[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-595463-105":59,"doc-detail-595463-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","analyzing-population-genetics-using-the-mitochondrial-control-region-bioinformatics","Analyzing Population Genetics Using the Mitochondrial Control Region - Bioinformatics","","The 14-base pair hypervariable region in mitochondrial DNA from Asian populations—specifically Japanese and Chinese students at Plattsburgh State University—was examined using bioinformatics sequence comparison. The study generated mtDNA control-region sequences for 28 Japanese and 27 Chinese international students, plus a control group of 20 random students. Results showed shared 14-base pair sequences in 46% of Japanese, 59% of Chinese, and 75% of control samples, with each group exhibiting distinct mutations within the region.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/analyzing-population-genetics-using-the-mitochondrial-control-region-bioinformatics/595463/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/analyzing-population-genetics-using-the-mitochondrial-control-region-bioinformatics/595463.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-10-15",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What region of mitochondrial DNA was analyzed in this study?","Question",{"text":112,"@type":113},"The study focused on the 14-base pair hypervariable region in mitochondrial DNA (mtDNA) within the mitochondrial control region.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were samples collected and who were the participants?",{"text":117,"@type":113},"mtDNA control-region samples were analyzed from 28 Japanese and 27 Chinese international students, and a control group of 20 random students.",{"name":119,"@type":110,"acceptedAnswer":120},"How were sequences compared and what toolset was used?",{"text":121,"@type":113},"Each sample’s 14-base pair region was analyzed through comparison using bioinformatics.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},595463,1792170820,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","Analyzing Population Genetics Using the Mitochondrial Control  \nRegion and Bioinformatics  \nTakumi Sato, Bonnie Phillips,Sandra M. Latourelle,  \nNancy L. Elwess 1  \n1Department of Biological Sciences, State University of New York at Plattsburgh, 101 Broad St, Plattsburgh, NY 12901  \n[Email: nancy.elwess@plattsburgh.edu](Email: nancy.elwess@plattsburgh.edu)  \nAbstract: The 14-base pair hypervariable region in mitochondrial DNA (mtDNA) of Asian populations, specifically Japanese and Chinese students at Plattsburgh State University, was examined. Previous research on this 14-base pair region showed it to be susceptible to mutations and as a result indicated direct correlation with specific ethnic populations. Earlier studies provided the 14-base pair region sequence analysis for Asians in general. This inquirybased project was generated in a junior/senior college general genetics course. The project produced sequences of the 14-base pair hypervariable region for Japanese and Chinese populations, specifically. The investigation examined 28 Japanese and 27 Chinese international students. A Control group, consisting of 20 random students was also sampled. The 14-base pair hypervariable region for each sample was analyzed through comparison using bioinformatics. Analyzing the samples showed that, overall, 46% of the Japanese samples, 59% of the Chinese samples, and 75% of the Control samples had the same 14-base pair sequence. In addition to this, it was observed that the Japanese, Chinese, and Control group all had their own specific mutations within the 14-base pair hypervariable region.  \nKeywords: DNA, mitochondria, hypervariable region, bioinformatics, data mining  \nIntroduction  \nIn the summer of 2001, the authors of this journal article were chosen to attend the Vector Bioinformatics Workshop held at the Trudeau Institute in Saranac Lake, N.Y  \n([http://www.dnalc.org/ddnalc/about/annreppdf/annre](http://www.dnalc.org/ddnalc/about/annreppdf/annre)[p2001.pdf](p2001.pdf), [2001](2001)) . The workshop was held under the auspices of the Dolan DNA Learning Center (DNALC) located in Cold Spring Harbor, NY and was funded through a Howard Hughes Grant. The five day workshop focused on analyzing patterns in DNA sequences, online algorithms helpful in identifying gene features and using genome browsers to find genes in online databases. Participants were taught to recognize chromosome locations, identify homologs in other organisms, and explore their involvement in normal and disease processes. The workshop also centered on the use of the DNALC‟s custom Bioservers. Participants provided a sample of their own mitochondrial DNA, prepared the sample ([http://www.geneticorigins.org/mito/intro.html](http://www.geneticorigins.org/mito/intro.html)), using Polymerase Chain Reaction (PCR), and submitted it to the DNALC for sequencing. This professional development opportunity subsequently opened the doors to a variety of learning experiences  \nthat could be incorporated into an undergraduate genetics ‟ curriculum. One such opportunity is the focus of this article.  \nThe Nature of Science is such that as one slowly collects information, formulates hypotheses, and explores testable possibilities, the end result is always another fork in the road. Answering one question only creates many more questions. Two General Genetics students did not stop at the knowledge of their own mitochondrial control region sequence of DNA returned to them by the DNALC Bioserver. Once the Vector Bioinformatics Workshop was completed, participants were allowed to submit their students ‟ DNA samples for the sequencing of the mtDNA control region. As a result, undergraduate genetics students were able to use their own DNA sequences to investigate some population genetics questions but the answers still did not satisfy the curiosity factor. The student team found that reading some related journal articles (Anderson et al., 1981; Horai and Hayakawa, 1990; Horai et al., 1993;","cbCaiu2fkQLBYTRV","https://ap.wps.com/l/cbCaiu2fkQLBYTRV","pdf",594520,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What region of mitochondrial DNA was analyzed in this study?\",\"answer\":\"The study focused on the 14-base pair hypervariable region in mitochondrial DNA (mtDNA) within the mitochondrial control region.\"},{\"question\":\"How were samples collected and who were the participants?\",\"answer\":\"mtDNA control-region samples were analyzed from 28 Japanese and 27 Chinese international students, and a control group of 20 random students.\"},{\"question\":\"How were sequences compared and what toolset was used?\",\"answer\":\"Each sample’s 14-base pair region was analyzed through comparison using bioinformatics.\"}]","Analyzing Population Genetics Using the Mitochondrial Control Region - Bioinformatics | PDF",1792081191]