[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-355169-105":3,"doc-detail-355169-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","alterations-in-lipid-metabolism-and-blood-profile-in-gynecological-cancers-potential-strategies-in-diagnosis-and-treatment","Alterations in lipid metabolism and blood profile in gynecological cancers - potential strategies in diagnosis and treatment","","Gynecological cancers, particularly endometrial, cervical, and ovarian cancers, cause substantial disease burden due to rising incidence and limited outcomes in advanced stages. This review explains how reprogramming of lipid metabolism contributes to cancer development and progression, emphasizing changes in serum/plasma lipid profiles and membrane composition, dysregulated fatty-acid uptake and β-oxidation, and increased lipogenic enzyme activity in tumor tissues and cell lines. It further evaluates lipid alterations as candidate diagnostic and therapeutic strategies while noting the need for additional studies to clarify links to clinical practice.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/alterations-in-lipid-metabolism-and-blood-profile-in-gynecological-cancers-potential-strategies-in-diagnosis-and-treatment/355169/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/alterations-in-lipid-metabolism-and-blood-profile-in-gynecological-cancers-potential-strategies-in-diagnosis-and-treatment/355169.png","ImageObject",300,407,{"name":42,"@type":43},"Miles","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Which gynecological cancers are emphasized in this review?","Question",{"text":63,"@type":64},"The review focuses on endometrial, cervical, and ovarian cancers as major forms of gynecological cancers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What lipid metabolism changes are discussed for cancer development and progression?",{"text":68,"@type":64},"It highlights altered serum/plasma lipid profiles and membrane lipid composition, dysregulated fatty-acid uptake and β-oxidation, and upregulation of lipogenic enzymes in tumors and cell lines.",{"name":70,"@type":61,"acceptedAnswer":71},"How are lipid alterations proposed to support diagnosis and treatment?",{"text":72,"@type":64},"The review describes lipid alterations as potential noninvasive biomarkers and as possible diagnostic and therapeutic strategies, while stressing that further studies are needed for clear conclusions.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},355169,1790207648,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0",7,"TYPE Review  \nPUBLISHED 16 February 2026  \nDOI 10.3389/fphys.2026.1741759  \nOPEN ACCESS  \nEDITED BY  \nAnna Maria Giudetti, University of Salento, Italy  \nREVIEWED BY  \nDaniele Vergara, University of Salento, Italy Vivek S. Peche,  \nSt. Jude Children’s Research Hospital, United States  \n*CORRESPONDENCE  \nTomasz Sledzinski,  \n [tsledz@gumed.edu.pl](tsledz@gumed.edu.pl)  \nRECEIVED 07 November 2025  \nREVISED 29 December 2025  \nACCEPTED 02 January 2026  \nPUBLISHED 16 February 2026  \nCITATION  \nRazghonova Y, Abacjew-Chmylko A, Czapiewska M, Wydra D, Swierczynski J, Mika A and Sledzinski T (2026) Alterations in lipid metabolism and blood profile in gynecological cancers – potential strategies in diagnosis and treatment.  \nFront. Physiol. 17:1741759.  \ndoi: 10.3389/fphys.2026.1741759  \nCOPYRIGHT  \n© 2026 Razghonova, Abacjew-Chmylko, Czapiewska, Wydra, Swierczynski, Mika and Sledzinski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nAlterations in lipid metabolism and blood profile in gynecological cancers – potential strategies in diagnosis and treatment  \nYelyzaveta Razghonova 1, Anna Abacjew-Chmylko 2, Monika Czapiewska 1, Dariusz Wydra 2, Julian Swierczynski 3, Adriana Mika 1,4 and Tomasz Sledzinski 1*  \n1 Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland, 2 Department of Gynecology, Obstetrics and Neonatology, Medical University of Gdansk, Gdansk, Poland, 3 Institue of Nursing and Medical Rescue, State University of Applied Sciences in Koszalin, Koszalin, Poland, 4 Department of Environmental Analytics, Faculty of Chemistry, University of Gdansk, Gdansk, Poland  \nGynecological cancers (GCs), especially endometrial, cervical and ovarian cancers, represent a major health burden due to their increasing incidence and poor treatment outcomes, particularly in advanced stages. Numerous papers suggest that reprogramming of lipid metabolism plays an important role in the development and progression of GCs. In this review, we discuss the alterationsin lipid metabolism, focusing on a) serum/plasma lipid profiles and changes in membrane lipid composition in GCs patients, b) dysregulation of fatty acid uptake and β-oxidation by GCs cells, and c) upregulation of lipogenic enzymes in cancer tissue of GCs patients and GCs cells lines. It appears that lipid alterationsin the development and progression of GCs are very complex and cancer type specific. This is due to the complexity of a) the structure and properties of lipids, b) the variability between different human cancer types, and c) the need for a comprehensive set of clinical data. Moreover, the review highlights alterations of lipid metabolism as potential diagnostic and therapeutic strategies in the treatment of GC patients. Further studies are still needed to draw clear conclusions about the relationship between abnormalities in lipid metabolism and development of GCs and to bridge basic research and practice.  \nKEYWORDS  \ncervical cancer, endometrial cancer, fatty acids, lipogenic enzymes, ovarian cancer  \n1 Introduction  \nIn 2022, more than 1.5 million women worldwide were diagnosed with gynecological cancers (GCs) (Worldwide cancer data, 2024; Sung et al., 2021), and GCs accounted for 15.2% of all cancers diagnosed in women in that year (Worldwide cancer data, 2024) . The most common GCs include malignancies of the endometrium, cervix and ovaries (Worldwide cancer data, 2024) and in this review we will focus primarily on the lipid metabolism of these cancers (Worldwide cancer data, 2024) . Lipids not only constitute structural el","cbCaipvCOvqQpk4o","https://ap.wps.com/l/cbCaipvCOvqQpk4o","pdf",1808930,25,"English","# Introduction\n# Lipid metabolism axes in cancer\n# Lipid alterations as biomarkers\n# Analytical approaches and study limitations\n# Therapeutic strategies targeting metabolism","[{\"question\":\"Which gynecological cancers are emphasized in this review?\",\"answer\":\"The review focuses on endometrial, cervical, and ovarian cancers as major forms of gynecological cancers.\"},{\"question\":\"What lipid metabolism changes are discussed for cancer development and progression?\",\"answer\":\"It highlights altered serum/plasma lipid profiles and membrane lipid composition, dysregulated fatty-acid uptake and β-oxidation, and upregulation of lipogenic enzymes in tumors and cell lines.\"},{\"question\":\"How are lipid alterations proposed to support diagnosis and treatment?\",\"answer\":\"The review describes lipid alterations as potential noninvasive biomarkers and as possible diagnostic and therapeutic strategies, while stressing that further studies are needed for clear conclusions.\"}]","Alterations in lipid metabolism and blood profile in gynecological cancers - potential strategies in diagnosis and treatment | PDF",1790116470,63,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,126,131,136,139,143],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":124,"slug":125},40,"healthcare",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":129,"slug":130},8,"Research & Report",30,"research-report",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":133,"show_sort_weight":134,"slug":135},9,"Religion & Spirituality",20,"religion-spirituality",{"id":134,"doc_module":4,"doc_module_name":25,"category_name":137,"show_sort_weight":134,"slug":138},"World Cup","world-cup",{"id":140,"doc_module":4,"doc_module_name":25,"category_name":141,"show_sort_weight":140,"slug":142},10,"Lifestyle","lifestyle",{"id":144,"doc_module":4,"doc_module_name":25,"category_name":145,"show_sort_weight":114,"slug":146},19,"General","general"]