[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-330346-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-330346-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","allicin-and-cancer-hallmarks-review","Allicin and Cancer Hallmarks - Review","","Natural products, particularly medicinal plants, are crucial for combating cancer and for discovering and developing new therapeutic agents based on their biologically active compounds. Such agents provide a promising route to effective anticancer medications due to low toxicity, diverse chemical structures, and the ability to target multiple cancers. Allicin, a sulfur bioactive from garlic (Allium sativum L.), may act on key cancer hallmarks that drive cancer development and spread. This review compiles allicin’s anticancer roles across these hallmarks to support fundamental and clinical studies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/allicin-and-cancer-hallmarks-review/330346/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/allicin-and-cancer-hallmarks-review/330346.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is allicin and where does it come from?","Question",{"text":63,"@type":64},"Allicin is a bioactive sulfur compound found in garlic (Allium sativum L.) and exists in plant sections in a precursor state.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which cancer hallmarks does this review focus on for allicin’s anticancer effects?",{"text":68,"@type":64},"The review considers eight hallmark categories, including sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, induction of angiogenesis, invasion and metastasis, reprogramming of energy metabolism, and evasion of immune destruction.",{"name":70,"@type":61,"acceptedAnswer":71},"How might allicin exert anticancer activity according to the review?",{"text":72,"@type":64},"The review reports that allicin can inhibit cancer cell proliferation, induce apoptosis, and enhance reactive oxygen species accumulation, aligning with targeted hallmark pathways.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330346,1790006912,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":118,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":104,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","molecules   \nReview  \nAllicin and Cancer Hallmarks  \nWamidh H. Talib 1, *, Media Mohammed Baban 2, Aya O. Azzam 2, Jenan J. Issa 2, Alaa Y. Ali 2, Alia Kh. AlSuwais 2, Sana Allala 2 and Lina T. AL Kury 3, *  \n1 Faculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, Jordan  \n2 Department of Clinical Pharmacy and Therapeutics, Applied Science University, Amman 11931, Jordan; [mediababan22@gmail.com](mediababan22@gmail.com) (M.M.B.); [ay_azzam@asu.edu.jo](ay_azzam@asu.edu.jo) (A.O.A.); [jenanjamal@hotmail.com](jenanjamal@hotmail.com) (J.J.I.); [alaa.yaserali@gmail.com](alaa.yaserali@gmail.com) (A.Y.A.); [aliakh.alsuwais@outlook.com](aliakh.alsuwais@outlook.com) (A.K.A.); [sanaallala8@gmail.com](sanaallala8@gmail.com) (S.A.)  \n3 Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi 144534, United Arab Emirates  \n* [Correspondence: w_talib@asu.edu.jo](Correspondence: w_talib@asu.edu.jo) (W.H.T.); [lina.alkury@zu.ac.ae](lina.alkury@zu.ac.ae) (L.T.A.K.)  \nAbstract: Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxicity, diverse chemical structures, and ability to target various cancers. Allicin is oneof the main ingredients in garlic (Allium sativum L.) . It is a bioactive sulfur compound maintained in various plant sections in a precursor state. Numerous studies have documented the positive health benefits of this natural compound on many chronic conditions, including gastric, hepatic, breast, lung, cervical, prostate, and colon cancer. Moreover, allicin may target several cancer hallmarks or fundamental biological traits and functions that influence cancer development and spread. Cancer hallmarks include sustained proliferation, evasion of growth suppressors, metastasis, replicative immortality, angiogenesis, resistance to cell death, altered cellular energetics, and immune evasion. The findings of this review should provide researchers and medical professionals with a solid basis to support fundamental and clinical investigations of allicin as a prospective anticancer drug. This review outlines the anticancer role of allicin in each hallmark of cancer.  \nCitation: Talib, W.H.; Baban, M.M.; Azzam, A.O.; Issa, J.J.; Ali, A.Y.; AlSuwais, A.K.; Allala, S.; AL Kury, L.T. Allicin and Cancer Hallmarks. Molecules 2024, 29, 1320. [https://](https://)[ ](https://)[doi.org/10.3390/molecules29061320](doi.org/10.3390/molecules29061320)  \nAcademic Editors: Kuniyoshi Shimizu andYhiya Amen  \nReceived: 15 February 2024  \nRevised: 11 March 2024  \nAccepted: 13 March 2024  \nPublished: 15 March 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nKeywords: allicin; cancer hallmarks; anticancer; angiogenesis; metastasis; immune evasion  \n1. Introduction  \nCancer, the second-leading cause of death worldwide, is one of the biggest public health problems, resulting in the annual mortality of 10 million people [1] . Because of the detrimental effects that cancer and its treatment have on financial resources and the healthcare system, greater focus must be paid to creating novel preventative and therapeutic approaches that are both affordable and efficacious [2] . Natural products are a viable source for the development of new, effective anticancer medications because of their low toxicity, diversity of chemical structures, and capacity to target many cancers [3] . One of these compounds is allicin which is a potent bioactive in g","cbCaihn84eiMkXZz","https://ap.wps.com/l/cbCaihn84eiMkXZz","pdf",1215541,"English","# Introduction\n# Allicin\n## Allicin Chemical Structure and Formation","[{\"question\":\"What is allicin and where does it come from?\",\"answer\":\"Allicin is a bioactive sulfur compound found in garlic (Allium sativum L.) and exists in plant sections in a precursor state.\"},{\"question\":\"Which cancer hallmarks does this review focus on for allicin’s anticancer effects?\",\"answer\":\"The review considers eight hallmark categories, including sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, induction of angiogenesis, invasion and metastasis, reprogramming of energy metabolism, and evasion of immune destruction.\"},{\"question\":\"How might allicin exert anticancer activity according to the review?\",\"answer\":\"The review reports that allicin can inhibit cancer cell proliferation, induce apoptosis, and enhance reactive oxygen species accumulation, aligning with targeted hallmark pathways.\"}]","Allicin and Cancer Hallmarks - Review | PDF",1789988366]