[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-501229-105":59,"doc-detail-501229-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","anaphylaxis-to-oral-trimethoprim-sulfamethoxazole-in-a-child-a-case-report","Anaphylaxis to Oral Trimethoprim-Sulfamethoxazole in a Child - A Case Report","","Trimethoprim-sulfamethoxazole (TMP-SMX) is a non-β-lactam antibiotic commonly used in pediatrics to treat infections and as a prophylactic medication. Hypersensitivity to TMP-SMX is generally non-immediate, and immediate allergic reactions, including anaphylaxis, are rare. This case report details a six-year-old girl who experienced anaphylaxis to TMP-SMX. Her skin prick test with TMP-SMX was negative, but she developed anaphylaxis in a drug provocation test. An additional basophil activation test for the combination tablet was positive, supporting BAT as a lower-risk diagnostic option than DPT, while further studies are needed.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/anaphylaxis-to-oral-trimethoprim-sulfamethoxazole-in-a-child-a-case-report/501229/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/anaphylaxis-to-oral-trimethoprim-sulfamethoxazole-in-a-child-a-case-report/501229.png","ImageObject",300,407,{"name":92,"@type":93},"4398046744996","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-10-03",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was the child’s TMP-SMX allergy confirmed?","Question",{"text":112,"@type":113},"A drug provocation test with oral TMP-SMX reproduced symptoms consistent with an immediate allergy. The basophil activation test for the TMP-SMX combination tablet was also positive.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What did the skin prick test show?",{"text":117,"@type":113},"The skin prick test with TMP-SMX was negative, so the case proceeded to further diagnostic evaluation.",{"name":119,"@type":110,"acceptedAnswer":120},"Why does the report emphasize basophil activation testing (BAT)?",{"text":121,"@type":113},"The report suggests BAT may provide a safer diagnostic approach than drug provocation testing by lowering risk, although additional studies are required to validate its use for TMP-SMX allergy diagnosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},501229,1792711998,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":66,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":138,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":139,"faqs":140,"seo_title":141,"seo_description":67,"update_tm":142,"read_time":52,"preview_page_count":4},4398046744996,"Review began 01/23/2025  \nReview ended 02/13/2025  \nPublished 02/19/2025  \n© Copyright 2025  \nMabuchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.79317  \nOpen Access Case Report  \nAnaphylaxis to Oral Trimethoprim  \nSulfamethoxazole in a Child: A Case Report  \nHaruna Mabuchi 1, 2, Naoki Kajita 1, Go Kusakawa 1, Kumiko Morita 1, Koichi Yoshida 1  \n1. Division of Allergy, Tokyo Metropolitan Children 's Medical Center, Fuchu, JPN 2. Department of Pediatrics, National Defense Medical College Hospital, Tokorozawa, JPN  \nCorresponding author: Haruna Mabuchi, [angn86hrn@gmail.com](angn86hrn@gmail.com)  \nAbstract  \nTrimethoprim-sulfamethoxazole (TMP-SMX) is a non-β-lactam antibiotic commonly used in pediatrics to treat infections and as a prophylactic medication. Hypersensitivity to TMP-SMX is generally non-immediate, and immediate allergic reactions, including anaphylaxis, are rare. This case report details a six-year-old girl who experienced anaphylaxis to TMP-SMX. Her skin prick test with TMP-SMX was negative, but she developed anaphylaxis in a drug provocation test (DPT) . An additional basophil activation test (BAT) for the TMP-SMX combination tablet was evaluated and was confirmed positive. This case underscores the need for alternative diagnostic methods like BAT, which pose a lower risk than DPT. The findings suggest that BAT could offer a safer diagnostic approach, though more studies are required to validate its use for TMP-SMX allergy diagnosis.  \nCategories: Pediatrics, Allergy/Immunology  \nKeywords: basophil activation test, drug allergy, drug provocation test, pediatric drug hypersensitivity, trimethoprimsulfamethoxazole (tmp-smx)  \nIntroduction  \nTrimethoprim-sulfamethoxazole (TMP-SMX) is a combination of two antimicrobial agents: adiaminopyrimidine (TMP) and a sulfonamide (SMX) [1] . In pediatrics, TMP-SMX is used to treat acute infections such as urinary tract infections and skin infections caused by methicillin-resistant Staphylococcus aureus (MRSA) . It is also used as prophylaxis for pneumocystis pneumonia in immunocompromised patients [2,3] . While TMP-SMX is generally well tolerated, it does have several adverse effects. Dermatologic conditions are the most common, including maculopapular eruption, erythema multiforme, toxic epidermal necrolysis, and Stevens-Johnson syndrome [2,4] . Anaphylactic reactions, although rare, can occur [4,5] . Herein, we describe a pediatric case of anaphylaxis to TMP-SMX confirmed by a drug provocation test (DPT) . In preparing this case report, we explained this report to her guardian and obtained consent.  \nThis case was previously presented as a meeting abstract at the 73rd Annual Meeting of the Japanese Society of Allergy on October 19, 2024.  \nCase Presentation  \nA six-year-old girl had recurrent skin and soft tissue infections such as furuncle and folliculitis since the age of four. She was referred to our infectious diseases department for treatment at the age of four years and nine months because a wound culture revealed MRSA. After that, she took TMP-SMX for treatment, and by the time she was six years old, she had repeated skin infections at least four times. About six months after the last treatment of furuncle, she again experienced swelling with redness around her eye. She took the oral TMP-SMX, and generalized hives and dyspnea appeared after 10 minutes of injection. Two weeks later, similar skin symptoms appeared around her eyes. She took the oral TMP-SMX again, and 10 minutes later, generalized hives and cough appeared. She visited the emergency room during both of those two episodes, but on evaluation in the emergency room, her vitals were normal, she was clinically stable, and she was discharged without any intervention. Other medical h","cbCaih8LhN5aNdBK","https://ap.wps.com/l/cbCaih8LhN5aNdBK","pdf",628079,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"How was the child’s TMP-SMX allergy confirmed?\",\"answer\":\"A drug provocation test with oral TMP-SMX reproduced symptoms consistent with an immediate allergy. The basophil activation test for the TMP-SMX combination tablet was also positive.\"},{\"question\":\"What did the skin prick test show?\",\"answer\":\"The skin prick test with TMP-SMX was negative, so the case proceeded to further diagnostic evaluation.\"},{\"question\":\"Why does the report emphasize basophil activation testing (BAT)?\",\"answer\":\"The report suggests BAT may provide a safer diagnostic approach than drug provocation testing by lowering risk, although additional studies are required to validate its use for TMP-SMX allergy diagnosis.\"}]","Anaphylaxis to Oral Trimethoprim-Sulfamethoxazole in a Child - A Case Report | PDF",1791018198]