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Growing evidence links alternative splicing (AS) to tumor initiation and growth, invasion, metastasis, and drug resistance. AS also shapes the tumor microenvironment by regulating factors for angiogenesis, immune signaling, and extracellular matrix remodeling, thereby influencing both disease progression and therapeutic response. Clarifying AS mechanisms in HNSCC may reveal molecular changes and enable new treatment targets, including tailored chemotherapy and immunotherapy strategies aligned to specific AS patterns. This review summarizes AS concepts, types, processes, and technological advances across initiation, progression, treatment, and prognosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/alternative-splicing-landscape-of-head-and-neck-squamous-cell-carcinoma-review-overview/328497/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/alternative-splicing-landscape-of-head-and-neck-squamous-cell-carcinoma-review-overview/328497.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is alternative splicing (AS) considered important in head and neck squamous cell carcinoma (HNSCC)?","Question",{"text":112,"@type":113},"AS is associated with multiple cancer progression processes, including tumor occurrence, invasion, metastasis, and drug resistance. It also contributes to shaping the tumor microenvironment that affects disease development and therapy response.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does AS influence the tumor microenvironment in HNSCC?",{"text":117,"@type":113},"AS affects the expression of factors involved in angiogenesis, immune response, and extracellular matrix remodeling. These changes help form a supportive microenvironment for tumor growth.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the goal of investigating AS mechanisms in HNSCC?",{"text":121,"@type":113},"Understanding how AS contributes to molecular changes in HNSCC and influences the tumor microenvironment may help identify new therapeutic targets. The review also highlights the potential for tailored chemotherapy and immunotherapy strategies based on specific AS patterns.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328497,1790219837,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Alternative Splicing Landscape of Head and Neck Squamous Cell Carcinoma  \nKehan Wu, MD 1 , Qianhui Sun, MD2, Dongxu Liu, MD 1, Jiayi Lu, MD 1, Deyu Wen, MD 1, Xiyan Zang, MD 1, and Li Gao, MD 1  \nTechnology in Cancer Research & Treatment  \nVolume 23: 1-19  \n© The Author(s) 2024  \nArticle reuse guidelines: [sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/15330338241272051](DOI: 10.1177/15330338241272051)[ ](DOI: 10.1177/15330338241272051)[journals.sagepub.com/home/tct](journals.sagepub.com/home/tct)  \nAbstract  \nHead and neck malignancies are a significant global health concern, with head and neck squamous cell carcinoma (HNSCC) being the sixth most common cancer worldwide accounting for > 90% of cases. In recent years, there has been growing recognition of the potential role of alternative splicing (AS) in the etiology of cancer. Increasing evidence suggests that AS is associated with various aspects of cancer progression, including tumor occurrence, invasion, metastasis, and drug resistance. Additionally, AS is involved in shaping the tumor microenvironment, which plays a crucial role in tumor development and response to therapy. AS can influence the expression of factors involved in angiogenesis, immune response, and extracellular matrix remodeling, all of which contribute to the formation of a supportive microenvironment for tumor growth. Exploring the mechanism of AS events in HNSCC could provide insights into the development and progression of this cancer, as well as its interaction with the tumor microenvironment. Understanding how AS contributes to the molecular changes in HNSCC cells and influences the tumor microenvironment could lead to the identification of new therapeutic targets. Targeted chemotherapy and immunotherapy strategies tailored to the specific AS patterns in HNSCC could potentially improve treatment outcomes and reduce side effects. This review explores the concept, types, processes, and technological advancements of AS, focusing on its role in the initiation, progression, treatment, and prognosis of HNSCC.  \nKeywords  \nhead and neck malignancies, alternative splicing, splicing factor, splice variants, treatment targets, drug resistance  \nAbbreviations  \nAKT3, AKT Serine/Threonine Kinase 3; Anilin, actin-binding protein; ANLN, hnRNP, hetero-ribonucleoprotein; AS, alternative splicing; ASO, antisense oligonucleotides; CDK2, Cyclin-dependent kinase 2; CXCR3, C-X-C motif chemokine receptor 3; DOCK5, dedicator of cytokinesis 5; EMT, epithelial-to-mesenchymal transition; ERK, extracellular signal-regulated kinase; ESE, exon splicing enhancers; ESS, exon splicing silencers; hnRNP, heterologous nuclear ribosome proteins; NSCC, head and necksquamous cell carcinoma; HPV, human papillomavirus; IAP, inhibitor of apoptosis; IFN-α 2b, interferon-α 2b; IgV, immunoglobulin variable; ISE, intron splicing enhancers; ISS, intron splicing silencers; LAMA3, Laminin α3; lncRNAs, long non-coding RNAs; LOXL2, Lysyl oxidase-like 2; McL-1, Myeloid cell leukemia-1; ncRNAs, non-coding RNAs; NF-κB, nuclear factor kappa; NK, natural killer; NTC, NineTeen complex; NTR, NTC-related; OPSCC, oropharyngeal squamous cell carcinoma; ORAOV1, Oral Cancer Overexpressed 1; PD-1, programmed death protein 1; Poly A, polyadenylation; PTX, paclitaxel; RAGE, receptor for advanced glycation end products; RNAi, RNA interference; SBOs, Steric-blocking oligonucleotides; snRNA, small nuclear RNA molecules; snRNP, small nuclear ribonucleoproteins; SR, serine/arginine-rich protein; SRPK2, Serine/arginine protein kinase 2; STAT3, Signal transducers and activators of Transcription 3; TACC1, Transforming acidic coiled-coil containing protein1; TCGA, The Cancer Genome Atlas; TNFα, tumor necrosis factor-alpha; USO1, Vesicle transport factor; VEGF-A, Vascular endothelial growth factor A; ZEB1, zinc finger E-box-binding homeobox 1 .  \n1 Department of Oral and Maxillofacial Surgery, The Second Affili","cbCaikMa2hFqurnk","https://ap.wps.com/l/cbCaikMa2hFqurnk","pdf",1852701,"English","# Introduction\n# Abstract\n# Keywords\n# Abbreviations\n# Alternative splicing overview in HNSCC\n## Roles in tumor initiation, progression, and drug resistance\n## Impact on tumor microenvironment and therapy response","[{\"question\":\"Why is alternative splicing (AS) considered important in head and neck squamous cell carcinoma (HNSCC)?\",\"answer\":\"AS is associated with multiple cancer progression processes, including tumor occurrence, invasion, metastasis, and drug resistance. It also contributes to shaping the tumor microenvironment that affects disease development and therapy response.\"},{\"question\":\"How does AS influence the tumor microenvironment in HNSCC?\",\"answer\":\"AS affects the expression of factors involved in angiogenesis, immune response, and extracellular matrix remodeling. These changes help form a supportive microenvironment for tumor growth.\"},{\"question\":\"What is the goal of investigating AS mechanisms in HNSCC?\",\"answer\":\"Understanding how AS contributes to molecular changes in HNSCC and influences the tumor microenvironment may help identify new therapeutic targets. The review also highlights the potential for tailored chemotherapy and immunotherapy strategies based on specific AS patterns.\"}]","Alternative Splicing Landscape of Head and Neck Squamous Cell Carcinoma - Review overview | PDF",1789979984,48]