[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31105":3,"doc-seo-31105":21},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"update_tm":20},31105,4398048950312,"Violet","https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908",8,"Research & Report","An Effective Approach in Osteoarthritis Diacerein Loaded Solid Lipid","Osteoarthritis is a progressive degenerative joint disease marked by cartilage loss, subchondral bone changes, joint narrowing, pain aggravated by activity, and morning stiffness, with inflammatory pathways increasingly recognized as central to disease progression. Diacerein (DC), an anthraquinone-derived anti-inflammatory agent with anti-catabolic and pro-anabolic effects, targets interleukin-1β signaling to reduce chondrocyte inflammatory transduction and protect joint tissues. Major clinical limitations include poor aqueous stability, low solubility and bioavailability, short half-life, and gastrointestinal adverse effects. Solid lipid nanoparticles are investigated as carriers to improve stability, taste masking, prolonged release, and delivery for localized osteoarthritis therapy using optimized formulation strategies.","cbCaiiDOImkPKCrr","https://ap.wps.com/l/cbCaiiDOImkPKCrr","pdf",5726483,1,1778619677,{"code":4,"msg":22,"data":23},"ok",{"site_id":24,"language":25,"slug":26,"title":13,"keywords":27,"description":14,"schema_data":28,"social_meta":62,"head_meta":64,"extra_data":66,"updated_unix":20},105,"en","an-effective-approach-in-osteoarthritis-diacerein-loaded-solid-lipid","",{"@graph":29,"@context":61},[30,47],{"@type":31,"itemListElement":32},"BreadcrumbList",[33,37,41,44],{"item":34,"name":35,"@type":36,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":38,"name":39,"@type":36,"position":40},"https://docshare.wps.com/document/","Document",2,{"item":42,"name":12,"@type":36,"position":43},"https://docshare.wps.com/document/research-report/",3,{"item":45,"name":13,"@type":36,"position":46},"https://docshare.wps.com/document/an-effective-approach-in-osteoarthritis-diacerein-loaded-solid-lipid/31105",4,{"url":45,"name":13,"@type":48,"author":49,"headline":13,"publisher":51,"fileFormat":54,"description":14,"dateModified":55,"datePublished":55,"encodingFormat":54,"isAccessibleForFree":56,"interactionStatistic":57},"DigitalDocument",{"name":9,"@type":50},"Person",{"url":34,"name":52,"@type":53},"DocShare","Organization","application/pdf","2026-05-12",true,{"@type":58,"interactionType":59,"userInteractionCount":4},"InteractionCounter",{"@type":60},"ViewAction","https://schema.org",{"og:url":45,"og:type":63,"og:title":13,"og:site_name":52,"og:description":14},"article",{"robots":65,"canonical":45},"index,follow",{"doc_id":7,"site_id":24}]