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Journal 27 (1): 72-78 January 2023 |\n| --- | --- |\n\nAlteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer  \nMehdi Alikhani1 , Maryam Esmaeili 1 , Mohammad Tashakoripour2 , Mohammad Ali Mohagheghi3 , Mahmoud Eshagh Hosseini2 , Eliette Touati4 , Massoud Vosough5 , Marjan Mohammadi 1*  \n1HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran; 2Gastroenterology Department, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran; 3Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran; 4 Institut Pasteur, Unit of Helicobacter Pathogenesis, CNRS UMR2001, 25-28 Rue du Dr Roux, 75724 Paris Cedex 15, France; 5Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran  \nOPEN ACCESS  \nReceived: 18 October 2022  \nAccepted: 19 December 2022  \nPublished online: 21 December 2022  \nCitation:  \nAlikhani M, Esmaeili M, Tashakoripour M, Mohagheghi MA, Hosseini ME, Touati E, Vosough M, Mohammadi M. Alteration in Serum Levels of Tumor Necrosis Factor  \nABSTRACT  \nBackground: The role of inflammatory cytokines, such as TNF-α and IL-8, in gastric carcinogenesis has been investigated, but their impact remains to be further elucidated.  \nMethods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA.  \nResults: Moderate levels of TNF-α were detected in the NM group (19 .9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35 .7 ± 28.0 pg/ml) and drastically declined in GC patients (1 .8 ± 5.9 pg/ml) . The serum levels of IL-8, however, were not statistically different amongst these three groups.  \nConclusion: TNF-α serum concentration seemed to undergo up- and downregulation, when moving from NM to CG and from CG to GC,  \nAlpha is associated with Histopathologic Progression of Gastric Cancer. Iranian biomedical journal 2023; 27(1): 72-78.  \nrespectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation.  \nDOI: 10.52547/ibj.3847  \nKeywords: Inflammation, Interleukin-8, cytokines, Tumor necrosis factor-alpha  \nCorresponding Author: Marjan Mohammadi  \nHPGC Research Group, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;  \n[E-mail:](E-mail: marjan.mohammadi@pasteur.ac.ir)[ marjan.mohammadi@pasteur.ac.ir](E-mail: marjan.mohammadi@pasteur.ac.ir); [marjan.mohammadi2010@gmail.com](marjan.mohammadi2010@gmail.com)  \nINTRODUCTION  \nGastric cancer was recognized as the fourth  \nworldwide cause of cancer death in 2020.  \nAmong the different types of GC, the intestinal type is the most prevalent one[1] . This GC subtype is highly affected by environmental and genetic factors and is preceded by a cascade of precancerous lesions, as previously described by Correa and Piazuelo[2] . According to Correa’s model, primarily, the normal mucosa of the stomach becomes inflamed, otherwise known as gastritis. Gastric inflammation is initiated by  \nseveral factors, including H. pylori infection, high-salt diet, nitrate intake, etc. Gastritis may then develop into atrophic gastritis, intestinal metaplasia, dysplasia, and ultimately gastric cancer[2] .  \nTNF-α is a critical cytokine, which is mainly produced by macrophages and is involved in many biological processes, such as acute and chronic inflammation. In the process of carcinogenesis, it has a dual role by which it causes tumor cell death and apoptosis, on the one hand, and potentiatestumorigenesis and progression, on the other hand[3] . IL- 8 is another pro-inflammatory chemokine with varying  \nList of Abbre","cbCaipAddo8DLKZM","https://ap.wps.com/l/cbCaipAddo8DLKZM","pdf",1005242,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Materials and Methods","[{\"question\":\"What was measured in this study and in which patient groups?\",\"answer\":\"Serum TNF-α and IL-8 concentrations and H. pylori serostatus were measured in dyspeptic patients with normal mucosa (NM), chronic gastritis (CG), and gastric cancer (GC) using ELISA.\"},{\"question\":\"How did TNF-α levels change across NM, CG, and GC?\",\"answer\":\"TNF-α was moderate in the NM group, nearly doubled in CG, and drastically declined in GC patients, indicating up- and downregulation across disease stages.\"},{\"question\":\"Did IL-8 show differences among the three groups?\",\"answer\":\"No statistically significant differences in serum IL-8 levels were found among the NM, CG, and GC groups.\"}]","Alteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer | PDF",1790567470,18]