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Prior work emphasized static interoception measures (e.g., heart-evoked potential, HEP) that do not represent the dynamic character captured by intrinsic neural timescales. We hypothesised longer intrinsic neural timescales of interoception in bvFTD. Methods: 112 participants completed a cardiac-interoception/exteroception task with simultaneous EEG/ECG; intrinsic neural timescales were derived using the autocorrelation window (ACW).",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/altered-spatiotemporal-brain-dynamics-of-interoception-in-behavioural-variant-frontotemporal-dementia/456222/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/altered-spatiotemporal-brain-dynamics-of-interoception-in-behavioural-variant-frontotemporal-dementia/456222.png","ImageObject",300,407,{"name":92,"@type":93},"Jasmine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main background rationale for studying interoception in bvFTD?","Question",{"text":112,"@type":113},"The document states that bvFTD involves dysfunctional allostatic-interoception, reflected in altered processing of bodily signals. It highlights that earlier studies used static interoception measures and may miss dynamic aspects.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were intrinsic neural timescales of interoception measured?",{"text":117,"@type":113},"Intrinsic neural timescales were measured via the autocorrelation window (ACW) of broadband EEG signals from each heartbeat and a time-lagged version of itself.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings in bvFTD and Alzheimer’s disease patients?",{"text":121,"@type":113},"In bvFTD, longer interoceptive-ACWs than controls were observed in bilateral fronto-temporal and parietal regions, and linked to worse sociocognitive performance in bvFTD only. In AD, longer interoceptive-ACWs appeared in central and occipitoparietal regions, with no exteroception differences.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},456222,1791477936,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52},2336478487870,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","DOI: 10. 1002/alz70856_104944  \nBIOMARKERS  \nPOSTER PRESENTATION  \nNEUROIMAGING  \nAltered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia  \nJessica L Hazelton1, 2, 3  Gabriel Della Bella4, 5  Pablo Barttfeld4, 6  Martin Dottori 1  \nRaul Gonzalez-Gomez6  Joaquín Migeot6, 7  Sebastian Moguilner6   \nAgustina Legaz 1, 6  Hernan Hernandez6  Pavel Prado8  Jhosmary Cuadros6, 9, 10  \nMarcelo Adrian Maito6  Matias Fraile-Vazquez 11  María Luz González Gadea6, 12 Yasir Çatal 13  Bruce L. Miller 14, 15  Olivier Piguet2, 16  Georg Northoff 13, 17, 18 Agustin Ibanez 1, 6, 7  \n1 Cognitive Neuroscience Center (CNC), Universidad de San Andrés, Buenos Aires, Buenos Aires, Argentina  \n2The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia  \n3 Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Santiago, Chile  \n4 Instituto de Investigaciones Psicológicas (IIPsi, CONICET-UNC), Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Córdoba, Argentina  \n5 Facultad de Matemática Astronomíay Física (FaMAF), Universidad Nacional de Córdoba, Córdoba, Córdoba, Argentina  \n6 Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibáñez, Santiago, Región Metropolitana de Santiago, Chile  \n7 Global Brain Health Institute (GBHI), University of California San Francisco (UCSF);& Trinity College Dublin, Dublin, Leinster, Ireland  \n8 Escuela de Fonoaudiología, Facultad de Odontologíay Ciencias de la Rehabilitación, Universidad San Sebastián, Chile, Santiago, Región Metropolitana de Santiago, Chile  \n9Advanced Center for Electrical and Electronic Engineering (AC3E), Universidad Técnica Federico Santa María, Valparaíso, Yaracuy, Venezuela (Bolivarian Republic of)  \nAbstract  \nBackground: Dysfunctional allostatic-interoception, altered processing of bodily signals in response to environmental demands, occurs in behavioural-variant frontotemporal dementia (bvFTD) patients. Previous research, however, has focused on static measures of interoception (e.g., heart-evoked potential, HEP). These measures do not capture the dynamic nature of interoception, unlike intrinsic neural timescales. Intrinsic neural timescales refers to the temporal durations over which information is processed within the spatiotemporal hierarchy of the brain, with shorter timescales representing more rapid processing. We hypothesised that longer intrinsic neural timescales of interoception would occur in bvFTD patients, evidencing dysfunctional allostatic-interoception.  \nMethod: One-hundred and twelve participants (31 bvFTD patients, 35 Alzheimer’s disease patients, AD and 46 healthy controls) completed a well-validated task measuring cardiac-interoception and exteroception. Simultaneous EEG and ECG were recorded. Intrinsic neural timescales were measured via the autocorrelation window (ACW) of broadband EEG signals from each heartbeat and a time-lagged version of itself. Spatiotemporal clustering analyses identified clusters with significant betweengroup differences in each condition. HEP modulation analyses were also conducted and covaried for to investigate potential relationships between HEP and ACW. Voxel-based morphometry was used to target the allostatic-interoceptive network. Neuropsychological tests of cognition and social cognition were assessed.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e104944.  \n[https://doi.org/10.1002/alz70856_104944](https://doi.org/10.1002/alz70856_104944)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of4  \nBIOMARKERS  \n10 Universidad Nacional Experimental del Táchira, San Cristóbal, Táchi","cbCaicjMSbIaeZlB","https://ap.wps.com/l/cbCaicjMSbIaeZlB","pdf",1025118,"English","# Abstract\n## Background\n## Method\n## Results\n## Conclusion","[{\"question\":\"What is the main background rationale for studying interoception in bvFTD?\",\"answer\":\"The document states that bvFTD involves dysfunctional allostatic-interoception, reflected in altered processing of bodily signals. It highlights that earlier studies used static interoception measures and may miss dynamic aspects.\"},{\"question\":\"How were intrinsic neural timescales of interoception measured?\",\"answer\":\"Intrinsic neural timescales were measured via the autocorrelation window (ACW) of broadband EEG signals from each heartbeat and a time-lagged version of itself.\"},{\"question\":\"What were the key findings in bvFTD and Alzheimer’s disease patients?\",\"answer\":\"In bvFTD, longer interoceptive-ACWs than controls were observed in bilateral fronto-temporal and parietal regions, and linked to worse sociocognitive performance in bvFTD only. In AD, longer interoceptive-ACWs appeared in central and occipitoparietal regions, with no exteroception differences.\"}]","Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia | PDF",1790745369]