in prevalence in metastatic prostate cancer14, some primary prostate tumors do express certain AR variants15. However, the landscape of ARV expression in primary prostate cancer and its potential effect on treatment outcomes remains poorly understood. Here, we hypothesized that ARVs may be detectable in primary prostate cancer and furthermore may modulate response to subsequent salvage RT + ADT.\u003Cbr>Results\u003Cbr>Clinical characteristics of cohort Weidentified43patientswho underwent prostatectomyfollowedby salvage RT with concurrent ADT (Fig. 1a) and had sufficient tissue available for RNA-seq and gene expression analysis (Supplementary Table S1). Median pre-operative PSA was 6.7 ng/mL (range 1.2–88) and most common Gleason score at prostatectomywas4 + 3 = 7(33.3%). Most patients had T3 disease, with 67.4%","cbCaij7NpGgCAFjA","https://ap.wps.com/l/cbCaij7NpGgCAFjA","pdf",1342558,"English","# Clinical courses of patient cohort\n## Treatment course and salvage failure endpoints","[{\"question\":\"What was the study’s main hypothesis about AR splice variants?\",\"answer\":\"The study hypothesized that AR RNA splice variants (ARVs) detected in primary prostate cancer may modulate response to subsequent salvage RT plus ADT.\"},{\"question\":\"How many patients were included, and what treatment sequence did they follow?\",\"answer\":\"The cohort included 43 men who underwent prostatectomy and later received salvage radiotherapy with concurrent ADT.\"},{\"question\":\"Which AR splice variant was linked to outcomes after salvage RT+ADT?\",\"answer\":\"AR-V7 was the only detected variant associated with outcomes after salvage RT+ADT, showing a significant association with second biochemical failure.\"}]","Androgen receptor splice variant expression and prostate cancer recurrence after salvage therapy | PDF",1790733188,23]