[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331141-105":59,"doc-detail-331141-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","alternative-magnetic-field-exposure-suppresses-tumor-growth-via-metabolic-reprogramming","Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming","","Alternating magnetic field (AMF) exposure is shown to exert a direct anti-cancer effect by enhancing oxidative phosphorylation (OXPHOS) and triggering metabolic reprogramming. Human glioblastoma multiforme (GBM) cell proliferation is inhibited after AMF exposure at a narrow frequency range, including around 227 kHz, while normal human astrocytes remain unaffected. In orthotopic mouse models, daily AMF for 30 minutes across 21 days suppresses tumor growth and extends overall survival. The response involves increased reactive oxygen species (ROS) and MnSOD upregulation, with reduced efficacy upon blocking mitochondrial complex IV or scavenging ROS, accompanied by decreased ECAR and increased OCR.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/alternative-magnetic-field-exposure-suppresses-tumor-growth-via-metabolic-reprogramming/331141/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/alternative-magnetic-field-exposure-suppresses-tumor-growth-via-metabolic-reprogramming/331141.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does AMF inhibit glioblastoma tumor growth according to the study?","Question",{"text":112,"@type":113},"AMF enhances oxidative phosphorylation (OXPHOS), inducing metabolic reprogramming in GBM cells. This is accompanied by increased reactive oxygen species (ROS) production and elevated MnSOD expression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cells respond to AMF exposure, and what happens to normal cells?",{"text":117,"@type":113},"GBM cell proliferation is inhibited when exposed to AMF within a specific narrow frequency range (including around 227 kHz). The exposure does not affect normal human astrocytes.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence links the anti-cancer effect to ROS and mitochondria?",{"text":121,"@type":113},"The anti-cancer efficacy is diminished by a mitochondrial complex IV inhibitor or a ROS scavenger. Metabolic readouts also shift toward reduced extracellular acidification rate (ECAR) and increased oxygen consumption rate (OCR).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331141,1790093916,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","DOI: 10. 1111/cas.16243  \nOR I G I NAL ART I C L E  \nAlternative magnetic field exposure suppresses tumor growth via metabolic reprogramming  \nTaisuke Akimoto1 | Md Rafikul Islam2 | Akane Nagasako3 | Kazuhito Kishi4 |  \nRina Nakakaji3 | Makoto Ohtake1 | Hisashi Hasumi5  | Takashi Yamaguchi4 | Shigeki Yamada6 | Tetsuya Yamamoto1 | Yoshihiro Ishikawa3 | Masanari Umemura3   \n1Department of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan 2Department of Biochemistry and Molecular Biology, Winthrop P.  \nRockefeller Cancer Institute, University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas, USA 3Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan  \n4Ricoh Company, Ltd. , Ohta-ku, Tokyo, Japan  \n5Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan 6Department of Materials System Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan  \nCorrespondence  \nMasanari Umemura, Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.  \nEmail: [umemurma@yokohama-cu.ac.jp](umemurma@yokohama-cu.ac.jp)  \nFunding information  \nJapan Science and Technology Agency, Grant/Award Number: JPMJFR205A; Japan Agency for Medical Research and Development, Grant/Award Number:  \n19191258 and 23810577; Japan Society for the Promotion of Science, Grant/ Award Number: 22K06928; Ricoh Co. , Ltd.  \nAbstract  \nApplication of physical forces, ranging from ultrasound to electric fields, is recommended in various clinical practice guidelines, including those for treating cancersand bone fractures. However, the mechanistic details of such treatments are often inadequately understood, primarily due to the absence of comprehensive study models. In this study, we demonstrate that an alternating magnetic field (AMF) inherently possesses a direct anti-cancer effect by enhancing oxidative phosphorylation (OXPHOS) and thereby inducing metabolic reprogramming. We observed that the proliferation of human glioblastoma multiforme (GBM) cells (U87 and LN229) was inhibited upon exposure to AMF within a specific narrow frequency range, including around 227 kHz. In contrast, this exposure did not affect normal human astrocytes (NHA) . Additionally, in mouse models implanted with human GBM cells in the brain, daily exposure to AMF for 30 min over 21 days significantly suppressed tumor growth and prolonged overall survival. This effect was associated with heightened reactive oxygen species (ROS) production and increased manganese superoxide dismutase (MnSOD) expression. The anti-cancer efficacy of AMF was diminished by either a mitochondrial complex IV inhibitor or a ROS scavenger. Along with these observations, there was a decrease in the extracellular acidification rate (ECAR) and an increase in the oxygen consumption rate (OCR) . This suggests that AMF-induced metabolic reprogramming occurs in GBM cells but not in normal cells. Our results suggest that AMF exposure may offer a straightforward strategy to inhibit cancer cell growth by leveraging oxidative stress through metabolic reprogramming.  \nK E Y WO R D S  \nalternating magnetic field (AMF), glioblastoma multiforme (GBM), metabolic reprogramming, mitochondria, oxidative phosphorylation (OXPHOS), reactive oxygen species (ROS)  \nTaisuke Akimoto and Md Rafikul Islam authors contributed equally to this study.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.  \n© 2024 The Author(s) . Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.  \n1 | INTRODUCTION  \nGlioblastoma multiforme (GBM) is the","cbCaijjX3pT46wok","https://ap.wps.com/l/cbCaijjX3pT46wok","pdf",18067801,15,"English","# Abstract\n# Introduction","[{\"question\":\"How does AMF inhibit glioblastoma tumor growth according to the study?\",\"answer\":\"AMF enhances oxidative phosphorylation (OXPHOS), inducing metabolic reprogramming in GBM cells. This is accompanied by increased reactive oxygen species (ROS) production and elevated MnSOD expression.\"},{\"question\":\"Which cells respond to AMF exposure, and what happens to normal cells?\",\"answer\":\"GBM cell proliferation is inhibited when exposed to AMF within a specific narrow frequency range (including around 227 kHz). The exposure does not affect normal human astrocytes.\"},{\"question\":\"What evidence links the anti-cancer effect to ROS and mitochondria?\",\"answer\":\"The anti-cancer efficacy is diminished by a mitochondrial complex IV inhibitor or a ROS scavenger. Metabolic readouts also shift toward reduced extracellular acidification rate (ECAR) and increased oxygen consumption rate (OCR).\"}]","Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming | PDF",1789991936,38]