[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31430":3,"doc-seo-31430":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31430,34359740700684,"Finn","https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487",8,"Research & Report","Amplifying Synergistic Effects of Cuproptosis and Bacterial Membrane Vesicles-Mediated Photothermal Therapy by Multifunctional Nano-Biohybrid for Anti-Tumor Immunotherapy","Study develops a multifunctional nano-biohybrid, CuM@RR, by loading Cu-based metal–organic framework nanoparticles into DSPE-PEG2000-RGD-functionalized Rhodobacter sphaeroides-derived bacterial membrane vesicles. The RGD modification enables targeted delivery to tumor sites. In acidic tumor microenvironments CuM releases Cu2+, inducing cuproptosis, while 808 nm irradiation generates photothermal heat that drives apoptosis. Immunogenic cell death releases DAMPs and tumor antigens to activate anti-tumor immunity, and in vivo results show tumor suppression and resistance to rechallenge with minimal systemic toxicity.","cbCaisIyWXt1FmnF","https://ap.wps.com/l/cbCaisIyWXt1FmnF","pdf",10092559,1,16,"English","en","# Introduction\n## Bacterial membrane vesicles and immune adjuvant roles\n## Rhodobacter sphaeroides-derived vesicles for photothermal therapy\n## Need for synergistic multi-therapeutic strategies\n# CuM@RR design and targeted delivery\n# Synergistic mechanism: photothermal apoptosis and cuproptosis\n# Immunogenic cell death and anti-tumor immune response\n# In vivo therapeutic performance and safety","[{\"question\":\"What is CuM@RR and how is it constructed?\",\"answer\":\"CuM@RR is built by encapsulating Cu-based metal–organic framework nanoparticles into DSPE-PEG2000-RGD-functionalized Rhodobacter sphaeroides-derived bacterial membrane vesicles (RMVs). The vesicle functionalization provides both targeting ability and cargo capacity.\"},{\"question\":\"How does CuM@RR induce cuproptosis in tumor cells?\",\"answer\":\"CuM core decomposes in the acidic tumor microenvironment, releasing Cu2+. Excess copper triggers cuproptosis by engaging lipoylated proteins in the TCA cycle and causing downstream proteotoxic stress leading to cell death.\"},{\"question\":\"How does photothermal therapy synergize with cuproptosis to enhance anti-tumor immunity?\",\"answer\":\"Under 808 nm NIR irradiation, photothermal heating promotes apoptosis, which together with copper overload-induced cuproptosis causes strong immunogenic cell death. Released DAMPs and tumor-associated antigens stimulate dendritic cell maturation and cytotoxic T lymphocyte activation, resulting in robust anti-tumor immune responses.\"}]",1779483652,40,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"amplifying-synergistic-effects-of-cuproptosis-and-bacterial-membrane-vesicles-mediated-photothermal-therapy-by-multifunctional-nano-biohybrid-for-anti-tumor-immunotherapy","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/amplifying-synergistic-effects-of-cuproptosis-and-bacterial-membrane-vesicles-mediated-photothermal-therapy-by-multifunctional-nano-biohybrid-for-anti-tumor-immunotherapy/31430/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-22",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What is CuM@RR and how is it constructed?","Question",{"text":73,"@type":74},"CuM@RR is built by encapsulating Cu-based metal–organic framework nanoparticles into DSPE-PEG2000-RGD-functionalized Rhodobacter sphaeroides-derived bacterial membrane vesicles (RMVs). The vesicle functionalization provides both targeting ability and cargo capacity.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How does CuM@RR induce cuproptosis in tumor cells?",{"text":78,"@type":74},"CuM core decomposes in the acidic tumor microenvironment, releasing Cu2+. Excess copper triggers cuproptosis by engaging lipoylated proteins in the TCA cycle and causing downstream proteotoxic stress leading to cell death.",{"name":80,"@type":71,"acceptedAnswer":81},"How does photothermal therapy synergize with cuproptosis to enhance anti-tumor immunity?",{"text":82,"@type":74},"Under 808 nm NIR irradiation, photothermal heating promotes apoptosis, which together with copper overload-induced cuproptosis causes strong immunogenic cell death. Released DAMPs and tumor-associated antigens stimulate dendritic cell maturation and cytotoxic T lymphocyte activation, resulting in robust anti-tumor immune responses.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]