[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328264-105":59,"doc-detail-328264-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","an-analysis-of-aurkbs-prognostic-and-immunological-roles-across-various-cancers","An analysis of AURKB's prognostic and immunological roles across various cancers","","Aurora kinase B (AURKB), a key mitotic regulator, is investigated for its multifaceted role in cancer development and progression, while underlying mechanisms remain incompletely defined. Bioinformatics analyses evaluate AURKB transcript, protein, promoter methylation and mutation patterns across cancer types, including links to prognosis, pathological stage, immune infiltration, tumor mutational burden (TMB) and microsatellite instability (MSI). Immunohistochemistry confirms differential AURKB protein expression in renal clear cell carcinoma versus adjacent normal tissues. Results indicate high AURKB expression in most cancers and associations with survival and advanced stage.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/an-analysis-of-aurkbs-prognostic-and-immunological-roles-across-various-cancers/328264/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/an-analysis-of-aurkbs-prognostic-and-immunological-roles-across-various-cancers/328264.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What does AURKB do in cell division according to the study?","Question",{"text":113,"@type":114},"AURKB is described as an essential regulator of mitosis, the process required for cell division.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which data types were used to characterize AURKB in multiple cancers?",{"text":118,"@type":114},"The study uses bioinformatics to analyze AURKB transcript, protein, promoter methylation, and mutation levels, and relates them to prognosis and immune features such as TMB and MSI.",{"name":120,"@type":111,"acceptedAnswer":121},"How was the study validated in renal clear cell carcinoma?",{"text":122,"@type":114},"Immunohistochemical staining data from 50 cases of renal clear cell carcinoma and adjacent normal tissues were collected to verify differences in AURKB protein expression.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},328264,1790176217,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","DOI: 10. 1111/jcmm.18475  \nOR I G I NAL ART I C L E  \nAn analysis of AURKB's prognostic and immunological roles across various cancers  \nJun Li1  | Cui Cheng2  | Jiajun Zhang1  \n1Department of Urology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China  \n2Department of Gynaecological Oncology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China  \nCorrespondence  \nJiajun Zhang, Department of Urology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233004, China.  \nEmail: [zsyf777@126.com](zsyf777@126.com)  \nFunding information  \nBengbu Medical College, Grant/Award Number: KJ2020A1290  \nAbstract  \nAurora kinase B (AURKB), an essential regulator in the process of mitosis, has been revealed through various studies to have a significant role in cancer development and progression. However, the specific mechanisms remain poorly understood. This study, therefore, seeks to elucidate the multifaceted role of AURKB in diverse cancer types. This study utilized bioinformatics techniques to examine the transcript, protein, promoter methylation and mutation levels of AURKB. The study further analysed associations between AURKB and factors such as prognosis, pathological stage, biological function, immune infiltration, tumour mutational burden (TMB) and microsatellite instability (MSI) . In addition, immunohistochemical staining data of 50 cases of renal clear cell carcinoma and its adjacent normal tissues were collected to verify the difference in protein expression of AURKB in the two tissues. The results show that AURKB is highly expressed in most cancers, and the protein level of AURKB and the methylation level of its promoter vary among cancer types. Survival analysis showed that AURKB was associated with overall survival in 12 cancer types and progression-free survival in 11 cancer types. Elevated levels of AURKB were detected in the advanced stages of 10 different cancers. AURKB has a potential impact on cancer progression through its effects on cell cycle regulation as well as inflammatory and immunerelated pathways. We observed a strong association between AURKB and immune cell infiltration, immunomodulatory factors, TMB and MSI. Importantly, we confirmed that the AURKB protein is highly expressed in kidney renal clear cell carcinoma (KIRC) . Our study reveals that AURKB may be a potential biomarker for pan-cancer and KIRC.  \nK E Y WO R D S  \nbiomarker, cell cycle, immune infiltration, immunotherapy, kidney renal clear cell carcinoma, pan-cancer  \n1 | INTRODUCTION  \nAccording to the 2020 statistics provided by the International Agency for Research on Cancer, there has been an increasing  \nincidence of cancer each year, constituting a substantial threat to both public health and the economy.1 Current cancer treatment modalities include surgical intervention, chemotherapy and radiation therapy. Additionally, targeted therapy and immunotherapy  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s) . Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.  \nJ Cell Mol Med. 2024;28:e18475 .  \n[https://doi.org/10.1111/jcmm.18475](https://doi.org/10.1111/jcmm.18475)  \n[wileyonlinelibrary.com/journal/jcmm](wileyonlinelibrary.com/journal/jcmm)  \n1 of 19  \nare emerging as innovative strategies in the battle against cancer. Despite some clinical successes, targeted therapy and immunotherapy are often hampered by factors such as negative drug targets or immune checkpoints, the development of tumour resistance and severe toxic side effects.2–4 As a result, the ongoing search for novel markers and therapeutic targets that are highly specific or sensitive is of paramount importance in contemporary cancer research.5  \nThe complexity of cancer de","cbCaimnxxb5YDS3K","https://ap.wps.com/l/cbCaimnxxb5YDS3K","pdf",23484273,"English","# Abstract\n# 1 | INTRODUCTION","[{\"question\":\"What does AURKB do in cell division according to the study?\",\"answer\":\"AURKB is described as an essential regulator of mitosis, the process required for cell division.\"},{\"question\":\"Which data types were used to characterize AURKB in multiple cancers?\",\"answer\":\"The study uses bioinformatics to analyze AURKB transcript, protein, promoter methylation, and mutation levels, and relates them to prognosis and immune features such as TMB and MSI.\"},{\"question\":\"How was the study validated in renal clear cell carcinoma?\",\"answer\":\"Immunohistochemical staining data from 50 cases of renal clear cell carcinoma and adjacent normal tissues were collected to verify differences in AURKB protein expression.\"}]","An analysis of AURKB's prognostic and immunological roles across various cancers | PDF",1789979107,48]