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The primary outcome is cumulative live birth rate, compared using statistical tests and propensity score-based matching to ensure comparability. Results include 136 cancer patients and 241 controls; cancer patients show reduced stimulation duration, lower estradiol, fewer oocytes and embryos, and a lower cumulative live birth rate, while complication rates are similar. Conclusions indicates decreased pregnancy and live birth, especially in endometrial and cervical cancers, with clinical relevance for counseling.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/analysis-of-assisted-reproductive-outcomes-for-gynecologic-cancer-survivors-a-retrospective-study/328463/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/analysis-of-assisted-reproductive-outcomes-for-gynecologic-cancer-survivors-a-retrospective-study/328463.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the primary outcome used to assess assisted reproductive outcomes in this study?","Question",{"text":63,"@type":64},"The primary outcome is the cumulative live birth rate, compared between the gynecologic cancer group and matched infertile controls.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients with gynecologic cancer and controls selected and made comparable?",{"text":68,"@type":64},"Women with gynecologic cancer who underwent their first IVF/ICSI between 2013 and 2021 were retrospectively screened and matched to infertile women without cancer using propensity score-based patient matching and key baseline factors.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main findings regarding live birth and complications?",{"text":72,"@type":64},"Gynecologic cancer patients had a significantly lower cumulative live birth rate than controls, including lower rates within endometrial and cervical cancer subgroups, while maternal and neonatal complications 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\n[https://doi.org/10.1186/s12958-024-01272-0](https://doi.org/10.1186/s12958-024-01272-0)  \nReproductive Biology and Endocrinology  \n RESEARCH Open Access  \nAnalysis of assisted reproductive outcomes   for gynecologic cancer survivors: a retrospective study  \nJing Lin1, Tianying Yang2, Lu Li2, Xiaoxi Sun2,3* and He Li2*  \nAbstract  \nObjective To examine the reproductive outcomes of assisted reproductive technology (ART) in gynecologic cancer patients and to assess maternal and neonatal complications.  \nMethods Women diagnosed with gynecologic cancer who underwent their first in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment between 2013 and 2021 at Shanghai Ji Ai Genetics and IVF Institute were included in this study. Infertile women without any history of cancer were matched to the cancer group. The primary outcome was the cumulative live birth rate. Baseline and follow-up data were compared between groups using Student’s t-tests for normally distributed variables and with Chi-square test for categorical variables. A propensity score-based patient-matching approach was adopted to ensure comparability between individuals with and without specific cancer type.  \nResults A total of 136 patients with a history of gynecologic cancer and 241 healthy infertile controls were included in this study. Endometrial cancer constituted 50. 70% of the cases and cervical cancer constituted 34. 60% of the cases. The cancer group exhibited significantly shorter duration of stimulation, lower levels of estradiol, lower number of retrieved oocytes, day-3 embryos, and blastocysts compared to the control group (P \u003C 0. 05) . The cumulative  \nlive birth rate of the gynecologic cancer group was significantly lower than that of the control group (36 . 10% vs. 60. 50%, P \u003C 0. 001) . Maternal and neonatal complications did not significantly differ between the groups (P>0. 05) . The endometrial cancer and cervical cancer groups showed significantly lower cumulative live birth rates than their matched controls (38 . 60% vs. 64. 50%, P = 0.011 and 24. 20% vs. 68. 60%, P \u003C 0. 001, respectively) .  \nConclusions These findings highlight the decreased occurrence of pregnancy and live birth in female gynecologic cancer patients undergoing ART, particularly in endometrial cancers and cervical cancers. These findings have important implications for counseling and managing gynecologic cancer patients undergoing ART.  \nKeywords Gynecologic cancer, Endometrial cancer, Cervical cancer, Live birth, In vitro fertilization, Assisted reproductive technology  \n*Correspondence: Xiaoxi Sun [xiaoxi_sun@aliyun.com](xiaoxi_sun@aliyun.com)[ ](xiaoxi_sun@aliyun.com)He Li[lihe198900@163.com](lihe198900@163.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/.)[.](http://creativecommons.or","cbCaiptMMUbOszkI","https://ap.wps.com/l/cbCaiptMMUbOszkI","pdf",820663,"English","# Abstract\n# Introduction\n# Materials and methods\n## Study population and design","[{\"question\":\"What is the primary outcome used to assess assisted reproductive outcomes in this study?\",\"answer\":\"The primary outcome is the cumulative live birth rate, compared between the gynecologic cancer group and matched infertile controls.\"},{\"question\":\"How were patients with gynecologic cancer and controls selected and made comparable?\",\"answer\":\"Women with gynecologic cancer who underwent their first IVF/ICSI between 2013 and 2021 were retrospectively screened and matched to infertile women without cancer using propensity score-based patient matching and key baseline factors.\"},{\"question\":\"What were the main findings regarding live birth and complications?\",\"answer\":\"Gynecologic cancer patients had a significantly lower cumulative live birth rate than controls, including lower rates within endometrial and cervical cancer subgroups, while maternal and neonatal complications did not significantly differ between groups.\"}]","Analysis of assisted reproductive outcomes for gynecologic cancer survivors - a retrospective study | PDF",1789979894,25]