[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31610":3,"doc-seo-31610":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31610,1099513958762,"Logic","https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?_k=1776737595927829259",7,"Healthcare","Androgen Biosynthetic Defects: 17b-HSD Type 3 and 5a-Reductase Type 2 Deficiencies","Androgen biosynthetic defects, including 17b-hydroxysteroid dehydrogenase type 3 (17b-HSD3) and 5a-reductase type 2 (5aRD2) deficiencies, represent rare autosomal recessive causes of 46,XY disorders of sex development (DSD). These disorders cause variable undervirilization at birth followed by spontaneous virilization during puberty. Diagnosis depends on hormonal evaluation (T/D4 or T/DHT ratios), while molecular testing confirms etiology. Clinical variability influences fertility, gender transition, and tumor risk, so care must be individualized using molecular, hormonal, and clinical summaries.","cbCaichZezeYudYJ","https://ap.wps.com/l/cbCaichZezeYudYJ","pdf",189543,1,8,"English","en","# Abstract\n# Key Points\n# Introduction\n## Androgen and testosterone synthesis in 46,XY development\n## 17b-HSD type 3 deficiency\n## 5a-reductase type 2 deficiency","[{\"question\":\"What syndromes or genetic conditions are covered for 46,XY DSD?\",\"answer\":\"The content focuses on rare autosomal recessive androgen biosynthetic defects due to 17b-HSD type 3 and 5a-reductase type 2 deficiencies, both affecting 46,XY disorders of sex development.\"},{\"question\":\"How is diagnosis typically established for 17b-HSD3 and 5a-RD2 deficiencies?\",\"answer\":\"Diagnosis relies on hormonal evaluation using ratios such as T/D4 or T/DHT, but definitive diagnosis requires molecular genetic testing to confirm the underlying defect.\"},{\"question\":\"What clinical course and management considerations are emphasized?\",\"answer\":\"Variable undervirilization at birth is followed by spontaneous virilization at puberty, with outcomes affecting fertility potential, gender transition, and tumor risk. Early diagnosis and multidisciplinary, individualized psychosocial and clinical management are highlighted to support gender assignment decisions and long-term outcomes.\"}]",1779829222,20,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"androgen-biosynthetic-defects-17b-hsd-type-3-and-5a-reductase-type-2-deficiencies","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/healthcare/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/androgen-biosynthetic-defects-17b-hsd-type-3-and-5a-reductase-type-2-deficiencies/31610/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-26",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What syndromes or genetic conditions are covered for 46,XY DSD?","Question",{"text":73,"@type":74},"The content focuses on rare autosomal recessive androgen biosynthetic defects due to 17b-HSD type 3 and 5a-reductase type 2 deficiencies, both affecting 46,XY disorders of sex development.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How is diagnosis typically established for 17b-HSD3 and 5a-RD2 deficiencies?",{"text":78,"@type":74},"Diagnosis relies on hormonal evaluation using ratios such as T/D4 or T/DHT, but definitive diagnosis requires molecular genetic testing to confirm the underlying defect.",{"name":80,"@type":71,"acceptedAnswer":81},"What clinical course and management considerations are emphasized?",{"text":82,"@type":74},"Variable undervirilization at birth is followed by spontaneous virilization at puberty, with outcomes affecting fertility potential, gender transition, and tumor risk. Early diagnosis and multidisciplinary, individualized psychosocial and clinical management are highlighted to support gender assignment decisions and long-term outcomes.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]