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The text explains how heredity may influence development in some families, while in most cases close relatives have only a slightly higher lifetime risk. It also describes the gradual onset and typical symptom pattern, including memory decline, personality and thinking changes, behavioral and functional deterioration, and the eventual complications that may lead to death. 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However, overall knowledge of the genetic aspects is limited, and most individuals’ risk is only slightly higher than the general population.",{"name":119,"@type":110,"acceptedAnswer":120},"What symptoms may appear over time in Alzheimer’s Disease?",{"text":121,"@type":113},"The text notes early problems with recent or short-term memory, mild personality changes, and later difficulties with abstract thinking and daily functioning. 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\nAkheieRC523C641987  \nU.S.DEPARTMENT OF HEALTH ANDHUMAN SERVICES  \nPublic Health Service  \nAlcohol,Drug Abuse,and Mental Health Administration  \nDigitized by the Internet Archivein 2020 with funding fromKahle/Austin Foundation  \nUseful Information On...RC523。C641987IAlzheimersDiseaseU.S.DEPARTMENT OF HEALTH ANDHUMAN SERVICESPublic Health ServiceAlconoil,Drug Abuse,and Mental HealthAdministration  \nby  \nGene D.Cohen,M.D.,Ph.D.DirectorNIMH Program on Aging  \nNational Institute of Mental Health5600 Fishers LaneRockville,Maryland 20857  \n# Introduction\n\nAlzheimer's Disease(AD)is not a normalpart of aging.It is not something that inevitablyhappens in later life.Rather,it is a disease ofunknown cause that affects a small but signifi-cant percentage of people 65 years and older.  \nAD is the exception,rather than the rule,inold age.Only 5 to 6 percent of older peopledevelop AD-but this means approximately 2million Americans are affected.At least half thepeople in U.S.nursing homes have AD or a relateddisorder,incurring costs in excess of 20 billiondollars annually.  \nIt is important to learn about AD because,although the disorder is not curable or revers-ible,there are ways to alleviate symptoms andsuffering and assist families.  \nAmong the terms that have been used todescribe AD have been senile dementia,SDAT(senile dementia of the Alzheimer type),pre-senile dementia(when the disorder has its onsetprior to age 65),primary degenerative dementia,organic brain syndrome (OBS),and senility.\"Senility\"is not a medical term;it is nonspecificand misleading.Often,it has been used to  \ndescribe AD and a range of reversible problemseither misdiagnosed as AD or inappropriatelydismissed as being untreatable.  \n# Who Gets Alzheimer's Disease?\n\nA family pattern of AD has been describedby various investigators,suggesting that hered-ity may influence its development.Other  \nresearchers,however,emphasize that we knowlittle about the genetic aspects of the disorder.Agenetic basis,at least with a small subgroup offamilies where the disease has more frequentlyoccurred,has been identified through the dis-  \ncovery of a genetic marker on chromosome 21 inthose particular families.At the same time,dataindicate that the likelihood of a close relative(sibling,child.or parent)of an afflicted individualdeveloping AD is low.In most cases,such anindividual's risk is only slightly higher than thatof someone in the general population,where the  \nlifetime risk is below 1 percent.It should also bepointed out that many disorders have a geneticpotential which is never expressed-that is,despite being at risk for a certain illness,onemight go through life without the disease everdeveloping.In other instances,a genetic poten-tial for a certain disorder may be released only ifit is triggered by other risk factors.There havebeen a few reports of a possible association  \nbetween serious head injuries and the later onsetof AD,but otherwise no other risk factors havebeen unequivocally identified for AD.  \n# What To Expect When Someone HasAlzheimer's Disease\n\nThe onset of AD is usually very slow andgradual,rarely occurring before age 65.Overtime,however,it follows a progressively moreserious course.Among the various symptomsthat typically develop,none is unique to AD.Many other conditions—both physical andpsychological—can mimic AD at its variousstages.It is therefore essential for suspiciouschanges to be thoroughly evaluated before theybecome inappropriately or negligently labeledAlzheimer's disease.  \nProblems of memory,particularly recent orshort-term memory,are common early in thecourse of the disease.For example,the individ-ual may,on repeated occasions.forget to turn offthe oven or may not recall which of the morning'smedicines were taken.Mild personality changes,such as less spontaneity or a sense of apathy anda tendency to withdraw from social interac-tions,occur early in the illness.As the diseaseprogresses,problems in abstract thinking or i","cbCairjV75awgLGZ","https://ap.wps.com/l/cbCairjV75awgLGZ","pdf",696644,"English","# Introduction\n# Who Gets Alzheimer's Disease?\n# What To Expect When Someone HasAlzheimer's Disease","[{\"question\":\"Why is Alzheimer’s Disease not considered a normal part of aging?\",\"answer\":\"Alzheimer’s Disease is described as a disease with unknown cause that affects a small but significant percentage of people aged 65 and older, rather than an inevitable outcome of later life.\"},{\"question\":\"Does heredity play a role in developing Alzheimer’s Disease?\",\"answer\":\"A family pattern has been described and a genetic marker on chromosome 21 has been identified for certain families. However, overall knowledge of the genetic aspects is limited, and most individuals’ risk is only slightly higher than the general population.\"},{\"question\":\"What symptoms may appear over time in Alzheimer’s Disease?\",\"answer\":\"The text notes early problems with recent or short-term memory, mild personality changes, and later difficulties with abstract thinking and daily functioning. As the disease progresses, individuals may become disoriented, lose abilities for conversation and self-care, and experience severe complications before death.\"}]","Alzheimer's Disease - Introduction, Who Gets It, and What to Expect | PDF",1789964647]