[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-440669-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-440669-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","an-unusual-localized-reaction-of-conjunctivitis-with-systemic-use-of-ketoprofen-a-case-report","An Unusual Localized Reaction of Conjunctivitis with Systemic Use of Ketoprofen - A Case Report","","Report an exceedingly rare localized allergic-type hypersensitivity response affecting the eye after systemic ketoprofen use. A 13-year-old girl developed rapid unilateral-to-bilateral swelling, progressive ocular redness, burning and itching, and upper airway obstruction shortly after oral ketoprofen taken for fever and sore throat, without other systemic findings. After desloratadine failed to prevent worsening symptoms, emergency management included antihistamine, corticosteroid, and epinephrine with observation and no delayed reaction. The case underscores the need for further study and detailed laboratory evaluation of NSAID-induced hypersensitivity.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/an-unusual-localized-reaction-of-conjunctivitis-with-systemic-use-of-ketoprofen-a-case-report/440669/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/an-unusual-localized-reaction-of-conjunctivitis-with-systemic-use-of-ketoprofen-a-case-report/440669.png","ImageObject",300,407,{"name":42,"@type":43},"dabgoudw","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the unusual clinical presentation in the case report?","Question",{"text":63,"@type":64},"The patient developed an allergic conjunctivitis with prominent ocular burning and itching plus upper airway obstruction after systemic oral ketoprofen, with no other systemic manifestations.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How soon after taking ketoprofen did symptoms occur?",{"text":68,"@type":64},"Symptoms began shortly after the oral administration of ketoprofen, with ocular discomfort worsening within roughly the same time window after initial dosing and progressing after antihistamine use.",{"name":70,"@type":61,"acceptedAnswer":71},"What emergency treatments were given and what was the outcome?",{"text":72,"@type":64},"Epinephrine was administered promptly, followed by diphenhydramine and methylprednisolone. The patient was observed for 3 hours and discharged in stable condition without delayed reactions.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},440669,1790724819,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},3985747860484,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Case Reports in Ophthalmology  \n\n| Case Rep Ophthalmol 2026;17:1–5 |  |\n| --- | --- |\n| DOI: 10. 1159/000549695\u003Cbr>Received: September 16, 2025\u003Cbr>Accepted: November 19, 2025\u003Cbr>Published online: November 28, 2025 | © 2025 The Author(s) .\u003Cbr>Published by S. Karger AG, Basel [www.karger.com/cop](www.karger.com/cop) |\n\nThis article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC) ([https://karger.com/Services/OpenAccessLicense](https://karger.com/Services/OpenAccessLicense)). Usage and distribution for commercial purposes requires written permission.  \nCase Report  \nAn Unusual Localized Reaction of Conjunctivitis with Systemic Use of Ketoprofen: A Case Report  \nMarcio Antonio Rodrigues Araujo  \nDepartment of Physiological Sciences, Federal University of Maranhão, São Luís, Brazil  \nKeywords  \nKetoprofen · Conjunctivitis · Adverse reactions · Case report · Hypersensibility  \nAbstract  \nIntroduction: Although the eye is rarely the sole target of an immediate allergic-type response, ocular signs and symptoms often represent the most prominent features of systemic allergic reactions. Nonsteroidal anti-inflammatory drugs (NSAIDs), due to their cyclooxygenase inhibitory activity, can trigger nonallergic hypersensitivity responses. Ketoprofen, in particular, is one of the most potent cyclooxygenase inhibitors at therapeutic plasma concentrations and is recognized asa frequent photoallergic agent. However, localized hypersensitivity reactions following systemic administration are exceedingly rare. This report describes an unusual case of allergic conjunctivitis occurring after oral administration of ketoprofen. Case Presentation: A 13-year-old Caucasian girl presented to the pediatric emergency department of a private hospital with swelling, progressive ocular redness, burning, itching, and upper airway obstruction. These symptoms developed shortly after the oral administration of ketoprofen (20 mg/mL), prescribed to manage a low-grade fever (37.9°C) and sore throat. No additional systemic manifestations were observed. Conclusion: An uncommon case of conjunctivitis following oral ketoprofen use highlights the need for further research on NSAID-induced hypersensitivity and the value of detailed laboratory evaluation to clarify its causes.  \n© 2025 The Author(s) .  \nPublished by S. KargerAG, Basel  \nCase Presentation  \nA 13-year-old girl of Caucasian descent (1.56 m, 45 kg) presented with fever (37.9°C), throat pain, and inflammation. Thirty drops of ketoprofen (20 mg/mL) were administered orally at home. Approximately 30–40 min later, she complained of a burning sensation in her  \nCorrespondence to:  \nMarcio Antonio Rodrigues Araujo, araujo.marcio  [ufma.br](ufma.br)  \nCase Reports in Ophthalmology  \nCase Rep Ophthalmol 2026;17:1–5 2  \n\n| DOI: 10. 1159/000549695 | © 2025 The Author(s) . Published by S. Karger AG, Basel [www.karger.com/cop](www.karger.com/cop) |\n| --- | --- |\n\nAraujo: Allergic Conjunctivitis due to Oral Ketoprofen: A Case Report  \neyes, followed by rhinorrhea, although she did not experience photosensitivity while watching television. Clinically, the periorbital region exhibited edema and progressive erythema, accompanied by conjunctival hyperemia. The patient subsequently received one tablet of desloratadine (5 mg; Desalex™, Schering-Plough S.A., Mexico). The intensity of her ocular discomfort escalated, with severe burning, itching, and upper airway obstruction, but no other systemic manifestations. Approximately 30 min after receiving the antihistamine, she was taken to the pediatric emergency department of a private hospital, arriving while breathing exclusively through her mouth. Clinical examination revealed pruritus and bilateral ocular edema and mild odynophagia. Epinephrine (0.3 mL, 1 mg/mL) was promptly administered, followed by diphenhydramine (0.9 mL, 50 mg/mL) and methylprednisolone (1.8 mL). The patient remained under observation for 3 h and was discharged","cbCaipmE7ltiLOBE","https://ap.wps.com/l/cbCaipmE7ltiLOBE","pdf",1783640,"English","# Introduction\n# Case Presentation\n# Discussion\n# Conclusion","[{\"question\":\"What was the unusual clinical presentation in the case report?\",\"answer\":\"The patient developed an allergic conjunctivitis with prominent ocular burning and itching plus upper airway obstruction after systemic oral ketoprofen, with no other systemic manifestations.\"},{\"question\":\"How soon after taking ketoprofen did symptoms occur?\",\"answer\":\"Symptoms began shortly after the oral administration of ketoprofen, with ocular discomfort worsening within roughly the same time window after initial dosing and progressing after antihistamine use.\"},{\"question\":\"What emergency treatments were given and what was the outcome?\",\"answer\":\"Epinephrine was administered promptly, followed by diphenhydramine and methylprednisolone. The patient was observed for 3 hours and discharged in stable condition without delayed reactions.\"}]","An Unusual Localized Reaction of Conjunctivitis with Systemic Use of Ketoprofen - A Case Report | PDF",1790692911,13]