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The analysis integrates GWAS summary data, eQTL evidence, TCGA and GTEx expression datasets, and applies PheWAS, polygenic risk scoring, and one-sample and two-sample Mendelian randomization. Results show psoriasis-associated higher risks across 16 cancer types in unselected PheWAS, and causal links for breast and lung cancer in two-sample MR, supported by gene annotation differences in relevant tissues.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/an-observational-and-genetic-investigation-into-the-association-between-psoriasis-and-risk-of-malignancy/331272/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/an-observational-and-genetic-investigation-into-the-association-between-psoriasis-and-risk-of-malignancy/331272.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main goal of the study?","Question",{"text":112,"@type":113},"To determine whether psoriasis is causally associated with site-specific cancers using both observational and genetic approaches.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which analytical methods were used to assess cancer associations?",{"text":117,"@type":113},"PheWAS, polygenic risk score analysis, and one-sample and two-sample Mendelian randomization analyses.",{"name":119,"@type":110,"acceptedAnswer":120},"What cancers showed causal association with genetically predicted psoriasis?",{"text":121,"@type":113},"Two-sample Mendelian randomization indicates causal associations with breast cancer and lung cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331272,1790471783,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Article [https://doi.org/10.1038/s41467-024-51824-6](https://doi.org/10.1038/s41467-024-51824-6)  \nAn observational and genetic investigation into the association between psoriasis and risk of malignancy  \nReceived: 7 January 2024  \n\n| Accepted: 16 August 2024 |\n| --- |\n| |\n| Check for updates |\n\nRuolin Li 1,3, Wenjin Luo 2,3, Xiangjun Chen 2, Qinglian Zeng 2, Shumin Yang 2, Ping Wang 1, Jinbo Hu 2  & Aijun Chen 1  \nThe relationship between psoriasis and site-specific cancers remains unclear. Here, we aim to investigate whether psoriasis is causally associated with sitespecific cancers. We use observational and genetic data from the UK Biobank, obtaining GWAS summary data, eQTL analysis data, TCGA data, and GTEx data from public datasets. We perform PheWAS, polygenic risk score analysis, and one-sample and two-sample Mendelian randomization analyses to investigate the potential causal associations between psoriasis and cancers. In the unselected PheWAS analysis, psoriasis is associated with higher risks of 16 types of cancer. Using one-sample Mendelian randomization analyses, it is found that genetically predicted psoriasis is associated with higher risks of anal canal cancer, breast cancer, follicular non-Hodgkin’s lymphoma and nonmelanoma skin cancer in women; and lung cancer and kidney cancer in men. Our twosample Mendelian randomization analysis indicates that psoriasis is causally associated with breast cancer and lung cancer. Gene annotation shows that psoriasis-related genes, such as ERAP1, are significantly different in lung and breast cancer tissues. Taken together, clinical attention to lung cancer and breast cancer may be warranted among patients with psoriasis.  \nPsoriasis is an immune-system-mediated inflammatory skin disease that affects approximately 3% of the population1. Cancer has been reported to be one of the leading causes in patients with psoriasis2, but the association between psoriasis and the risk of site-specific cancers remains unclear. A meta-analysis that included cohort or case-control studies indicated that psoriasis was associated with an increased risk of developing 11 types of site-specific cancers, including colon, colorectal, kidney, laryngeal, liver, lymphoma, keratinocyte, esophageal, oral cavity, pancreatic cancers, and nonHodgkin lymphoma3. However, another meta-analysis including cohort studies found that patients with psoriasis or psoriatic arthritis had higher risks of keratinocyte cancer, lymphoma, lung cancer, and bladder cancer4. These inconsistent results might be ascribed, at least partially, to limited sample sizes, varied diagnostic  \ncriteria of psoriasis, and insufficient adjustments for potential confounders.  \nPsoriasis has a significant hereditary predisposition5. Genomewide association studies (GWASs) have identified several susceptibility loci of psoriasis involved in immune-mediated inflammatory disordersand innate/acquired host defense6, leading to a higher possibility of developing cancer for patients with psoriasis1,7,8. Although integrating genetic data into analyses of the polygenic risk score (PRS) or Mendelian randomization(MR) is an effective approach to exploring causal effects on outcomes9,10, different MR studies lead to controversial results regarding the causal association between psoriasis and cancer11–13.  \nTo date, systematic explorations based on a large-scale cohort with genetic data examining the relationship between psoriasis and the  \n1Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 2Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 3These authors contributed equally: Ruolin Li, Wenjin Luo.  \ne-mail: [hujinbo@cqmu.edu.cn](hujinbo@cqmu.edu.cn); [chenaijun@hospital.cqmu.edu.cn](chenaijun@hospital.cqmu.edu.cn)  \nincidence of malignancy are lacking. In this study, we systematically explored associations between psoriasis and 89 types of cancers in","cbCaim5XnMLIA3pc","https://ap.wps.com/l/cbCaim5XnMLIA3pc","pdf",1304905,11,"English","# Results\n## Baseline characteristics\n## Observational PheWAS","[{\"question\":\"What was the main goal of the study?\",\"answer\":\"To determine whether psoriasis is causally associated with site-specific cancers using both observational and genetic approaches.\"},{\"question\":\"Which analytical methods were used to assess cancer associations?\",\"answer\":\"PheWAS, polygenic risk score analysis, and one-sample and two-sample Mendelian randomization analyses.\"},{\"question\":\"What cancers showed causal association with genetically predicted psoriasis?\",\"answer\":\"Two-sample Mendelian randomization indicates causal associations with breast cancer and lung cancer.\"}]","An Observational and Genetic Investigation into the Association between Psoriasis and Risk of Malignancy | PDF",1789992510,28]