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Genetic and protein survivin profiles in buccal tissue of oral squamous cell carcinoma (OSCC) among South Indian tobacco chewers have not been previously examined. This study quantifies buccal survivin via ELISA, evaluates associations with pretreatment hematological parameters, and analyzes BIRC5 gene sequences to link variant patterns with survivin concentrations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/an-insight-into-survivin-in-relevance-to-hematological-biochemical-and-genetic-characteristics-in-tobacco-chewers-with-oral-squamous-cell-carcinoma/382425/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/an-insight-into-survivin-in-relevance-to-hematological-biochemical-and-genetic-characteristics-in-tobacco-chewers-with-oral-squamous-cell-carcinoma/382425.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the role of Survivin in cancer biology and why is BIRC5 important?","Question",{"text":112,"@type":113},"Survivin inhibits apoptosis and is encoded by the BIRC5 gene. It is expressed in various cancers and is associated with tumor resistance to radiation and chemotherapy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were buccal tissue survivin levels measured and how were participants grouped?",{"text":117,"@type":113},"Buccal tissue survivin levels were measured using ELISA in a single centric case control design. Participants were divided into OSCC tobacco chewers, non-OSCC tobacco chewers, and healthy controls.",{"name":119,"@type":110,"acceptedAnswer":120},"Which hematological parameters were linked to Survivin levels in the study?",{"text":121,"@type":113},"Pretreatment absolute monocyte count (AMC), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR) showed significant associations with survivin levels.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382425,1790626696,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","cells  \nArticle  \nAn Insight into Survivin in Relevance to Hematological, Biochemical and Genetic Characteristics in Tobacco Chewers with Oral Squamous Cell Carcinoma  \nSusanna Theophilus Yesupatham 1, C. D. Dayanand 2,*, S. M. Azeem Mohiyuddin 3 and M. L. Harendra Kumar 4  \nCitation: Yesupatham, S.T.; Dayanand, C.D.; Azeem Mohiyuddin, S.M.; Harendra Kumar, M.L. An Insight into Survivin in Relevance to Hematological, Biochemical and Genetic Characteristics in Tobacco Chewers with Oral Squamous Cell Carcinoma. Cells 2023, 12, 1444 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cells12101444  \nAcademic Editors: Jozsef Dudas and Nejat Düzgüne¸s  \nReceived: 18 March 2023  \nRevised: 4 May 2023  \nAccepted: 6 May 2023  \nPublished: 22 May 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Biochemistry, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar 563103, Karnataka, India; [susanna020682@gmail.com](susanna020682@gmail.com)  \n2 Allied Health and Basic Sciences, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar 563103, Karnataka, India  \n3 Department of Otorhinolaryngology and Head and Neck Surgery, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar 563103, Karnataka, India  \n4 Department of Pathology, Shridevi Institute of Medical Sciences and Research Hospital, Sira Road, Tumakuru 572106, Karnataka, India  \n* Correspondence: [cd8905@yahoo.co.in](cd8905@yahoo.co.in)  \nAbstract: Background: Survivin is an inhibitor of apoptosis protein (IAP), encoded by the Baculoviral IAP Repeat Containing 5 (BIRC5) gene located on q arm (25.3) on chromosome 17 . It is expressed in various human cancers and involved in tumor resistance to radiation and chemotherapy. The genetic analysis of the BIRC5 gene and its protein survivin levels in buccal tissue related to oral squamous cell carcinoma (OSCC) in South Indian tobacco chewers has not been studied. Hence, the study was designed to quantify survivin in buccal tissue and its association with pretreatment hematological parameters and to analyze the BIRC5 gene sequence. Method: In a single centric case control study, buccal tissue survivin levels were measured by ELISA. A total of 189 study subjects were categorized into Group 1 (n = 63) habitual tobacco chewers with OSCC, Group 2 (n = 63) habitual tobacco chewers without OSCC, and Group 3 (n = 63) healthy subjects as control. Retrospective hematological data were collected from Group 1 subjects and statistically analyzed. The BIRC5 gene was sequenced and data were analyzed using a bioinformatics tool. Results: Survivin protein mean 􀀆 SD in Group 1 was (1670.9 􀀆 796.21 pg/mL), in Group 2 it was (1096.02 􀀆 346.17 pg/mL), and in Group 3 it was (397.5 􀀆 96.1 pg/mL) with significance (p \u003C 0.001) . Survivin levels showed significance with cutoff levels of absolute monocyte count (AMC), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR) at (p = 0.001) . The unique variants found only in OSCC patients were T ! G in the promoter region, G ! C in exon 3, C ! A, A ! G, G ! T, T ! G, A ! C, G ! A inexon 4, C ! A, G ! T, G ! C in the exon 5 region. Conclusions: The tissue survivin level increased in OSCC patients compared to controls; pretreatment AMC, LMR, and NLR may serve as add-on markers along with survivin to measure the progression of OSCC. Unique mutations in the promoterand exons 3–5 were observed in sequence analysis and were associated with survivin concentrations.  \nKeywords: survivin; BIRC5; NLR; LMR; PLR; OSCC; nicotine  \n1. Introduction  \nOral cancer is one of the most frequent malignant tumors worldwide","cbCaiaFeZLql1C45","https://ap.wps.com/l/cbCaiaFeZLql1C45","pdf",2501161,28,"English","# Abstract\n# Introduction","[{\"question\":\"What is the role of Survivin in cancer biology and why is BIRC5 important?\",\"answer\":\"Survivin inhibits apoptosis and is encoded by the BIRC5 gene. It is expressed in various cancers and is associated with tumor resistance to radiation and chemotherapy.\"},{\"question\":\"How were buccal tissue survivin levels measured and how were participants grouped?\",\"answer\":\"Buccal tissue survivin levels were measured using ELISA in a single centric case control design. Participants were divided into OSCC tobacco chewers, non-OSCC tobacco chewers, and healthy controls.\"},{\"question\":\"Which hematological parameters were linked to Survivin levels in the study?\",\"answer\":\"Pretreatment absolute monocyte count (AMC), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR) showed significant associations with survivin levels.\"}]","An Insight into Survivin in Relevance to Hematological, Biochemical and Genetic Characteristics in Tobacco Chewers with Oral Squamous Cell Carcinoma | PDF",1790250359,71]